FABIANA GOULART MARCONDES BRAGA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- A Comprehensive and Contemporary Review on Immunosuppression Therapy for Heart Transplantation(2020) GOLDRAICH, Livia A.; LEITAO, Santiago A. Tobar; SCOLARI, Fernando L.; MARCONDES-BRAGA, Fabiana G.; BONATTO, Marcely G.; MUNYAL, Dipika; HARRISON, Jennifer; RIBEIRO, Rafaela V. P.; AZEKA, Estela; PIARDI, Diogo; COSTANZO, Maria R.; CLAUSELL, NadineHeart transplantation is the standard of therapy for patients with end-stage heart disease. Since the first human-to-human heart transplantation, performed in 1967, advances in organ donation, surgical techniques, organ preservation, perioperative care, immunologic risk assessment, immunosuppression agents, monitoring of graft function and surveillance of long-term complications have drastically increased recipient survival. However, there are yet many challenges in the modern era of heart transplantation in which immunosuppression may play a key role in further advances in the field. A fine-tuning of immune modulation to prevent graft rejection while avoiding side effects from over immunosuppression has been the vital goal of basic and clinical research. Individualization of drug choices and strategies, taking into account the recipient's clinical characteristics, underlying heart failure diagnosis, immunologic risk and comorbidities seem to be the ideal approaches to improve post-transplant morbidity and survival while preventing both rejection and complications of immunosuppression. The aim of the present review is to provide a practical, comprehensive overview of contemporary immunosuppression in heart transplantation. Clinical evidence for immunosuppressive drugs is reviewed and practical approaches are provided. Cardiac allograft rejection classification and up-to-date management are summarized. Expanding therapies, such as photophoresis, are outlined. Drug-to-drug interactions of immunosuppressive agents focused on cardiovascular medications are summarized. Special situations involving heart transplantation such as sarcoidosis, Chagas diseases and pediatric immunosuppression are also reviewed. The evolution of phamacogenomics to individualize immunosuppressive therapy is described. Finally, future perspectives in the field of immunosuppression in heart transplantation are highlighted.
- Brazilian Guideline for Chronic and Acute Heart Failure(2018) ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; BOCCHI, Edimar Alcides; CLAUSELL, Nadine Oliveira; ALBUQUERQUE, Denilson Campos de; RASSI, Salvador; COLAFRANCESCHI, Alexandre Siciliano; FREITAS JUNIOR, Aguinaldo Figueiredo de; FERRAZ, Almir Sergio; BIOLO, Andreia; BARRETTO, Antonio C. Pereira; RIBEIRO, Antonio Luiz Pinho; POLANCZYK, Carisi Anne; GUALANDRO, Danielle Menosi; ALMEIDA, Dirceu Rodrigues; SILVA, Eneida Rejane Rabelo da; FIGUEIREDO, Estevao Lanna; MESQUITA, Evandro Tinoco; MARCONDES-BRAGA, Fabiana G.; CRUZ, Fatima Das Dores da; RAMIRES, Felix Jose Alvarez; ATIK, Fernando Antibas; BACAL, Fernando; SOUZA, Germano Emilio Conceicao; ALMEIDA JUNIOR, Gustavo Luiz Gouvea de; RIBEIRO, Gustavo Calado de Aguiar; VILLACORTA JUNIOR, Humberto; VIEIRA, Jefferson Luis; SOUZA NETO, Joao David de; ROSSI NETO, Joao Manoel; FIGUEIREDO NETO, Jose Albuquerque de; MOURA, Lidia Ana Zytynsky; GOLDRAICH, Livia Adams; BECK-DA-SILVA, Luis; DANZMANN, Luiz Claudio; CANESIN, Manoel Fernandes; BITTENCOURT, Marcelo Imbroinise; GARCIA, Marcelo Iorio; BONATTO, Marcely Gimenes; SIMOES, Marcus Vinicius; MOREIRA, Maria da Consolacao Vieira; SILVA, Miguel Morita Fernandes da; OLIVERA JUNIOR, Mucio Tavares de; SILVESTRE, Odilson Marcos; SCHWARTZMANN, Pedro Vellosa; BESTETTI, Reinaldo Bulgarelli; ROCHA, Ricardo Mourilhe; SIMOES, Ricardo; PEREIRA, Sabrina Bernardez; MANGINI, Sandrigo; ALVES, Silvia Marinho Martins; FERREIRA, Silvia Moreira Ayub; ISSA, Victor Sarli; BARZILAI, Vitor Salvatore; MARTINS, Wolney de Andrade