CARMEN SILVIA MOLLEIS GALEGO MIZIARA
Projetos de Pesquisa
Unidades Organizacionais
LIM/40 - Laboratório de Imunohematologia e Hematologia Forense, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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- Cognitive impact in children with ""benign"" childhood focal epilepsy with centrotemporal spikes(2017) BANASKIWITZ, Natalie Helene van Cleef; MIZIARA, Carmen Silvia Molleis Galego; XAVIER, Alana Batista; MANREZA, Maria Luiza Giraldes de; TREVIZOL, Alisson Paulino; DIAS, Alvaro Machado; SERAFIM, Antonio de PaduaBackground: Cognitive alterations are associated with benign childhood focal epilepsy with centrotemporal spikes (BCECTS) including aspects of executive functions. Objectives: This study presents the performance profile on attention and executive function tests of fifty-eight children (BCECTS, n = 30 and controls, n = 28) aged 8-13 years. Methods: The following tools were employed: Vocabulary and Block Design subtests from the Wechsler Intelligence Scale for Children III, Stroop Test, Modified Card Sorting Test, Controlled Oral Word Association - FAS and Tower of London. Results: Children with BCECTS presented average IQ measure, although their performance was statistically worse when compared to the control group. Children with BCECTS showed significantly lower performance compared to the control group in the following variables: total number of recollected words on the oral fluency test, total number of categories, categorization effect and total number of errors in MCST; and execution time for the Stroop Test Card 1. After controlling for the IQ effect, the total number of errors in the MCST did not show any significant difference between the groups. Discussion: Children with BCECTS showed lower performance in attention and executive functions when compared to healthy children. The results suggest that the concept of ""benign"" BCECTS should be reconsidered.
- The Perceived Social Stigma of People with Epilepsy with regard to the Question of Employability(2018) SOUZA, Jessica Lopes de; FAIOLA, Aline Scardoeli; MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes deObjective. To evaluate the perceived social stigma of people with epilepsy with regard to the question of employability. Methods. A structured questionnaire was given to two groups of people with chronic diseases: those with epilepsy (study group) and those with heart disease (control group). The questions concerned employability. Results. Having epilepsy was more strongly associated with higher unemployment rates (p < 0.0001); job layoffs (p = 0.001); being unfit to work (p < 0.0001); feeling shame for having the disease (p = 0.014); absence of partners (p = 0.026); and depression (p = 0.004). The tendency to hide their disease from their employers was similar for the two groups. Conclusion. The age discrepancy between groups was an important limiting factor of this study. However, despite the limited number of participants and the age difference between the groups, there is no impediment in stating that people with epilepsy show high rates of unemployment, depression, and stigma.
- Time Interval between First and Last Epileptic Seizures and Electroencephalogram Normalization in Benign Childhood Epilepsy with Centrotemporal Spikes: Influencing Factors(2020) MIZIARA, Carmen Silvia Molleis Galego; MICHELETTO, Maria Laura Jorge; SERRANO, Virginia Aparecida Gelmeti; NAKANISHI, Denise Harumi; SERINOLLI, Mario Ivo; MANREZA, Maria Luiza Giraldes de; REED, Umbertina ContiThe aim of this study was to evaluate the interval between the first and last seizures, the normalization of the electroencephalogram (EEG), and to identify factors of influence. Medical records of children were analyzed with benign childhood epilepsy with centrotemporal spikes. Variables age at first and last seizure, gender, interval between the first and last seizure, the first seizure and EEG normalization, lateralization of the epileptiform discharges, and last epileptic seizure and EEG normalization. The mean time between the first and last seizure was 3.34 years. Early onset of seizures and unilateral discharges were factors that increased the interval between the first and last seizures (p < 0.001). Interval between the last seizure and EEG normalization was 2.40 years, without influence of age (p = 0.986). Interval was shorter in bilateral discharges (p = 0.035). The antiepileptic medicine did not alter the natural history of disease progression. In younger children, the interval between last seizure and normalization of the EEG is reduced compared to older children.