MARIO RODRIGUES LOUZA NETO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
bookPart Tratamento da esquizofrenia(2021) LOUZã, Mário Rodrigues; KAYO, Monica; VIZZOTTO, Adriana Dias Barbosa; MELZER-RIBEIRO, Débora Luciana; SARNO, Elaine Scapaticio Di; OLIVEIRA, Graça Maria Ramos de; NAPOLITANO, Isabel Cristina; GOMES, Mônica Lopes; ELKIS, Helio- Cortical surface abnormalities are different depending on the stage of schizophrenia: A cross-sectional vertexwise mega-analysis of thickness, area and gyrification(2021) ROSA, Pedro Gomes Penteado; ZUGMAN, Andre; CERQUEIRA, Carlos Toledo; SERPA, Mauricio Henriques; DURAN, Fabio Luis de Souza; ZANETTI, Marcus Vinicius; BASSITT, Debora Pastore; ELKIS, Helio; CRIPPA, Jose Alexandre S.; SALLET, Paulo Clemente; GATTAZ, Wagner Farid; HALLAK, Jaime Eduardo Cecilio; LOUZA, Mario Rodrigues; GADELHA, Ary; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo Affonseca; BUSATTO FILHO, GeraldoBackground: Brain magnetic resonance imaging studies have not investigated the cortical surface comprehensively in schizophrenia subjects by assessing thickness, surface area and gyrification separately during the first episode of psychosis (FEP) or chronic schizophrenia (ChSch). Methods: We investigated cortical surface abnormalities in 137 FEP patients and 240 ChSch subjects compared to 297 Healthy Controls (HC) contributed by five cohorts. Maps showing results of vertexwise between-group comparisons of cortical thickness, area, and gyrification were produced using T1-weighted datasets processed using FreeSurfer 5.3, followed by validated quality control protocols. Results: FEP subjects showed large clusters of increased area and gyrification relative to HC in prefrontal and insuli cortices (Cohen's d: 0.049 to 0.28). These between-group differences occurred partially beyond the effect of sample. ChSch subjects displayed reduced cortical thickness relative to HC in smaller fronto-temporal foci (d:-0.73 to-0.35), but not beyond the effect of sample. Differences between FEP and HC subjects were associated with male gender, younger age, and earlier illness onset, while differences between ChSch and HC were associated with treatment-resistance and first-generation antipsychotic (FGA) intake independently of sample effect. Conclusions: Separate assessments of FEP and ChSch revealed abnormalities that differed in regional distribution, phenotypes affected and effect size. In FEP, associations of greater cortical area and gyrification abnormalities with earlier age of onset suggest an origin on anomalous neurodevelopment, while thickness reductions in ChSch are at least partially explained by treatment-resistance and FGA intake. Associations of between-group differences with clinical variables retained statistical significance beyond the effect of sample.
- Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders(2021) PATEL, Yash; PARKER, Nadine; SHIN, Jean; HOWARD, Derek; FRENCH, Leon; THOMOPOULOS, Sophia I.; POZZI, Elena; ABE, Yoshinari; ABE, Christoph; ANTICEVIC, Alan; ALDA, Martin; ALEMAN, Andre; ALLOZA, Clara; ALONSO-LANA, Silvia; AMEIS, Stephanie H.; ANAGNOSTOU, Evdokia; MCINTOSH, Andrew A.; ARANGO, Celso; ARNOLD, Paul D.; ASHERSON, Philip; ASSOGNA, Francesca; AUZIAS, Guillaume; AYESA-ARRIOLA, Rosa; BAKKER, Geor; BANAJ, Nerisa; BANASCHEWSKI, Tobias; BANDEIRA, Cibele E.; BARANOV, Alexandr; BARGALLO, Nuria; BAU, Claiton H. D.; BAUMEISTER, Sarah; BAUNE, Bernhard T.; BELLGROVE, Mark A.; BENEDETTI, Francesco; BERTOLINO, Alessandro; BOEDHOE, Premika S. W.; BOKS, Marco; BOLLETTINI, Irene; BONNIN, Caterina del Mar; BORGERS, Tiana; BORGWARDT, Stefan; BRANDEIS, Daniel; BRENNAN, Brian P.; BRUGGEMANN, Jason M.; BULOW, Robin; BUSATTO, Geraldo F.; CALDERONI, Sara; CALHOUN, Vince D.; CALVO, Rosa; CANALES-RODRIGUEZ, Erick J.; CANNON, Dara M.; CARR, Vaughan J.; CASCELLA, Nicola; CERCIGNANI, Mara; CHAIM-AVANCINI, Tiffany M.; CHRISTAKOU, Anastasia; COGHILL, David; CONZELMANN, Annette; CRESPO-FACORRO, Benedicto; CUBILLO, Ana I.; CULLEN, Kathryn R.; CUPERTINO, Renata B.; DALY, Eileen; DANNLOWSKI, Udo; DAVEY, Christopher G.; DENYS, Damiaan; DERUELLE, Christine; GIORGIO, Annabella Di; DICKIE, Erin W.; DIMA, Danai; DOHM, Katharina; EHRLICH, Stefan; ELY, Benjamin A.; ERWIN-GRABNER, Tracy; ETHOFER, Thomas; FAIR, Damien A.; FALLGATTER, Andreas J.; FARAONE, Stephen V.; FATJO-VILAS, Mar; FEDOR, Jennifer M.; FITZGERALD, Kate D.; FORD, Judith M.; FRODL, Thomas; FU, Cynthia H. Y.; FULLERTON, Janice M.; GABEL, Matt C.; GLAHN, David C.; ROBERTS, Gloria; GOGBERASHVILI, Tinatin; GOIKOLEA, Jose M.; GOTLIB, Ian H.; GOYA-MALDONADO, Roberto; GRABE, Hans J.; GREEN, Melissa J.; GREVET, Eugenio H.; GROENEWOLD, Nynke A.; GROTEGERD, Dominik; GRUBER, Oliver; GRUNER, Patricia; GUERRERO-PEDRAZA, Amalia; GUR, Raquel E.; GUR, Ruben C.; HAAR, Shlomi; HAARMAN, Bartholomeus C. M.; HAAVIK, Jan; HAHN, Tim; HAJEK, Tomas; HARRISON, Benjamin J.; HARRISON, Neil A.; HARTMAN, Catharina A.; WHALLEY, Heather C.; HESLENFELD, Dirk J.; HIBAR, Derrek P.; HILLAND, Eva; HIRANO, Yoshiyuki; HO, Tiffany C.; HOEKSTRA, Pieter J.; HOEKSTRA, Liesbeth; HOHMANN, Sarah; HONG, L. E.; HOSCHL, Cyril; HOVIK, Marie F.; HOWELLS, Fleur M.; NENADIC, Igor; JALBRZIKOWSKI, Maria; JAMES, Anthony C.; JANSSEN, Joost; JASPERS-FAYER, Fern; XU, Jian; JONASSEN, Rune; KARKASHADZE, Georgii; KING, Joseph A.; KIRCHER, Tilo; KIRSCHNER, Matthias; KOCH, Kathrin; KOCHUNOV, Peter; KOHLS, Gregor; KONRAD, Kerstin; KRAMER, Bernd; KRUG, Axel; KUNTSI, Jonna; KWON, Jun Soo; LANDEN, Mikael; LANDRO, Nils I.; LAZARO, Luisa; LEBEDEVA, Irina S.; LEEHR, Elisabeth J.; LERA-MIGUEL, Sara; LESCH, Klaus-Peter; LOCHNER, Christine; LOUZA, Mario R.; LUNA, Beatriz; LUNDERVOLD, Astri J.; MACMASTER, Frank P.; MAGLANOC, Luigi A.; MALPAS, Charles B.; PORTELLA, Maria J.; MARSH, Rachel; MARTYN, Fiona M.; MATAIX-COLS, David; MATHALON, Daniel H.; MCCARTHY, Hazel; MCDONALD, Colm; MCPHILEMY, Genevieve; MEINERT, Susanne; MENCHON, Jose M.; MINUZZI, Luciano; MITCHELL, Philip B.; MORENO, Carmen; MORGADO, Pedro; MURATORI, Filippo; MURPHY, Clodagh M.; MURPHY, Declan; MWANGI, Benson; NABULSI, Leila; NAKAGAWA, Akiko; NAKAMAE, Takashi; NAMAZOVA, Leyla; NARAYANASWAMY, Janardhanan; JAHANSHAD, Neda; NGUYEN, Danai D.; NICOLAU, Rosa; TUURA, Ruth L. O'Gorman; O'HEARN, Kirsten; OOSTERLAAN, Jaap; OPEL, Nils; OPHOFF, Roel A.; ORANJE, Bob; FOZ, Victor Ortiz Garcia de la; OVERS, Bronwyn J.; PALOYELIS, Yannis; PANTELIS, Christos; PARELLADA, Mara; PAULI, Paul; PICO-PEREZ, Maria; PICON, Felipe A.; PIRAS, Fabrizio; PIRAS, Federica; PLESSEN, Kerstin J.; POMAROL-CLOTET, Edith; PREDA, Adrian; PUIG, Olga; QUIDE, Yann; RADUA, Joaquim; RAMOS-QUIROGA, J. Antoni; RASSER, Paul E.; RAUER, Lisa; REDDY, Janardhan; REDLICH, Ronny; REIF, Andreas; RENEMAN, Liesbeth; REPPLE, Jonathan; RETICO, Alessandra; RICHARTE, Vanesa; RICHTER, Anja; ROSA, Pedro G. P.; RUBIA, Katya K.; HASHIMOTO, Ryota; SACCHET, Matthew D.; SALVADOR, Raymond; SANTONJA, Javier; SARINK, Kelvin; SARRO, Salvador; SATTERTHWAITE, Theodore D.; SAWA, Akira; SCHALL, Ulrich; SCHOFIELD, Peter R.; SCHRANTEE, Anouk; SEITZ, Jochen; SERPA, Mauricio H.; SETIEN-SUERO, Esther; SHAW, Philip; SHOOK, Devon; SILK, Tim J.; SIM, Kang; SIMON, Schmitt; SIMPSON, Helen Blair; SINGH, Aditya; SKOCH, Antonin; SKOKAUSKAS, Norbert; SOARES, Jair C.; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; SPANIEL, Filip; LAWRIE, Stephen M.; STERN, Emily R.; STEWART, S. Evelyn; TAKAYANAGI, Yoichiro; TEMMINGH, Henk S.; TOLIN, David F.; TOMECEK, David; TORDESILLAS-GUTIERREZ, Diana; TOSETTI, Michela; UHLMANN, Anne; AMELSVOORT, Therese van; WEE, Nic J. A. van der; WERFF, Steven J. A. van der; HAREN, Neeltje E. M. van; WINGEN, Guido A. van; VANCE, Alasdair; VAZQUEZ-BOURGON, Javier; VECCHIO, Daniela; VENKATASUBRAMANIAN, Ganesan; VIETA, Eduard; VILARROYA, Oscar; VIVES-GILABERT, Yolanda; VOINESKOS, Aristotle N.; VOLZKE, Henry; POLIER, Georg G. von; WALTON, Esther; WEICKERT, Thomas W.; WEICKERT, Cynthia Shannon; WEIDEMAN, Andrea S.; WITTFELD, Katharina; WOLF, Daniel H.; WU, Mon-Ju; YANG, T. T.; YANG, Kun; YONCHEVA, Yuliya; YUN, Je-Yeon; CHENG, Yuqi; ZANETTI, Marcus V.; ZIEGLER, Georg C.; FRANKE, Barbara; HOOGMAN, Martine; BUITELAAR, Jan K.; ROOIJ, Daan van; ANDREASSEN, Ole A.; CHING, Christopher R. K.; VELTMAN, Dick J.; SCHMAAL, Lianne; STEIN, Dan J.; HEUVEL, Odile A. van den; TURNER, Jessica A.; ERP, Theo G. M. van; PAUSOVA, Zdenka; THOMPSON, Paul M.; PAUS, TomasImportance Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. Objective To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. Design, Setting, and Participants Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244. Main Outcomes and Measures Interregional profiles of group difference in cortical thickness between cases and controls. Results A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders. Conclusions and Relevance In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders. Question What are the neurobiologic underpinnings of group differences in cortical thickness in various psychiatric disorders? Findings In this consortium analysis of data from 145 cohorts, regions of the cerebral cortex with greater expression of genes specific to pyramidal (CA1) cells were also regions with greater case-control group differences in cortical thickness in all 6 disorders: attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, and schizophrenia. There was a common profile of group differences in cortical thickness shared among these disorders, which was associated with the expression of genes involved in neurodevelopmental processes (prenatally) and processes underlying synaptic activity and plasticity (postnatally). Meaning There are shared neurobiologic and cellular mechanisms associated with differences in cortical thickness across multiple psychiatric disorders, implicating a common role of prenatal development and postnatal functioning of the cerebral cortex. This study evaluates neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 psychiatric disorders.
bookPart Esquizofrenia(2021) ELKIS, Helio; KAYO, Monica; FREITAS, Rosana Ramos de; OLIVEIRA, Graça Maria Ramos de; LEITE, Samuel Araujo; FORTES, Marisa; PANTAROTTO, Ivania; LOUZã, Mario Rodrigues- Gray Matter Volume in Elderly adults With ADHD: Associations of Symptoms and Comorbidities With Brain Structures(2021) KLEIN, Margarete; SOUZA-DURAN, Fabio Luis; MENEZES, Anny Karinna Pires Mendes; ALVES, Tania Maria; BUSATTO, Geraldo; LOUZA, Mario R.Objective: To investigate total and selected region-of-interest-based gray matter volume (GMV) in older adults with ADHD. Method: Twenty-five elderly (>= 65 years old) patients with ADHD and 34 healthy controls underwent 1.5-T magnetic resonance imaging (MRI). We used voxel-based morphometry to compare GMV between groups and performed a correlation analysis with ADHD symptoms and comorbidities. Results: Findings revealed a smaller total GMV in males with ADHD and a smaller GMV in the right medial frontal orbital area extending toward the medial frontal superior, the frontal superior, and the subgenual anterior cingulate cortex (ACC) besides correlations between inattentiveness and ACC (bilaterally) and left cerebellum, hyperactivity/impulsivity and the left frontal inferior orbital, depression and caudate (bilaterally), and the right inferior parietal lobule. Conclusion: Neural correlates in regions related to attention, executive control, and affective processing suggest that impairments in frontostriatal and frontoparietal-cerebellar areas observed in adults with ADHD persist into old age.
- Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets(2021) POSTEMA, Merel C.; HOOGMAN, Martine; AMBROSINO, Sara; ASHERSON, Philip; BANASCHEWSKI, Tobias; BANDEIRA, Cibele E.; BARANOV, Alexandr; BAU, Claiton H. D.; BAUMEISTER, Sarah; BAUR-STREUBEL, Ramona; BELLGROVE, Mark A.; BIEDERMAN, Joseph; BRALTEN, Janita; BRANDEIS, Daniel; BREM, Silvia; BUITELAAR, Jan K.; BUSATTO, Geraldo F.; CASTELLANOS, Francisco X.; CERCIGNANI, Mara; CHAIM-AVANCINI, Tiffany M.; CHANTILUKE, Kaylita C.; CHRISTAKOU, Anastasia; COGHILL, David; CONZELMANN, Annette; CUBILLO, Ana I.; CUPERTINO, Renata B.; ZEEUW, Patrick de; DOYLE, Alysa E.; DURSTON, Sarah; EARL, Eric A.; EPSTEIN, Jeffery N.; ETHOFER, Thomas; FAIR, Damien A.; FALLGATTER, Andreas J.; FARAONE, Stephen V.; FRODL, Thomas; GABEL, Matt C.; GOGBERASHVILI, Tinatin; GREVET, Eugenio H.; HAAVIK, Jan; HARRISON, Neil A.; HARTMAN, Catharina A.; HESLENFELD, Dirk J.; HOEKSTRA, Pieter J.; HOHMANN, Sarah; HOVIK, Marie F.; JERNIGAN, Terry L.; KARDATZKI, Bernd; KARKASHADZE, Georgii; KELLY, Clare; KOHLS, Gregor; KONRAD, Kerstin; KUNTSI, Jonna; LAZARO, Luisa; LERA-MIGUEL, Sara; LESCH, Klaus-Peter; LOUZA, Mario R.; LUNDERVOLD, Astri J.; MALPAS, Charles B.; MATTOS, Paulo; MCCARTHY, Hazel; NAMAZOVA-BARANOVA, Leyla; NICOLAU, Rosa; NIGG, Joel T.; NOVOTNY, Stephanie E.; WEISS, Eileen Oberwelland; TUURA, Ruth L. O'Gorman; OOSTERLAAN, Jaap; ORANJE, Bob; PALOYELIS, Yannis; PAULI, Paul; PICON, Felipe A.; PLESSEN, Kerstin J.; RAMOS-QUIROGA, J. Antoni; REIF, Andreas; RENEMAN, Liesbeth; ROSA, Pedro G. P.; RUBIA, Katya; SCHRANTEE, Anouk; SCHWEREN, Lizanne J. S.; SEITZ, Jochen; SHAW, Philip; SILK, Tim J.; SKOKAUSKAS, Norbert; VILA, Juan C. Soliva; STEVENS, Michael C.; SUDRE, Gustavo; TAMM, Leanne; TOVAR-MOLL, Fernanda; ERP, Theo G. M. van; VANCE, Alasdair; VILARROYA, Oscar; VIVES-GILABERT, Yolanda; POLIER, Georg G. von; WALITZA, Susanne; YONCHEVA, Yuliya N.; ZANETTI, Marcus V.; ZIEGLER, Georg C.; GLAHN, David C.; JAHANSHAD, Neda; MEDLAND, Sarah E.; THOMPSON, Paul M.; FISHER, Simon E.; FRANKE, Barbara; FRANCKS, ClydeObjective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.