LUCIANA OBA ONISHI KIKUCHI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Early Age Hepatocellular Carcinoma Associated With Hepatitis B Infection in South America(2017) CHAN, Aaron J.; BALDERRAMO, Domingo; KIKUCHI, Luciana; BALLERGA, Esteban Gonzalez; PRIETO, Jhon E.; TAPIAS, Monica; IDROVO, Victor; DAVALOS, Milagros B.; CAIRO, Fernando; BARREYRO, Fernando J.; PAREDES, Sebastian; HERNANDEZ, Nelia; AVENDANO, Karla; FERRER, Javier Diaz; YANG, Ju Dong; CARRERA, Enrique; MATTOS, Angelo Z.; HIRSCH, Bruno S.; GONCALVES, Pablo T.; CARRILHO, Flair J.; ROBERTS, Lewis R.; DEBES, Jose D.
conferenceObject Hepatitis B and C as Risk Factors for Early Hepatocellular Carcinoma Across South America(2016) CHAN, Aaron J.; BALDERRAMO, Domingo; KIKUCHI, Luciana; BALLERGA, Esteban Gonzalez; PRIETO, Jhon; TAPIAS, Monica; IDROVO, Victor; DAVALOS, Milagros; CAIRO, Fernando; BARREYRO, Fernando; PAREDES, Sebastian; HERNANDEZ, Nelia; AVENDANO, Karla; FERRER, Javier Diaz; YANG, Ju Dong; CARRERA, Enrique; RODRIGUEZ, Pablo; HIRSCH, Bruno; MATTOS, Angelo Z.; CARRILHO, Flair J.; ROBERTS, Lewis R.; DEBES, Jose- Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy(2018) DEBES, Jose D.; CHAN, Aaron J.; BALDERRAMO, Domingo; KIKUCHI, Luciana; BALLERGA, Esteban Gonzalez; PRIETO, Jhon E.; TAPIAS, Monica; IDROVO, Victor; DAVALOS, Milagros B.; CAIRO, Fernando; BARREYRO, Fernando J.; PAREDES, Sebastian; HERNANDEZ, Nelia; AVENDANO, Karla; FERRER, Javier Diaz; YANG, Ju Dong; CARRERA, Enrique; GARCIA, Jairo A.; MATTOS, Angelo Z.; HIRSCH, Bruno S.; GONCALVES, Pablo T.; CARRILHO, Flair J.; ROBERTS, Lewis R.Background & AimsHepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies addressing the epidemiology of HCC originate from developed countries. This study reports the preliminary findings of a multinational approach to characterize HCC in South America. MethodsWe evaluated 1336 HCC patients seen at 14 centres in six South American countries using a retrospective study design with participating centres completing a template chart of patient characteristics. The diagnosis of HCC was made radiographically or histologically for all cases according to institutional standards. Methodology of surveillance for each centre was following AASLD or EASL recommendations. ResultsSixty-eight percent of individuals were male with a median age of 64years at time of diagnosis. The most common risk factor for HCC was hepatitis C infection (HCV, 48%), followed by alcoholic cirrhosis (22%), Hepatitis B infection (HBV, 14%) and NAFLD (9%). We found that among individuals with HBV-related HCC, 38% were diagnosed before age 50. The most commonly provided therapy was transarterial chemoembolization (35% of HCCs) with few individuals being considered for liver transplant (<20%). Only 47% of HCCs were diagnosed during surveillance, and there was no difference in age of diagnosis between those diagnosed incidentally vs by surveillance. Nonetheless, being diagnosed during surveillance was associated with improved overall survival (P=.01). ConclusionsOur study represents the largest cohort to date reporting characteristics and outcomes of HCC across South America. We found an important number of HCCs diagnosed outside of surveillance programmes, with associated increased mortality in those patients.
conferenceObject Hepatocellular Carcinoma in South America: Evaluating Factors for Curative Therapy and Survival(2016) CHAN, Aaron; BALLERGA, Esteban; KIKUCHI, Luciana; PRIETO, Jhon Edison; TAPIAS, Monica; IDROVO, Victor; DAVALOS, Milagros; CAIRO, Fernando; BARREYRO, Fernando; PAREDES, Sebastian; HIRSCH, Bruno; GONCALVES, Pablo Rodrigues; HERNANDEZ, Nelia; AVENDANO, Karla; FERRER, Javier Diaz; YANG, Ju Dong; CARRERA, Enrique; BALDERRAMO, Domingo; MATTOS, Angelo Z.; CARRILHO, Flair Jose; ROBERTS, Lewis R.; DEBES, Jose D.conferenceObject Sorafenib Therapy in HIV-infected Patients with Hepatocellular Carcinoma (HCC)(2015) KIKUCHI, Luciana; CITTI, Caitlin C.; CHEN, Ting-Yi; PLATT, Heather L.; KAPLAN, David E.; VENTURA-COTS, Meritxell; JAIN, Mamta K.; VISPO, Eugenia; DARUICH, Jorge; NUNEZ, Marina; BARREIRO, Pablo; MINGUEZ, Beatriz; AYTAMAN, Ayse; RIMLAND, David; BRAEU, Norbert