CARMEN SILVIA MOLLEIS GALEGO MIZIARA
Projetos de Pesquisa
Unidades Organizacionais
LIM/40 - Laboratório de Imunohematologia e Hematologia Forense, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Cognitive impact in children with ""benign"" childhood focal epilepsy with centrotemporal spikes(2017) BANASKIWITZ, Natalie Helene van Cleef; MIZIARA, Carmen Silvia Molleis Galego; XAVIER, Alana Batista; MANREZA, Maria Luiza Giraldes de; TREVIZOL, Alisson Paulino; DIAS, Alvaro Machado; SERAFIM, Antonio de PaduaBackground: Cognitive alterations are associated with benign childhood focal epilepsy with centrotemporal spikes (BCECTS) including aspects of executive functions. Objectives: This study presents the performance profile on attention and executive function tests of fifty-eight children (BCECTS, n = 30 and controls, n = 28) aged 8-13 years. Methods: The following tools were employed: Vocabulary and Block Design subtests from the Wechsler Intelligence Scale for Children III, Stroop Test, Modified Card Sorting Test, Controlled Oral Word Association - FAS and Tower of London. Results: Children with BCECTS presented average IQ measure, although their performance was statistically worse when compared to the control group. Children with BCECTS showed significantly lower performance compared to the control group in the following variables: total number of recollected words on the oral fluency test, total number of categories, categorization effect and total number of errors in MCST; and execution time for the Stroop Test Card 1. After controlling for the IQ effect, the total number of errors in the MCST did not show any significant difference between the groups. Discussion: Children with BCECTS showed lower performance in attention and executive functions when compared to healthy children. The results suggest that the concept of ""benign"" BCECTS should be reconsidered.
- Impact of benign childhood epilepsy with centrotemporal spikes (BECTS) on school performance(2012) MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia; REED, Umbertina Conti; GUILHOTO, Laura Maria Figueiredo Ferreira; SERRANO, Virginia Aparecida Gelmeti; GOIS, SolangeBECTS represents the vast majority of childhood focal epilepsy. Owing to the age peculiarity of children who suffer from this disease, i.e., school-going age of between 6 and 9 years, the condition is often referred to as a school disorder by parents and teachers. Objective: The aim of this study was to evaluate the academic performance of children with BED'S, according to the clinical and electroencephalographic ILAE criteria, and compare the results of neuropsychological tests of language and attention to the frequency of epileptic discharges. Methods: The performances of 40 school children with BED'S were evaluated by applying a school performance test (SBT), neuropsychological tests (WISC and Trail-Making), and language tests (Illinois Test Psycholinguistic Abilities - ITPA - and Staggered Spondaic Word - SSW). The same tests were applied in the control group. Results: Children with BED'S, when compared to those in the control group, showed lower scores in academic performance (SPT), digits and similarities subtests of WISC, auditory processing subtest of SSW, and ITPA - representational and automatic level. The study showed that epileptic discharges did not influence the results. Conclusion: Children with BED'S scored significantly lower scores in tests on academic performance, when compared with those in the control group probably due to executive dysfunction.
- Time Interval between First and Last Epileptic Seizures and Electroencephalogram Normalization in Benign Childhood Epilepsy with Centrotemporal Spikes: Influencing Factors(2020) MIZIARA, Carmen Silvia Molleis Galego; MICHELETTO, Maria Laura Jorge; SERRANO, Virginia Aparecida Gelmeti; NAKANISHI, Denise Harumi; SERINOLLI, Mario Ivo; MANREZA, Maria Luiza Giraldes de; REED, Umbertina ContiThe aim of this study was to evaluate the interval between the first and last seizures, the normalization of the electroencephalogram (EEG), and to identify factors of influence. Medical records of children were analyzed with benign childhood epilepsy with centrotemporal spikes. Variables age at first and last seizure, gender, interval between the first and last seizure, the first seizure and EEG normalization, lateralization of the epileptiform discharges, and last epileptic seizure and EEG normalization. The mean time between the first and last seizure was 3.34 years. Early onset of seizures and unilateral discharges were factors that increased the interval between the first and last seizures (p < 0.001). Interval between the last seizure and EEG normalization was 2.40 years, without influence of age (p = 0.986). Interval was shorter in bilateral discharges (p = 0.035). The antiepileptic medicine did not alter the natural history of disease progression. In younger children, the interval between last seizure and normalization of the EEG is reduced compared to older children.
- Sequential motor task (Luria's Fist-Edge-Palm Test) in children with benign focal epilepsy of childhood with centrotemporal spikes(2013) MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia; REED, Umbertina Conti; BUCHPIGUEL, Carlos AlbertoThis study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS) and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT) and School Performance Test (SPT). Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.