FABIANA GOULART MARCONDES BRAGA

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: SILVIA MOREIRA AYUB FERREIRA ×

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Agora exibindo 1 - 10 de 14
  • article 4 Citação(ões) na Scopus
    Brazilian Society of Cardiology Guideline on Myocarditis-2022
    (2022) MONTERA, Marcelo Westerlund; MARCONDES-BRAGA, Fabiana G.; SIMOES, Marcus Vinicius; MOURA, Lidia Ana Zytynski; FERNANDES, Fabio; MANGINE, Sandrigo; OLIVEIRA JUNIOR, Amarino Carvalho de; SOUZA, Aurea Lucia Alves de Azevedo Grippa de; IANNI, Barbara Maria; ROCHITTE, Carlos Eduardo; MESQUITA, Claudio Tinoco; AZEVEDO FILHO, Clerio F. de; FREITAS, Dhayn Cassi de Almeida; MELO, Dirceu Thiago Pessoa de; BOCCHI, Edimar Alcides; HOROWITZ, Estela Suzana Kleiman; MESQUITA, Evandro Tinoco; OLIVEIRA, Guilherme H.; VILLACORTA, Humberto; ROSSI NETO, Joao Manoel; BARBOSA, Joao Marcos Bemfica; FIGUEIREDO NETO, Jose Albuquerque de; LUIZ, Louise Freire; HAJJAR, Ludhmila Abrahao; BECK-DA-SILVA, Luis; CAMPOS, Luiz Antonio de Almeida; DANZMANN, Luiz Claudio; BITTENCOURT, Marcelo Imbroise; GARCIA, Marcelo Iorio; AVILA, Monica Samuel; CLAUSELL, Nadine Oliveira; JR, Nilson Araujo de Oliveira; SILVESTRE, Odilson Marcos; SOUZA, Olga Ferreira de; MOURILHE-ROCHA, Ricardo; KALIL FILHO, Roberto; AL-KINDI, Sadeer G.; RASSI, Salvador; ALVES, Silvia Marinho Martins; FERREIRA, Silvia Moreira Ayub; RIZK, Stephanie Itala; MATTOS, Tiago Azevedo Costa; BARZILAI, Vitor; MARTINS, Wolney de Andrade; SCHULTHEISS, Heinz-Peter
  • article 49 Citação(ões) na Scopus
    Mode of Death on Chagas Heart Disease: Comparison with Other Etiologies. A Subanalysis of the REMADHE Prospective Trial
    (2013) AYUB-FERREIRA, Silvia M.; MANGINI, Sandrigo; ISSA, Victor S.; CRUZ, Fatima D.; BACAL, Fernando; GUIMARAES, Guilherme V.; CHIZZOLA, Paulo R.; CONCEICAO-SOUZA, Germano E.; MARCONDES-BRAGA, Fabiana G.; BOCCHI, Edimar A.
    Background: Sudden death has been considered the main cause of death in patients with Chagas heart disease. Nevertheless, this information comes from a period before the introduction of drugs that changed the natural history of heart failure. We sought to study the mode of death of patients with heart failure caused by Chagas heart disease, comparing with non-Chagas cardiomyopathy. Methods and results: We examined the REMADHE trial and grouped patients according to etiology (Chagas vs non-Chagas) and mode of death. The primary end-point was all-cause, heart failure and sudden death mortality; 342 patients were analyzed and 185 (54.1%) died. Death occurred in 56.4% Chagas patients and 53.7% non-Chagas patients. The cumulative incidence of all-cause mortality and heart failure mortality was significantly higher in Chagas patients compared to non-Chagas. There was no difference in the cumulative incidence of sudden death mortality between the two groups. In the Cox regression model, Chagas etiology (HR 2.76; CI 1.34-5.69; p = 0.006), LVEDD (left ventricular end diastolic diameter) (HR 1.07; CI 1.04-1.10; p<0.001), creatinine clearance (HR 0.98; CI 0.97-0.99; p = 0.006) and use of amiodarone (HR 3.05; CI 1.47-6.34; p = 0.003) were independently associated with heart failure mortality. LVEDD (HR 1.04; CI 1.01-1.07; p = 0.005) and use of beta-blocker (HR 0.52; CI 0.34-0.94; p = 0.014) were independently associated with sudden death mortality. Conclusions: In severe Chagas heart disease, progressive heart failure is the most important mode of death. These data challenge the current understanding of Chagas heart disease and may have implications in the selection of treatment choices, considering the mode of death.
  • article 33 Citação(ões) na Scopus
    Impact of Exhaled Breath Acetone in the Prognosis of Patients with Heart Failure with Reduced Ejection Fraction (HFrEF). One Year of Clinical Follow-up
    (2016) MARCONDES-BRAGA, Fabiana G.; BATISTA, Guilherme L.; GUTZ, Ivano G. R.; SALDIVA, Paulo H. N.; MANGINI, Sandrigo; ISSA, Victor S.; AYUB-FERREIRA, Silvia M.; BOCCHI, Edimar A.; PEREIRA, Alexandre Costa; BACAL, Fernando
    Background The identification of new biomarkers of heart failure (HF) could help in its treatment. Previously, our group studied 89 patients with HF and showed that exhaled breath acetone (EBA) is a new noninvasive biomarker of HF diagnosis. However, there is no data about the relevance of EBA as a biomarker of prognosis. Objectives To evaluate whether EBA could give prognostic information in patients with heart failure with reduced ejection fraction (HFrEF). Methods After breath collection and analysis by gas chromatography-mass spectrometry and by spectrophotometry, the 89 patients referred before were followed by one year. Study physicians, blind to the results of cardiac biomarker testing, ascertained vital status of each study participant at 12 months. Results The composite endpoint death and heart transplantation (HT) were observed in 35 patients (39.3%): 29 patients (32.6%) died and 6 (6.7%) were submitted to HT within 12 months after study enrollment. High levels of EBA (>= 3.7 mu g/L, 50th percentile) were associated with a progressively worse prognosis in 12-month follow-up (log-rank = 11.06, p = 0.001). Concentrations of EBA above 3.7 mu g/L increased the risk of death or HT in 3.26 times (HR = 3.26, 95% CI = 1.56-6.80, p = 0.002) within 12 months. In a multivariable cox regression model, the independent predictors of all-cause mortality were systolic blood pressure, respiratory rate and EBA levels. Conclusions High EBA levels could be associated to poor prognosis in HFrEF patients.
  • article 29 Citação(ões) na Scopus
    Hypertonic saline solution for prevention of renal dysfunction in patients with decompensated heart failure
    (2013) ISSA, Victor S.; ANDRADE, Lucia; AYUB-FERREIRA, Silvia M.; BACAL, Fernando; BRAGANCA, Ana C. de; GUIMARAES, Guilherme V.; MARCONDES-BRAGA, Fabiana G.; CRUZ, Fatima D.; CHIZZOLA, Paulo R.; CONCEICAO-SOUZA, Germano E.; VELASCO, Irineu T.; BOCCHI, Edimar A.
    Background: Renal dysfunction is associated with increased mortality in patients with decompensated heart failure. However, interventions targeted to prevention in this setting have been disappointing. We investigated the effects of hypertonic saline solution (HSS) for prevention of renal dysfunction in decompensated heart failure. Methods: In a double-blind randomized trial, patients with decompensated heart failure were assigned to receive three-day course of 100 mL HSS (NaCl 7.5%) twice daily or placebo. Primary end point was an increase in serumcreatinine of 0.3 mg/dL or more. Main secondary end point was change in biomarkers of renal function, including serum levels of creatinine, cystatin C, neutrophil gelatinase-associated lipocalin-NGAL and the urinary excretion of aquaporin 2 (AQP(2)), urea transporter (UT-A(1)), and sodium/hydrogen exchanger 3 (NHE3). Results: Twenty-two patients were assigned to HSS and 12 to placebo. Primary end point occurred in two (10%) patients in HSS group and six (50%) in placebo group (relative risk 0.3; 95% CI 0.09-0.98; P=0.01). Relative to baseline, serum creatinine and cystatin C levels were lower in HSS as compared to placebo (P=0.004 and 0.03, respectively). NGAL level was not statistically different between groups, however the urinary expression of AQP2, UT-A1 and NHE3 was significantly higher in HSS than in placebo. Conclusions: HSS administration attenuated heart failure-induced kidney dysfunction as indicated by improvement in both glomerular and tubular defects, a finding with important clinical implications. HSS modulated the expression of tubular proteins involved in regulation of water and electrolyte homeostasis.
  • conferenceObject
    Use of proliferation signal inhibitors in heart transplantation
    (2013) SAMUEL, M. Avila; BISELLI, B.; ULHOA JUNIOR, M. B.; NUSSBAUM, A. Santos; ESCALANTE, J. P.; MERCONDES-BRAGA, F. G.; AYUB-FERREIRA, S. M.; BRANDAO, S. M.; BACAL, F.; BOCCHI, E. A.
  • article
    Updating of the Brazilian guidelines for chronic heart failure - 2012
    (2012) BOCCHI, Edimar Alcides; MARCONDES-BRAGA, Fabiana Goulart; BACAL, Fernando; FERRAZ, Almir Sergio; ALBUQUERQUE, Denilson; RODRIGUES, Dirceu de Almeida; MESQUITA, Evandro Tinoco; VILAS-BOAS, Fabio; CRUZ, Fatima; RAMIRES, Felix; VILLACORTA JUNIOR, Humberto; SOUZA NETO, Joao David de; ROSSI NETO, Joao Manoel; MOURA, Lidia Zytynski; BECK-DA-SILVA, Luis; MOREIRA, Luiz Felipe; ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; SIMOES, Marcus Vinicius; MOREIRA, Maria da Consolacao; CLAUSELL, Nadine; BESTETTI, Reinaldo; MOURILHE-ROCHA, Ricardo; MANGINI, Sandrigo; RASSI, Salvador; AYUB-FERREIRA, Silvia Moreira; MARTINS, Silvia Marinho; BORDIGNON, Solange; ISSA, Victor Sarli
  • article 156 Citação(ões) na Scopus
    Brazilian Guideline for Chronic and Acute Heart Failure
    (2018) ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; BOCCHI, Edimar Alcides; CLAUSELL, Nadine Oliveira; ALBUQUERQUE, Denilson Campos de; RASSI, Salvador; COLAFRANCESCHI, Alexandre Siciliano; FREITAS JUNIOR, Aguinaldo Figueiredo de; FERRAZ, Almir Sergio; BIOLO, Andreia; BARRETTO, Antonio C. Pereira; RIBEIRO, Antonio Luiz Pinho; POLANCZYK, Carisi Anne; GUALANDRO, Danielle Menosi; ALMEIDA, Dirceu Rodrigues; SILVA, Eneida Rejane Rabelo da; FIGUEIREDO, Estevao Lanna; MESQUITA, Evandro Tinoco; MARCONDES-BRAGA, Fabiana G.; CRUZ, Fatima Das Dores da; RAMIRES, Felix Jose Alvarez; ATIK, Fernando Antibas; BACAL, Fernando; SOUZA, Germano Emilio Conceicao; ALMEIDA JUNIOR, Gustavo Luiz Gouvea de; RIBEIRO, Gustavo Calado de Aguiar; VILLACORTA JUNIOR, Humberto; VIEIRA, Jefferson Luis; SOUZA NETO, Joao David de; ROSSI NETO, Joao Manoel; FIGUEIREDO NETO, Jose Albuquerque de; MOURA, Lidia Ana Zytynsky; GOLDRAICH, Livia Adams; BECK-DA-SILVA, Luis; DANZMANN, Luiz Claudio; CANESIN, Manoel Fernandes; BITTENCOURT, Marcelo Imbroinise; GARCIA, Marcelo Iorio; BONATTO, Marcely Gimenes; SIMOES, Marcus Vinicius; MOREIRA, Maria da Consolacao Vieira; SILVA, Miguel Morita Fernandes da; OLIVERA JUNIOR, Mucio Tavares de; SILVESTRE, Odilson Marcos; SCHWARTZMANN, Pedro Vellosa; BESTETTI, Reinaldo Bulgarelli; ROCHA, Ricardo Mourilhe; SIMOES, Ricardo; PEREIRA, Sabrina Bernardez; MANGINI, Sandrigo; ALVES, Silvia Marinho Martins; FERREIRA, Silvia Moreira Ayub; ISSA, Victor Sarli; BARZILAI, Vitor Salvatore; MARTINS, Wolney de Andrade
  • article
    Brazilian Guideline for Chronic and Acute Heart Failure (vol 111, pg 436, 2018)
    (2019) ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; BOCCHI, Edimar Alcides; CLAUSELL, Nadine Oliveira; ALBUQUERQUE, Denilson Campos de; RASSI, Salvador; COLAFRANCESCHI, Alexandre Siciliano; JUNIOR, Aguinaldo Figueiredo de Freitas; FERRAZ, Almir Sergio; BIOLO, Andreia; BARRETTO, Antonio C. Pereira; RIBEIRO, Antonio Luiz Pinho; POLANCZYK, Carisi Anne; GUALANDRO, Danielle Menosi; ALMEIDA, Dirceu Rodrigues; SILVA, Eneida Rejane Rabelo da; FIGUEIREDO, Estevao Lanna; MESQUITA, Evandro Tinoco; MARCONDES-BRAGA, Fabiana G.; CRUZ, Fatima das Dores da; RAMIRES, Felix Jose Alvarez; ATIK, Fernando Antibas; BACAL, Fernando; SOUZA, Germano Emilio Conceicao; JUNIOR, Gustavo Luiz Gouvea de Almeida; RIBEIRO, Gustavo Calado de Aguiar; JUNIOR, Humberto Villacorta; VIEIRA, Jefferson Luis; FERREIRA, Silvia Moreira Ayub; ISSA, Victor Sarli; NETO, Joao David de Souza; NETO, Joao Manoel Rossi; NETO, Jose Albuquerque de Figueiredo; MOURA, Lidia Ana Zytynsky; GOLDRAICH, Livia Adams; BECK-DASILVA, Luis; DANZMANN, Luiz Claudio; CANESIN, Manoel Fernandes; BITTENCOURT, Marcelo Imbroinise; GARCIA, Marcelo Iorio; BONATTO, Marcely Gimenes; SIMOES, Marcus Vinicius; MOREIRA, Maria da Consolacao Vieira; SILVA, Miguel Morita Fernandes da; JUNIOR, Mucio Tavares de Olivera; SILVESTRE, Odilson Marcos; SCHWARTZMANN, Pedro Vellosa; BESTETTI, Reinaldo Bulgarelli; ROCHA, Ricardo Mourilhe; SIMOES, Ricardo; PEREIRA, Sabrina Bernardez; MANGINI, Sandrigo; ALVES, Silvia Marinho Martins; BARZILAI, Vitor Salvatore; MARTINS, Wolney de Andrade
  • article 13 Citação(ões) na Scopus
    Infectious agents and inflammation in donated hearts and dilated cardiomyopathies related to cardiovascular diseases, Chagas' heart disease, primary and secondary dilated cardiomyopathies
    (2015) MANGINI, Sandrigo; HIGUCHI, Maria de Lourdes; KAWAKAMI, Joyce Tiyeko; REIS, Marcia Martins; IKEGAMI, Renata Nishiyama; PALOMINO, Suely Aparecida Pinheiro; POMERANTZEFF, Pablo Maria Alberto; FIORELLI, Alfredo Inacio; MARCONDES-BRAGA, Fabiana Goulart; BACAL, Fernando; FERREIRA, Silvia Moreira Ayub; ISSA, Victor Sarli; SOUZA, Germano Emilio Conceicao; CHIZZOLA, Paulo Roberto; BOCCHI, Edimar Alcides
    Background: Clinical and experimental conflicting data have questioned the relationship between infectious agents, inflammation and dilated cardiomyopathy (DCM). Objectives: The aim of this study was to determine the frequency of infectious agents and inflammation in endomyocardial biopsy (EMB) specimens from patients with idiopathic DCM, explanted hearts from different etiologies, including Chagas' disease, compared to donated hearts. Methods: From 2008 to 2011, myocardial samples from 29 heart donors and 55 patients with DCMs from different etiologies were studied (32 idiopathic, 9 chagasic, 6 ischemic and 8 other specific etiologies). Inflammation was investigated by immunohistochemistry and infectious agents by immunohistochemistry, molecular biology, in situ hybridization and electron microscopy. Results: There were no differences regarding the presence of macrophages, expression of HLA class II and ICAM-I in donors and DCM. Inflammation in Chagas' disease was predominant. By immunohistochemistry, in donors, there was a higher expression of antigens of enterovirus and Borrelia, hepatitis B and C in DCMs. By molecular biology, in all groups, the positivity was elevated to microorganisms, including co-infections, with a higher positivity to adenovirus and HHV6 in donors towards DCMs. This study was the first to demonstrate the presence of virus in the heart tissue of chagasic DCM. Conclusions: The presence of inflammation and infectious agents is frequent in donated hearts, in the myocardium of patients with idiopathic DCM, myocardial dysfunction related to cardiovascular diseases, and primary and secondary cardiomyopathies, including Chagas' disease. The role of co-infection in Chagas' heart disease physiopathology deserves to be investigated in future studies.
  • article 3 Citação(ões) na Scopus
    Emerging Topics in Heart Failure: Contemporaneous Management of Advanced Heart Failure
    (2020) MARCONDES-BRAGA, Fabiana G.; VIEIRA, Jefferson L.; SOUZA NETO, Joao David de; CALADO, Gustavo; AYUB-FERREIRA, Silvia Moreira; BACAL, Fernando; CLAUSELL, Nadine