MONICA SANCHES YASSUDA
Projetos de Pesquisa
Unidades Organizacionais
EACH, EACH - Docente
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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- Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia(2017) CECCHINI, Mario Amore; YASSUDA, Monica Sanches; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; CARTHERY-GOULART, Maria Teresa; PATROCINIO, Flavia; FOSS, Maria Paula; TUMAS, Vitor; LIMA-SILVA, Thais Bento; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.
- Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease: A 12-Month Follow-Up Study(2021) SILVA, Thais Bento Lima Da; ORDONEZ, Tiago Nascimento; BREGOLA, Allan Gustavo; BAHIA, Valeria Santoro; CECCHINI, Mario Amore; GUIMARAES, Henrique Cerqueira; GAMBOGI, Leandro Boson; CARAMELLI, Paulo; BALTHAZAR, Marcio Luiz Figueredo; DAMASCENO, Benito Pereira; BRUCKI, Sonia Maria Dozzi; SOUZA, Leonardo Cruz de; NITRINI, Ricardo; YASSUDA, Monica SanchesIntroduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores. Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (chi(2)) test and Linear Regression Analysis were used. Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up. Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms.
- Tackling dementia globally: the Global Dementia Prevention Program (GloDePP) collaboration(2019) CHAN, Kit Yee; ADELOYE, Davies; ASANTE, Kwaku Poku; CALIA, Clara; CAMPBELL, Harry; DANSO, Samuel O.; JUVEKAR, Sanjay; LUZ, Saturnino; MOHAN, Devi; MUNIZ-TERRERA, Graciela; NITRINI, Ricardo; NOROOZIAN, Maryam; NULKAR, Amit; NYAME, Solomon; PARALIKAR, Vasudeo; RODRIGUEZ, Mario A. Parra; POON, Adrienne N.; REIDPATH, Daniel D.; RUDAN, Igor; STEPHAN, Blossom C. M.; SU, TinTin; WANG, Huali; WATERMEYER, Tam; WILKINSON, Heather; YASSUDA, Monica Sanches; YU, Xin; RITCHIE, Craig
- Free Recall of Bound Information Held in Short-Term Memory is Unimpaired by Age and Education(2020) YASSUDA, Monica Sanches; CARTHERY-GOULART, Maria Teresa; CECCHINI, Mario Amore; CASSIMIRO, Luciana; FERNANDES, Katarina Duarte; BARADEL, Roberta Roque; GARCIA, Ricardo Basso; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario AlfredoObjectives: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education. The Short-Term Memory Binding (STMB) showed not to be affected by age or education when using the change detection paradigm. However, no previous study has tested the effect of age and education using the free recall paradigm of the STMB. Therefore, the objective of this study was to investigate age and education effects on the free recall version of the STMB test under different memory loads. Methods: 126 healthy volunteers completed the free recall STMB test. The sample was divided into five age bands and into five education bands for comparisons. The STMB test assessed free recall of two (or three) common objects and two (or three) primary colors presented as individual features (unbound) or integrated into unified objects (bound). Results: The binding condition and the larger set size generated lower free recall scores. Performance was lower in older and less educated participants. Critically, neither age nor education modified these effects when compared across experimental conditions (unbound v. bound features). Conclusions: Binding in short-term memory carries a cost in performance. Age and education do not affect such a binding cost within a memory recall paradigm. These findings suggest that this paradigm is a suitable cognitive marker to differentiate healthy brain aging from age-related disease such as AD.
- Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short-term memory binding tests(2020) CECCHINI, Mario Amore; FOSS, Maria Paula; TUMAS, Vitor; PATROCINIO, Flavia A. P.; CHIARI-CORREIA, Rodolfo D.; NOVARETTI, Nathalia; BROZINGA, Tamara R.; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; LIMA-SILVA, Thais Bento; CASSIMIRO, Luciana; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.; YASSUDA, Monica SanchesBackground Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR). Objective To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. Methods Participants were 24 CU, 24 MCI, and 37 ACS. The cognitive scores of the clinical groups were compared using analysis of variance (ANOVA) and receiver-operating characteristic (ROC) analyses were carried out to verify the accuracy of the STMB tasks. Results In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an area under the curve (AUC) of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. Conclusion The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.
- Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum(2021) CECCHINI, Mario Amore; YASSUDA, Monica Sanches; SQUARZONI, Paula; COUTINHO, Artur Martins; FARIA, Daniele de Paula; DURAN, Fabio Luiz de Souza; COSTA, Naomi Antunes da; PORTO, Fabio Henrique de Gobbi; NITRINI, Ricardo; FORLENZA, Orestes Vicente; BRUCKI, Sonia Maria Dozzi; BUCHPIGUEL, Carlos Alberto; PARRA, Mario A.; BUSATTO, Geraldo F.The short-term memory binding (STMB) test involves the ability to hold in memory the integration between surface features, such as shapes and colours. The STMB test has been used to detect Alzheimer's disease (AD) at different stages, from preclinical to dementia, showing promising results. The objective of the present study was to verify whether the STMB test could differentiate patients with distinct biomarker profiles in the AD continuum. The sample comprised 18 cognitively unimpaired (CU) participants, 30 mild cognitive impairment (MCI) and 23 AD patients. All participants underwent positron emission tomography (PET) with Pittsburgh compound B labelled with carbon-11 ([C-11]PIB) assessing amyloid beta (A beta) aggregation (A) and 18fluorine-fluorodeoxyglucose ([F-18]FDG)-PET assessing neurodegeneration (N) (A -N-[n = 35]); A+N-[n = 11]; A+ N+ [n = 19]). Participants who were negative and positive for amyloid deposition were compared in the absence (A-N vs. A+N-) of neurodegeneration. When compared with the RAVLT and SKT memory tests, the STMB was the only cognitive task that differentiated these groups, predicting the group outcome in logistic regression analyses. The STMB test showed to be sensitive to the signs of AD pathology and may represent a cognitive marker within the AD continuum.