FABIO EIJI ARIMURA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Severe Pulmonary Alveolar Proteinosis in a Patient with GATA2 Deficiency(2019) BEDER, T. N.; ALMEIDA, G. Correa de; BERNARDI, F. Del Carlo; SAMANO, M. N.; MINAMOTO, H.; ARIMURA, F. E.; CARVALHO, C. R. R.; VASCONCELOS, D. de Moraes; KAIRALLA, R. A.conferenceObject Routine screening practices for cardiac involvement in patients with sarcoidosis(2019) MOURA, D. M. M.; ARIMURA, F. E. A.; KAIRALLA, R. A. K.; ROCHITTE, C. E. R.; DABARIAN, A. D.; FEITOSA, M. F.; CAFEZEIRO, C. R. F. C.; SOARES, J. S.; RAMIRES, F. J. A. R.; HOTTA, V. T. H.; MADY, C. M.; FERNANDES, F. F.conferenceObject Characterization of Airway Disease in Rheumatoid Arthritis(2019) SABBAG, M. L.; MOLINA, C. de Assis; SAWAMURA, M.; BONFIGLIOLI, K.; ARIMURA, F. E.; ATHANAZIO, R. A.; CARVALHO, C. R. R.; KAIRALLA, R. A.; KAWANO-DOURADO, L.conferenceObject Rheumatoid Arthritis' Clinical Characteristics Stratified by Interstitial Lung Disease Patterns(2019) MOLINA, C. de Assis; SABBAG, M. L.; SAWAMURA, M.; BONFIGLIOLI, K.; ARIMURA, F. E.; CARVALHO, C. R. R.; KAIRALLA, R. A.; KAWANO-DOURADO, L.conferenceObject Interstitial Lung Abnormalities in Rheumatoid Arthritis Patients: Identifying Associated Risk Factors(2019) BONFIGLIOLI, Karina; SAWAMURA, Marcio; NAKAGAWA, Renato; ARIMURA, Fabio; RANGEL, Diana; BUENO, Cleonice; RIBEIRO, Ana Cristina de Medeiros; CARVALHO, Carlos; BONFA, Eloisa; KAIRALLA, Ronaldo; KAWANO-DOURADO, Leticia- Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center(2019) AMARAL, Alexandre Franco; OLIVEIRA, Martina Rodrigues de; DIAS, Olivia Meira; ARIMURA, Fabio Eiji; FREITAS, Carolina Salim Goncalves; ACENCIO, Milena Marques Pagliarelli; ALVARENGA, Vanessa Adelia de; KAIRALLA, Ronaldo Adib; CARVALHO, Carlos Roberto Ribeiro; BALDI, Bruno Guedes; SCLEROSIS, Tuberous; BALBO, Bruno Eduardo Pedroso; WATANABE, Elieser Hitoshi; SAMORANO, Luciana Paula; ONUCHIC, Luiz Fernando; RIVITTI-MACHADO, Maria Cecilia da Matta; MANREZA, Maria Luiza Giraldes de; CORDEIRO, Mauricio Dener; TAKAHASHI, Patricia; OLIVEIRA, Zilda Najjar Prado deIntroductionSerum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement.MethodsWe conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers. Clinical and functional parameters were assessed and correlated with their respective serum VEGF-D levels.ResultsOne hundred and four patients were included in the analysis. Serum VEGF-D levels were higher in LAM patients compared to healthy controls: 796 (404-1588) versus 162 (117-232)pg/mL, respectively (p<0.001). Patients with tuberous sclerosis complex-LAM, TSC-LAM (20%), had higher levels of VEGF-D when compared to patients with sporadic LAM (80%) [1005 (641-2732) vs. 772 (370-1383), p=0.05]. Serum VEGF-D levels were weakly correlated with DLCO (r=-0.26, p=0.001) and lymphatic involvement was more frequent in those with serum VEGF-D levels equal or above 800pg/mL (35% vs. 13%, p=0.02).ConclusionsIn LAM, serum VEGF-D is weakly associated with lung function impairment and strongly associated with lymphatic involvement. VEGF-D is validated for use in Brazilian patients with LAM whose characteristics must be accounted for when evaluating their serum VEGF-D levels.