IARA MORENO LINHARES
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Influence of recurrent vulvovaginal candidiasis on quality of life issues(2019) I, Eiko Fukazawa; WITKIN, Steven S.; ROBIAL, Renata; VINAGRE, Joao G.; BARACAT, Edmund C.; LINHARES, Iara M.Purpose More than 370 million women will experience recurrent vulvovaginal candidiasis (RVVC) during their lifetime. However, RVVC is often trivialized as clinically insignificant and not worthy of research funding. We evaluated the influence of RVVC on the quality of life in affected women. Methods The validated World Health Organization Quality of Life Abbreviated Assessment (WHOQOL-Bref) questionnaire was administered to 100 women with RVVC and to 101 epidemiologically matched women with no history of vulvovaginal candidiasis. RVVC was defined as at least four episodes of clinical and culture-positive vaginal candidiasis within a 1 year period. Data were analyzed by Chi square, Student t test and analysis of variance. Internal consistency of responses to questions was evaluated by Cronbach alpha. Results The Cronbach alpha coefficient was > 0.80 for responses to generalized questions and > 0.65 for answers to more specific questions, indicating substantial internal consistency. Perception of quality of life and satisfaction with their health was greatly reduced in the RVVC group (p < 0.001). Diminished responses to physical and psychological well-being were also reported by women with RVVC (p < 0.001). Various aspects of social relations including sexual activity were similarly reduced (p < 0.001) as were satisfaction with issues such as home environment, financial resources and employment (p < 0.001). Conclusion RVVC affects multiple aspects of a woman's well-being. Women with this condition deserve serious attention from clinicians and research into susceptibility, prevention and treatment of this infection deserves much greater emphasis.
- Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman(2019) VINAGRE, Joao G.; WITKIN, Steven S.; RIBEIRO, Sergio C.; ROBIAL, Renata; I, Eiko Fukazawa; ORTOLANI, Carla C.; BARACAT, Edmund C.; LINHARES, Iara M.Purpose Factors influencing fallopian tube occlusion in women with a lower genital tract infection remain incompletely elucidated. We evaluated whether a polymorphism in the mannose-binding lectin (MBL) gene at codon 54 influences the occurrence of fallopian tube blockage in relation to exposure to Chlamydia trachomatis. Methods In a case-control study at The Hospital das Clinicas, University of Sao Paulo, Brazil, 75 women with hysterosalpingography-documented tubal occlusion and 75 women with patent fallopian tubes were analyzed for detection of single-nucleotide polymorphism in codon 54 of the MBL gene and for IgG anti-C. trachomatis antibodies in their sera. Both groups were matched for age, race, and sexual variables. Results Prior exposure to C. trachomatis, as evidenced by the presence of IgG antibodies, was comparable in both groups. Detection of the polymorphic MBL allele was more prevalent in women with blocked tubes (p < 0.01), regardless of whether or not there was evidence of prior chlamydial exposure. Conclusion The level of MBL-related innate immunity influences the consequences of infection by C. trachomatis or other microbes.
conferenceObject Mannose-Binding Lectin Gene Polymorphism and Chlamydia Trachomatis Antibodies in Brazilian Women with Tubal Occlusion.(2019) VINAGRE, Joao G.; WITKIN, Steven S.; FUKAZAWA, Eiko I.; ROBIAL, Renata; BARACAT, Edmund C.; LINHARES, Iara M.conferenceObject Influence of Recurrent Vulvovaginal Candidiasis on Quality of Life.(2019) FUKAZAWA, Eiko I.; WITKIN, Steven S. Steven Sol; ROBIAL, Renata; VINAGRE, Joao G.; BARACAT, Edmund C.; LINHARES, Iara M.