CARLOS AUGUSTO GONCALVES PASQUALUCCI
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
ATCIENT-50, SVOC
LIM/22 - Laboratório de Patolologia Cardiovascular, Hospital das Clínicas, Faculdade de Medicina - Líder
ATCIENT-50, SVOC
LIM/22 - Laboratório de Patolologia Cardiovascular, Hospital das Clínicas, Faculdade de Medicina - Líder
28 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 28
conferenceObject Inflammatory factors (cytokines and cortisol) across different brain regions in bipolar disorder and their associations with neuropsychiatric symptoms: A post-mortem study(2020) NASCIMENTO, Camila; NUNES, Paula V.; SUEMOTO, Claudia K.; RODRIGUEZ, Roberta D.; LEITE, Renata E. P.; GRINBERG, Lea T.; PASQUALUCCI, Carlos A.; NITRINI, Ricardo; JACOB-FILHO, Wilson; BRENTANI, Helena P.; LAFER, BenyconferenceObject Brain transcriptome analysis of Japanese population living in Brazil(2019) MARIE, Suely Kazue Nagahashi; LERARIO, Antonio Marcondes; SHINJO, Sueli Mieko Oba; NASCIMENTO, Camila; LEITE, Renata; SUEMOTO, Claudia; PASQUALUCCI, Carlos Augusto; MURAYAMA, ShigeoconferenceObject THE DOWREGULATION EXPRESSION OF PROLINE OXIDASE GENE IMBALANCE GLUTAMATE IN BRAINS OF THE SUBJECTS WITH OBSESSIVE COMPULSIVE DISORDER A POST MORTEM STUDY(2017) OLIVEIRA, Katia de; LISBOA, Bianca Cristina Garcia; CARREIRA, Luzia Lima; GOUVEIA, Gisele Rodrigues; MORETTO, Ariane Cristine; NEVES, Ricardo de Caires; PASQUA-LUCCI, Carlos Augusto; GRINBERG, Lea Tenenholz; JACOB-FILHO, Wilson; LAFER, Beny; MIGUEL, Euripedes Constantino; SHAVITT, Roseli Gedanke; HOEXTER, Marcelo Queiroz; PEREIRA, Carlos Alberto de Bragranca; BRENTANI, Helena- Could the differences in the biochemistry of prostate carcinoma compared to benign prostate tissue biopsy fragments be evaluated through Raman spectroscopy?(2013) SILVEIRA JR., Landulfo; LEITE, Katia Ramos M.; SROUGI, Miguel; SILVEIRA, Fabricio L.; PACHECO, Marcos Tadeu T.; ZANGARO, Renato A.; PASQUALUCCI, Carlos A.It has been proposed a spectral model to evaluate the biochemical differences between prostate carcinoma and benign fragments using dispersive Raman spectroscopy. We have examined 51 prostate fragments from surgically removed PrCa; each fragment was snap-frozen and stored (-80 degrees C) prior spectral analysis. Raman spectrum was measured using a Raman spectrometer (830 nm excitation) coupled to a fiber-optic probe. Integration time and laser power were set to 50 s and 300 mW, respectively. It has been collected triplicate spectra from each fragment (total 153 spectra). Some samples exhibited a strong fluorescence, which was removed by a 7th order polynomial fitting. It has been developed a spectral model based on the least-squares fitting of the spectra of pure biochemicals (actin, collagen, elastin, carotene, glycogen, phosphatidylcholine, hemoglobin, and water) with the spectra of tissues, where the fitting parameters are the relative contribution of the compounds to the tissue spectrum. The spectra (600-1800 cm(-1) range) are dominated by bands of proteins; it has been found a small difference in the mean spectra of PrCa compared to the benign tissue, mainly in the 1000-1400 cm(-1) region, indicating similar biochemical constitution. The spectral fitting model revealed that elastin and phosphatidylcholine were increased in PrCa, whereas blood and water were reduced in malignant lesions (p < 0.05). A discrimination of PrCa from benign tissue using Mahalanobis distance applied to the contribution of elastin, hemoglobin and phosphatidylcholine resulted in sensitivity of 72% and specificity of 70%.
conferenceObject Polarized Macrophages in the Perivascular Adipose Tissue Were Correlated With Atherosclerotic Plaque Components in Coronary Arteries: An Autopsy Study(2019) FARIAS-ITAO, Daniela S.; PASQUALUCCI, Carlos A.; ANDRADE, Renato A.; SILVA, Luiz Fernando F.; CAMPO, Alexandre B.; SUEMOTO, Claudia K.conferenceObject High prevalence of TDP-43 in Asians older adults: a clinicopathological study on a population-based sample(2014) NASCIMENTO, C.; RODRIGUEZ, R. D.; LEITE, R. P.; SUEMOTO, C. K.; ZATZ, M.; PASQUALUCCI, C. A.; FILHO, W. J.; GRINBERG, L. T.conferenceObject D-serine levels in Alzheimer's disease: implications for novel biomarker development(2015) LOURENCO, M.; MADEIRA, C.; VARGAS-LOPES, C.; SUEMOTO, C.; BRANDAO, C. O.; REIS, T.; LEITE, R.; LAKS, J.; JACOB-FILHO, W.; PASQUALLUCCI, C.; GRINBERG, L.; FERREIRA, S.; PANIZZUTTI, R.- Unrevealing the role of a frontotemporal dementia protein (TDP-43 protein) in bipolar disorder(2019) NASCIMENTO, C.; VILLELA, P. Nunes; KIM, H. Kyunghee; OLIVEIRA, K. De; LEITE, R. E. Paraizo; FERRETTI-REBUSTINI, R. E. D. L.; GRINBERG, L. T.; SUEMOTO, C. K.; PASQUALUCCI, C. A.; NITRINI, R.; JACOB-FILHO, W.; BRENTANI, H. P.; LAFER, B.
conferenceObject Inflammation in the Perivascular Adipose Tissue is Associated With Coronary Artery Disease: An Autopsy Study(2015) FARIAS, Daniela S.; PASQUALUCCI, Carlos A.; NISHIZAWA, Aline; SILVA, Luiz F.; CAMPOS, Fernanda M.; SILVA, Karen C.; CUELHO, Anderson; LEITE, Renata E.; FERRETTI-REBUSTINI, Renata E.; GRINBERG, Lea T.; FARREL, Jose M.; JACOB-FILHO, Wilson; SUEMOTO, Claudia K.conferenceObject Human microglia transcriptome and cross-species analysis(2015) GALATRO, T. F. de A.; HOLTMAN, I. R.; BROUWER, N.; SOLA, P.; REIS, G. N.; VAINCHTEIN, I. D.; VERAS, M.; PEREIRA, T.; PASQUALUCCI, C.; SOGAYAR, M. C.; BODDEKE, E. W. G.; MARIE, S. K. N.; EGGEN, B. J. L.
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