ALEXANDRE FOGACA CRISTANTE

(Fonte: Lattes)
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Lattes
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Departamento de Ortopediae Traumatologia, Faculdade de Medicina - Docente
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina

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  • article
    Consensus of Clinical Neurorestorative Progress in Patients With Complete Chronic Spinal Cord Injury
    (2014) HUANG, Hongyun; SUN, Tiansheng; CHEN, Lin; MOVIGLIA, Gustavo; CHERNYKH, Elena; WILD, Klaus von; DEDA, Haluk; KANG, Kyung-Sun; KUMAR, Anand; JEON, Sang Ryong; ZHANG, Shaocheng; BRUNELLI, Giorgio; BOHBOT, Albert; SOLER, Maria Dolors; LI, Jianjun; CRISTANTE, Alexandre Fogaca; XI, Haitao; ONOSE, Gelu; KERN, Helmut; CARRARO, Ugo; SABERI, Hooshang; SHARMA, Hari Shanker; SHARMA, Alok; HE, Xijing; MURESANU, Dafin; FENG, Shiqing; OTOM, Ali; WANG, Dajue; IWATSU, Koichi; LU, Jike; AL-ZOUBI, Adeeb
    Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, ""nothing can be done."" The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation.
  • article 15 Citação(ões) na Scopus
    CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury
    (2020) PASCHON, Vera; CORREIA, Felipe Fernandes; MORENA, Beatriz Cintra; SILVA, Victor Allisson da; SANTOS, Gustavo Bispo dos; SILVA, Maria Cristina Carlan da; CRISTANTE, Alexandre Fogaca; WILLERTH, Stephanie Michelle; PERRIN, Florence Evelyne; KIHARA, Alexandre Hiroaki
    Spinal cord injury (SCI) causes temporary disabilities or permanent effects including neuropathic pain and spastiscity. The damage often results from , which in turn triggers the neuroinflammatory process. Neuroinflammation plays essential roles in the structural, biochemical, and cellular changes that take place in the spinal cord after the injury. Indeed, SCI activates many different signaling pathways that coordinate the resulting cellular responses. While neuroinflammation serves as a physiological reaction to harmful stimuli, it is clear that long-lasting inflammatory response leads to aggravation of the neurodegenerative processes, becoming detrimental to recovery post-injury. In this context, we present some possible therapeutic targets in these activated signaling pathways and provide new perspectives for SCI treatment based on recently developed technologies, including clustered regularly interspaced short palindromic repeats (CRISPR)-based methods (including prime editing), optogenetics, and designer receptor exclusively activated by designer drugs (DREADDs). We critically analyze the recent advances in the deployment of these methods focusing on the control of the initial neuroinflammatory response. We then propose alternatives and provide new avenues for SCI treatment based on these emerging technologies.