MONICA SANCHES YASSUDA
Projetos de Pesquisa
Unidades Organizacionais
EACH, EACH - Docente
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Tackling dementia globally: the Global Dementia Prevention Program (GloDePP) collaboration(2019) CHAN, Kit Yee; ADELOYE, Davies; ASANTE, Kwaku Poku; CALIA, Clara; CAMPBELL, Harry; DANSO, Samuel O.; JUVEKAR, Sanjay; LUZ, Saturnino; MOHAN, Devi; MUNIZ-TERRERA, Graciela; NITRINI, Ricardo; NOROOZIAN, Maryam; NULKAR, Amit; NYAME, Solomon; PARALIKAR, Vasudeo; RODRIGUEZ, Mario A. Parra; POON, Adrienne N.; REIDPATH, Daniel D.; RUDAN, Igor; STEPHAN, Blossom C. M.; SU, TinTin; WANG, Huali; WATERMEYER, Tam; WILKINSON, Heather; YASSUDA, Monica Sanches; YU, Xin; RITCHIE, Craig
- Translation, cross-cultural adaptation and applicability of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS)(2013) LIMA-SILVA, Thais Bento; BAHIA, Valéria Santoro; CARVALHO, Viviane Amaral; GUIMARÃES, Henrique Cerqueira; CARAMELLI, Paulo; BALTHAZAR, Márcio; DAMASCENO, Benito; BOTTINO, Cássio Machado de Campos; BRUCKI, Sônia Maria Dozzi; MIOSHI, Eneida; NITRINI, Ricardo; YASSUDA, Mônica SanchesABSTRACT Background: Staging scales for dementia have been devised for grading Alzheimer's disease (AD) but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD). Objective: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS) to Brazilian Portuguese. Methods: The cross-cultural adaptation process consisted of the following steps: translation, back-translation (prepared by independent translators), discussion with specialists, and development of a final version after minor adjustments. A pilot application was carried out with 12 patients diagnosed with bvFTD and 11 with AD, matched for disease severity (CDR=1.0). The evaluation protocol included: Addenbrooke's Cognitive Examination-Revised (ACE-R), Mini-Mental State Examination (MMSE), Executive Interview (EXIT-25), Neuropsychiatric Inventory (NPI), Frontotemporal Dementia Rating Scale (FTD-FRS) and Clinical Dementia Rating scale (CDR). Results: The Brazilian version of the FTD-FRS seemed appropriate for use in this country. Preliminary results revealed greater levels of disability in bvFTD than in AD patients (bvFTD: 25% mild, 50% moderate and 25% severe; AD: 36.36% mild, 63.64% moderate). It appears that the CDR underrates disease severity in bvFTD since a relevant proportion of patients rated as having mild dementia (CDR=1.0) in fact had moderate or severe levels of disability according to the FTD-FRS. Conclusion: The Brazilian version of the FTD-FRS seems suitable to aid staging and determining disease progression.
- Apathy and functional disability in behavioral variant frontotemporal dementia(2018) YASSUDA, Monica S.; SILVA, Thais B. Lima da; O'CONNOR, Claire M.; MEKALA, Shailaja; ALLADI, Suvarna; BAHIA, Valeria S.; ALMARAL-CARVALHO, Viviane; GUIMARAES, Henrique C.; CARAMELLI, Paulo; BALTHAZAR, Marcio L. F.; DAMASCENO, Benito; BRUCKI, Sonia M. D.; NITRINI, Ricardo; HODGES, John R.; PIGUET, Olivier; MIOSHI, EneidaBackground Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at different levels of overall functional impairment. Methods In a retrospective cross-sectional study, 109 patients with bvFTD from 4 specialist frontotemporal dementia centers (Australia, England, India, and Brazil) were included. The measures administered evaluated everyday function (Disability Assessment for Dementia [DAD]), dementia staging (Clinical Dementia Rating [CDR]), general cognition (Addenbrooke's Cognitive Examination-revised [ACE-R]), and neuropsychiatric symptoms (Neuropsychiatric Inventory [NPI]). Patients were then subdivided according to functional impairment on the DAD into mild, moderate, severe, and very severe subgroups. Three separate multiple linear regression analyses were run, where (1) total DAD, (2) basic activities of daily living (BADL), and (3) instrumental activities of daily living (IADL) scores were dependent variables; ACE-R total score and selected NPI domains (agitation/aggression, euphoria, apathy, disinhibition, irritability, aberrant motor behavior) were used as independent variables. Age, sex, education, and country of origin were controlled for in the analyses. Results Cognitive deficits were similar across the mild, moderate, and severe subgroups but significantly worse in the very severe subgroup. NPI domain scores (agitation/aggression, euphoria, apathy, disinhibition, irritability, aberrant motor behavior) did not differ across the DAD subgroups. In the multiple regression analyses, a model including ACE-R and NPI apathy explained 32.5% of the variance for total DAD scores. For IADL, 35.6% of the variance was explained by the ACE-R only. No model emerged for BADL scores. Conclusions Cognitive deficits and apathy are key contributors to functional disability in bvFTD but factors underlying impairment in BADLs remain unclear. Treatments targeting reduction of disability need to address apathy and cognitive impairment to ensure greater efficacy, especially in regards to IADLs.