MARIO RODRIGUES LOUZA NETO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Neurobiological support to the diagnosis of ADHD in stimulant-naive adults: pattern recognition analyses of MRI data(2017) CHAIM-AVANCINI, T. M.; DOSHI, J.; ZANETTI, M. V.; ERUS, G.; SILVA, M. A.; DURAN, F. L. S.; CAVALLET, M.; SERPA, M. H.; CAETANO, S. C.; LOUZA, M. R.; DAVATZIKOS, C.; BUSATTO, G. F.Objective: In adulthood, the diagnosis of attention-deficit/hyperactivity disorder (ADHD) has been subject of recent controversy. We searched for a neuroanatomical signature associated with ADHD spectrum symptoms in adults by applying, for the first time, machine learning-based pattern classification methods to structural MRI and diffusion tensor imaging (DTI) data obtained from stimulant-naive adults with childhood-onset ADHD and healthy controls (HC). Method: Sixty-seven ADHD patients and 66 HC underwent high-resolution T1-weighted and DTI acquisitions. A support vector machine (SVM) classifier with a non-linear kernel was applied on multimodal image features extracted on regions of interest placed across the whole brain. Results: The discrimination between a mixed-gender ADHD subgroup and individually matched HC (n = 58 each) yielded area-under-the-curve (AUC) and diagnostic accuracy (DA) values of up to 0.71% and 66% (P = 0.003) respectively. AUC and DA values increased to 0.74% and 74% (P = 0.0001) when analyses were restricted to males (52 ADHD vs. 44 HC). Conclusion: Introvert personality traits showed independent risk effects on suicidality regardless of diagnosis status. Among high risk individuals with suicidal thoughts, higher neuroticism tendency is further associated with increased risk of suicide attempt.
conferenceObject THE BURDEN OF CAREGIVING IN A BRAZILIAN SAMPLE OF OUTPATIENTS WITH SCHIZOPHRENIA(2017) SARNO, Elaine Di; NAPOLITANO, Isabel Cristina; LOUZA, Mario R.- High IQ May ""Mask"" the Diagnosis of ADHD by Compensating for Deficits in Executive Functions in Treatment-Naive Adults With ADHD(2017) MILIONI, Ana Luiza Vidal; CHAIM, Tiffany Moukbel; CAVALLET, Mikael; OLIVEIRA, Nathalya Moleda de; ANNES, Marco; SANTOS, Bernardo dos; LOUZA, Mario; SILVA, Maria Aparecida da; MIGUEL, Carmen Silvia; SERPA, Mauricio Henriques; ZANETTI, Marcus V.; BUSATTO, Geraldo; CUNHA, Paulo JannuzziObjective: To evaluate and compare the performance of adults with ADHD with high and standard IQ in executive functions (EF) tasks. Method: We investigated the neuropsychological performance of 51 adults with ADHD, compared with 33 healthy controls (HC) while performing a wide battery of neuropsychological tests that measure executive functioning. Adults with clinical diagnosis of ADHD were divided into two groups according to their IQ level (IQ >= 110-ADHD group with more elevated IQ, and IQ < 110-ADHD group with standard IQ). Results: The ADHD group with standard IQ presented a worse executive functioning compared with the HC group in the following measures: Stroop 2 (p = .000) and 3 (p = .000), Trail Making Test (TMT) B (p = .005), Wisconsin Card-Sorting Test (WCST)-perseverative errors (p = .022) and failures to maintain set (p = .020), Continuous Performance Test (CPT)-omission errors (p = .005) and commission errors (p =.000), and Frontal Assessment Battery (FAB)-conceptualization (p = .016). The ADHD group with more elevated IQ presented only impairments in the CPT-commission errors (p = .019) when compared with the control group. Conclusion: Adults with ADHD and more elevated IQ show less evidence of executive functioning deficits compared with those with ADHD and standard IQ, suggesting that a higher degree of intellectual efficiency may compensate deficits in executive functions, leading to problems in establishing a precise clinical diagnosis.
- Fractionating Executive Functions of Adults With ADHD(2017) BUENO, Viviane Freire; SILVA, Maria Aparecida da; ALVES, Tania Maria; LOUZA, Mario Rodrigues; POMPEIA, SabineObjective: To evaluate the performance of adults with ADHD considering the fractionation of executive functions into six different domains. Method: Participants were adult ADHD patients who were not under the acute effects of medication (n = 48). Their performance was compared with that of a healthy control group (n = 20) of comparable age, education, and nonverbal intelligence quotient. The cognitive domains assessed were executive shifting, updating, inhibition of prepotent responses, dual-task performance, planning, and access to long-term memory. We also assessed the symptoms of inattention, hyperactivity/impulsivity, anxiety, and depression by validated questionnaires. Results: Compared with controls, patients reported more symptoms related to ADHD, anxiety and depression symptoms and were impaired in the shifting cost measure and phonemic fluency (measure of access to long-term memory). Conclusion: ADHD in adults selectively impaired executive shifting and access to long-term memory, domains that may alter performance in a wide range of daily tasks.
article 1 Citação(ões) na Scopus Association of ADHD with increased motor vehicle crashes(2017) LOUZA, Mario Rodrigues