MARIO RODRIGUES LOUZA NETO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- A Multicenter, Open-Label Trial to Evaluate the Quality of Life in Adults With ADHD Treated With Long-Acting Methylphenidate (OROS MPH): Concerta Quality of Life (CONQoL) Study(2013) MATTOS, Paulo; LOUZA, Mario Rodrigues; PALMINI, Andre Luis Fernandes; OLIVEIRA, Irismar Reis de; ROCHA, Fabio LopesThe available literature provides few studies on the effectiveness of methylphenidate in improving quality of life in individuals with ADHD. Objective: To assess the effectiveness of Methyphenidate OROS formulation (OROS MPH) through QoL in adults with ADHD. Method: A 12-week, multicenter, open-label trial involving 60 patients was used. The measures used were Adult Self-Rating Scale, Adult ADHD Quality of Life Scale (AAQoL), State and Trait Anxiety Inventory (STAI), Hamilton Depression Rating Scale (HAM-D), Clinical Global Impression (CGI), and safety measures. A significance statistic level of 5% was adopted. Results: Analyses included 60 patients (66.7% male; M age = 31.1 years) for safety and 58 patients for effectiveness. All AAQoL subscales improved from baseline to Week 12 (p < .0001), as well as the Total AAQoL (p < .0001). A significant reduction on Clinical Global Impression-Improvement (CGI-I), HAM-D, STAI, and ASRS scores was observed (p < .0001). No serious adverse event was reported. Conclusion: Treatment of adult ADHD patients with OROS MPH improves QoL.
- Lack of Association Between a 3 ' UTR VNTR Polymorphism of Dopamine Transporter Gene (SLC6A3) and ADHD in a Brazilian Sample of Adult Patients(2011) SILVA, Maria Aparecida da; CORDEIRO, Quirino; LOUZA, Mario; VALLADA, HomeroObjective: To investigate a possible association between a 3'UTR VNTR polymorphism of the dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of adult patients. Method: Study Case-control with 102 ADHD adult outpatients (DSM-IV criteria) and 479 healthy controls. The primers' sequence used were: 3'UTR-Forward: 5'TGT GGT GAT GGG AAC GGC CTG AG 3' and 3'UTR-Reverse: 5'CTT CCT GGA GGT CAC GGC TCA AGG 3'. Alleles of the 3'UTR were coded according to their number of repeats: 6- repeat 320 bp (allele 6), 8- repeat 400 bp (allele 8), 9-repeat 480 bp (allele 9), 10- repeat 480 bp (allele 10), and 11- repeat 520 bp (allele 11). Results: There were no allelic (chi(2) = 2.67, 5df, p = .75) and genotypic (chi(2) = 7.20, 1df, p = .61) association between adult ADHD and VNTR 3'UTR polymorphism of SLC6A3. Conclusion: Our findings do not support SLC6A3 as marker genetic susceptibility factor in adult ADHD. More comprehensive polymorphism coverage within the SLC6A3 region should be conducted in larger samples, including comparisons in clinical subgroups, and in samples with different ethnic backgrounds. (J. of Att. Dis. 2011; 15(4) 305-309)
- Gray Matter Volume in Elderly adults With ADHD: Associations of Symptoms and Comorbidities With Brain Structures(2021) KLEIN, Margarete; SOUZA-DURAN, Fabio Luis; MENEZES, Anny Karinna Pires Mendes; ALVES, Tania Maria; BUSATTO, Geraldo; LOUZA, Mario R.Objective: To investigate total and selected region-of-interest-based gray matter volume (GMV) in older adults with ADHD. Method: Twenty-five elderly (>= 65 years old) patients with ADHD and 34 healthy controls underwent 1.5-T magnetic resonance imaging (MRI). We used voxel-based morphometry to compare GMV between groups and performed a correlation analysis with ADHD symptoms and comorbidities. Results: Findings revealed a smaller total GMV in males with ADHD and a smaller GMV in the right medial frontal orbital area extending toward the medial frontal superior, the frontal superior, and the subgenual anterior cingulate cortex (ACC) besides correlations between inattentiveness and ACC (bilaterally) and left cerebellum, hyperactivity/impulsivity and the left frontal inferior orbital, depression and caudate (bilaterally), and the right inferior parietal lobule. Conclusion: Neural correlates in regions related to attention, executive control, and affective processing suggest that impairments in frontostriatal and frontoparietal-cerebellar areas observed in adults with ADHD persist into old age.
- Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets(2021) POSTEMA, Merel C.; HOOGMAN, Martine; AMBROSINO, Sara; ASHERSON, Philip; BANASCHEWSKI, Tobias; BANDEIRA, Cibele E.; BARANOV, Alexandr; BAU, Claiton H. D.; BAUMEISTER, Sarah; BAUR-STREUBEL, Ramona; BELLGROVE, Mark A.; BIEDERMAN, Joseph; BRALTEN, Janita; BRANDEIS, Daniel; BREM, Silvia; BUITELAAR, Jan K.; BUSATTO, Geraldo F.; CASTELLANOS, Francisco X.; CERCIGNANI, Mara; CHAIM-AVANCINI, Tiffany M.; CHANTILUKE, Kaylita C.; CHRISTAKOU, Anastasia; COGHILL, David; CONZELMANN, Annette; CUBILLO, Ana I.; CUPERTINO, Renata B.; ZEEUW, Patrick de; DOYLE, Alysa E.; DURSTON, Sarah; EARL, Eric A.; EPSTEIN, Jeffery N.; ETHOFER, Thomas; FAIR, Damien A.; FALLGATTER, Andreas J.; FARAONE, Stephen V.; FRODL, Thomas; GABEL, Matt C.; GOGBERASHVILI, Tinatin; GREVET, Eugenio H.; HAAVIK, Jan; HARRISON, Neil A.; HARTMAN, Catharina A.; HESLENFELD, Dirk J.; HOEKSTRA, Pieter J.; HOHMANN, Sarah; HOVIK, Marie F.; JERNIGAN, Terry L.; KARDATZKI, Bernd; KARKASHADZE, Georgii; KELLY, Clare; KOHLS, Gregor; KONRAD, Kerstin; KUNTSI, Jonna; LAZARO, Luisa; LERA-MIGUEL, Sara; LESCH, Klaus-Peter; LOUZA, Mario R.; LUNDERVOLD, Astri J.; MALPAS, Charles B.; MATTOS, Paulo; MCCARTHY, Hazel; NAMAZOVA-BARANOVA, Leyla; NICOLAU, Rosa; NIGG, Joel T.; NOVOTNY, Stephanie E.; WEISS, Eileen Oberwelland; TUURA, Ruth L. O'Gorman; OOSTERLAAN, Jaap; ORANJE, Bob; PALOYELIS, Yannis; PAULI, Paul; PICON, Felipe A.; PLESSEN, Kerstin J.; RAMOS-QUIROGA, J. Antoni; REIF, Andreas; RENEMAN, Liesbeth; ROSA, Pedro G. P.; RUBIA, Katya; SCHRANTEE, Anouk; SCHWEREN, Lizanne J. S.; SEITZ, Jochen; SHAW, Philip; SILK, Tim J.; SKOKAUSKAS, Norbert; VILA, Juan C. Soliva; STEVENS, Michael C.; SUDRE, Gustavo; TAMM, Leanne; TOVAR-MOLL, Fernanda; ERP, Theo G. M. van; VANCE, Alasdair; VILARROYA, Oscar; VIVES-GILABERT, Yolanda; POLIER, Georg G. von; WALITZA, Susanne; YONCHEVA, Yuliya N.; ZANETTI, Marcus V.; ZIEGLER, Georg C.; GLAHN, David C.; JAHANSHAD, Neda; MEDLAND, Sarah E.; THOMPSON, Paul M.; FISHER, Simon E.; FRANKE, Barbara; FRANCKS, ClydeObjective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
- High IQ May ""Mask"" the Diagnosis of ADHD by Compensating for Deficits in Executive Functions in Treatment-Naive Adults With ADHD(2017) MILIONI, Ana Luiza Vidal; CHAIM, Tiffany Moukbel; CAVALLET, Mikael; OLIVEIRA, Nathalya Moleda de; ANNES, Marco; SANTOS, Bernardo dos; LOUZA, Mario; SILVA, Maria Aparecida da; MIGUEL, Carmen Silvia; SERPA, Mauricio Henriques; ZANETTI, Marcus V.; BUSATTO, Geraldo; CUNHA, Paulo JannuzziObjective: To evaluate and compare the performance of adults with ADHD with high and standard IQ in executive functions (EF) tasks. Method: We investigated the neuropsychological performance of 51 adults with ADHD, compared with 33 healthy controls (HC) while performing a wide battery of neuropsychological tests that measure executive functioning. Adults with clinical diagnosis of ADHD were divided into two groups according to their IQ level (IQ >= 110-ADHD group with more elevated IQ, and IQ < 110-ADHD group with standard IQ). Results: The ADHD group with standard IQ presented a worse executive functioning compared with the HC group in the following measures: Stroop 2 (p = .000) and 3 (p = .000), Trail Making Test (TMT) B (p = .005), Wisconsin Card-Sorting Test (WCST)-perseverative errors (p = .022) and failures to maintain set (p = .020), Continuous Performance Test (CPT)-omission errors (p = .005) and commission errors (p =.000), and Frontal Assessment Battery (FAB)-conceptualization (p = .016). The ADHD group with more elevated IQ presented only impairments in the CPT-commission errors (p = .019) when compared with the control group. Conclusion: Adults with ADHD and more elevated IQ show less evidence of executive functioning deficits compared with those with ADHD and standard IQ, suggesting that a higher degree of intellectual efficiency may compensate deficits in executive functions, leading to problems in establishing a precise clinical diagnosis.
- Ego Defense Mechanisms and Types of Object Relations in Adults With ADHD(2016) SILVA, Vanessa de Almeida; LOUZA, Mario Rodrigues; SILVA, Maria Aparecida da; NAKANO, Eduardo YoshioObjective: This research evaluates the personality structure of adults with ADHD from a psychodynamic perspective. The hypothesis was that possible structural characteristics in personality could be correlated with this syndrome. Method: Assessment tools for ego functions (Bell Object Relations and Reality Testing Inventory [BORRTI-Form O], Defense Style Questionnaire ( DSQ-40)) were applied to a sample of 90 adults with ADHD, recruited in a specialized clinic. Results: Among the ADHD sample, 84.4% of the participants were identified as having object relations pathologies. Pathological elevations were observed mainly in the Alienation, Egocentricity, and Insecure Attachment subscales. Statistically, significant differences were found especially in the use of immature and neurotic defense mechanisms, compared with normative data. Conclusion: The findings indicate that adults with ADHD make more use of immature and neurotic defense mechanisms, and presented pathological internalized object relations that are typical of an archaic and poorly structured egoic structure.
- Fractionating Executive Functions of Adults With ADHD(2017) BUENO, Viviane Freire; SILVA, Maria Aparecida da; ALVES, Tania Maria; LOUZA, Mario Rodrigues; POMPEIA, SabineObjective: To evaluate the performance of adults with ADHD considering the fractionation of executive functions into six different domains. Method: Participants were adult ADHD patients who were not under the acute effects of medication (n = 48). Their performance was compared with that of a healthy control group (n = 20) of comparable age, education, and nonverbal intelligence quotient. The cognitive domains assessed were executive shifting, updating, inhibition of prepotent responses, dual-task performance, planning, and access to long-term memory. We also assessed the symptoms of inattention, hyperactivity/impulsivity, anxiety, and depression by validated questionnaires. Results: Compared with controls, patients reported more symptoms related to ADHD, anxiety and depression symptoms and were impaired in the shifting cost measure and phonemic fluency (measure of access to long-term memory). Conclusion: ADHD in adults selectively impaired executive shifting and access to long-term memory, domains that may alter performance in a wide range of daily tasks.