RUI IMAMURA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
14 resultados
Resultados de Busca
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- Extracellular Matrix Composition of the Cricopharyngeus Muscle(2012) TAVARES, Raquel Aguiar; SENNES, Luiz Ubirajara; MAUAD, Thais; IMAMURA, Rui; SILVA, Luiz Fernando Ferraz da; CARRAU, Ricardo LuisThe aim of this study was to analyze the presence and distribution of total collagen, type I and type III collagen, elastic fibers, fibronectin, and versican in the endomysium of cricopharyngeus muscles from adults of various ages. The study was a cross-sectional analysis of human cricopharyngeus muscles. Twenty-seven muscles obtained from autopsies of men and women ranging in age from 28 to 92 years were analyzed with the Picrosirius method, oxidized Weigert resorcin-fuchsin, immunohistochemistry, and image analysis. Collagen had the highest density among the analyzed components. Elastic fibers surrounded each muscle cell; they were aligned longitudinally by their long axis and associated with traversing fibers, thereby forming a fiber network with embedded muscle cells. The fibronectin and versican contents varied widely among the specimens. We found no statistically significant differences between the proportion of extracellular matrix (ECM) components and factors such as gender and race. We conclude that the higher proportion of type I and type III collagen is compatible with the cricopharyngeus muscle's sphincteric behavior, and the arrangement of the elastic fibers may also contribute to the muscle's elasticity. We found no statistically significant correlation between the ECM components and age.
- Influence of international authorship on citations in Brazilian medical journals: a bibliometric analysis(2019) MONTEFUSCO, Adilson Marcos; NASCIMENTO, Felipe Parra do; SENNES, Luiz Ubirajara; BENTO, Ricardo Ferreira; IMAMURA, RuiThe challenge of increasing the impact of regional journals has received much attention. While funding and research agencies require the acceptance of papers from foreign authors as a means of increasing citations, Brazilian journal editors dispute the impact of this measure. This study aimed to evaluate, for Brazilian medical journals, whether the number of citations a document received was influenced by the authors' institutional affiliations or other predictive factors related to the paper or the journal. Sixty-one medical journals published in Brazil in 2012 were selected for analysis. SCImago and Scopus were used to extract the articles and their data. The number of citations a document received in 5years was analyzed according to the authors' affiliations, language, document type, SCImago Cites per Document, and journal subject category. After adjusting for covariates by multivariate analysis, documents with collaborative international affiliations showed a citation increase of 0.17 (95% CI: 0.084-0.216) over documents by Brazilian authors. Significant increases in citations were also observed for bilingual documents (0.329; 95% CI: 0.236-0.380), English-only documents (0.159; 95% CI: 0.078-0.203), articles (1.590; 95% CI: 1.363-1.714), reviews (2.752; 95% CI: 2.355-2.972), and those under the subject category of hematology (1.280; 95% CI: 0.756-1.604). In summary, while collaborative international authorship increased citations in the investigated journals, language, type of document, and subject category had a stronger impact on the number of citations.
bookPart Tireoplastias: princípios e técnicas(2022) TSUJI, Domingos Hiroshi; IMAMURA, Rui; SENNES, Luiz Ubirajara- Bipedicled Vocal Fold Mucosal Flap Use in Phonomicrosurgery: Case Series(2021) TSUJI, Domingos Hiroshi; KINCHOKU, Vanessa Mika; IMAMURA, Rui; HACHIYA, Adriana; YAMASAKI, Rosiane; MARINHO, Guilherme Rodrigues; SENNES, Luiz UbirajaraObjectives. The objective of this study was to present a novel surgical technique involving the use of a ""bipedicled vocal fold mucosal flap"" to repair a mucosal defect and to evaluate the outcomes of patients in whom it was used. Material and methods. This was a retrospective study of 6 clinical cases. All patients underwent surgery between November 2000 and July 2018, and all procedures were performed by the same surgeon. For the auditory-perceptual assessment, the Grade-Roughness-Breathiness-Asthenia-Strain hoarseness scale was used. We based the stroboscopic evaluation on the European Laryngological Society protocol, analyzing the parameters glottal closure, mucosal wave, and phase symmetry. Results. Ages at the time of surgery ranged from 10 to 52 years, and all of the patients were male. Preexisting vocal fold lesions included polyps, cysts, a sulcus, and mucosal bridges. Among the stroboscopic parameters, only the mucosal wave differed significantly between the preoperative and postoperative periods (P = 0.046). There were also significant postoperative improvements in the overall grade of dysphonia (P = 0.025) and in the degree of breathiness (P = 0.025). Conclusions. The use of a bipedicled vocal fold mucosal flap appears to promote significant improvements in the mucosal wave and in voice quality. In the patients evaluated here, the technique was used without preoperative planning. However, it proved to be a safe and appropriate means of repairing mucosal defects in the vocal folds, with the potential to preserve rheological properties and promote healing with less chance of fibrosis.
bookPart Doenças das Glândulas Salivares(2016) SENNES, Luiz Ubirajara; IMAMURA, Rui; REZENDE, Sérgio EdrianebookPart Sintomas extraesofágicos da doença do refluxo gastroesofágico(2018) SENNES, Luiz Ubirajara; COSTA, Luciana Fernandes; FIGUEIREDO, Luiz Antonio Prata de; IMAMURA, RuibookPart Microlaringoscopia de suspensão (princípios básicos, instrumentais e técnica)(2022) SENNES, Luiz Ubirajara; TSUJI, Domingos Hiroshi; IMAMURA, Rui- Endoscopic Laser Thyroarytenoid Myoneurectomy in Patients with Adductor Spasmodic Dysphonia: A Pilot Study on Long-Term Outcome on Voice Quality(2012) TSUJI, Domingos Hiroshi; TAKAHASHI, Marystella Tomoe; IMAMURA, Rui; HACHIYA, Adriana; SENNES, Luiz UbirajaraObjectives. Adductor spasmodic dysphonia (ADSD) is a focal laryngeal dystonia, which compromises greatly the quality of life of the patients involved. It is a severe vocal disorder characterized by spasms of laryngeal muscles during speech, producing phonatory breaks, forced, strained and strangled voice. Its symptoms result from involuntary and intermittent contractions of thyroarytenoid muscle during speech, which causes vocal fold to strain, pressing each vocal fold against the other and increasing glottic resistance. Botulinum toxin injection remains the gold-standard treatment. However, as injections should be repeated periodically leading to voice quality instability, a more definitive procedure would be desirable. In this pilot study we report the long-term vocal quality results of endoscopic laser thyroarytenoid myoneurectomy. Study Design. Prospective study. Methods. Surgery was performed in 15 patients (11 females and four males), aged between 29 and 73 years, diagnosed with ADSD. Voice Handicap Index (VHI) was obtained before and after surgery (median 31 months postoperatively). Results. A significant improvement in VHI was observed after surgery, as compared with baseline values (P = 0.001). The median and interquartile range for preoperative VHI was 99 and 13, respectively and 24 and 42, for postoperative VHI. Subjective improvement of voice as assessed by the patients showed median improvement of 80%. Conclusions. Because long-term follow-up showed significant improvement of voice quality, this innovative surgical technique seems a satisfactory alternative treatment of ADSD patients who seek a definite improvement of their condition.
- Diffusion of aniline blue injected into the thyroarytenoid muscle as a proxy for botulinum toxin injection: an experimental study in cadaver larynges(2013) ALONSO, Valéria Maria de Oliveira; CHAGURY, Azis Arruda; HACHIYA, Adriana; IMAMURA, Rui; TSUJI, Domingos Hiroshi; SENNES, Luiz UbirajaraINTRODUCTION: Endolaryngeal injection of botulinum toxin into the thyroarytenoid (TA) muscle is one of the methods for treatment of focal laryngeal dystonia. However, after treatment, there is variation in laryngeal configuration as well as the side effects reported by patients. As a consequence of the functional variability of results, it was hypothesized that botulinum toxin diffuses beyond the limits of the muscle into which it is injected. OBJECTIVES: After injection of botulinum toxin into the TA muscle for the treatment of focal laryngeal dystonia, patients differ in terms of laryngeal configuration and side effects. We hypothesized that this toxin diffuses from the target muscle to adjacent muscles. METHOD: The TA muscles of 18 cadaver larynges were injected with aniline blue (0.2 mL). After fixation in formaldehyde and nitric acid decalcification, the larynges were sectioned in the coronal plane and the intrinsic muscles were analyzed. RESULTS: We found diffusion of aniline blue to the lateral cricoarytenoid muscle, cricothyroid muscle, and posterior cricoarytenoid muscle in 94.3%, 42.9%, and 8.6% of the cases, respectively. In terms of the degree of diffusion to adjacent muscles, we found no differences related to the size (height and width) of the TA muscle or to gender. CONCLUSIONS: Our findings suggest that diffusion of botulinum toxin from its injection site in the TA muscle to the lateral cricoarytenoid muscle is likely in most cases. On the other hand, diffusion to the cricothyroid muscle occurs in approximately half of cases and diffusion to the posterior cricoarytenoid muscle occurs in very few cases.
bookPart Estenose laringotraqueal(2022) SENNES, Luiz Ubirajara; IMAMURA, Rui; TSUJI, Domingos Hiroshi