ADRIANA BASTOS CONFORTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
bookPart Doença Cerebrovascular(2015) CONFORTO, Adriana Bastos; YAMAMOTO, Fábio Iuji- High resolution vessel wall magnetic resonance imaging in HIV associated vasculopathy(2017) KUBOTA, G. Taricani; FERREIRA, R. de Faria; FIGUEIREDO, T. Rocha; SANTOS, G. Titoneli dos; MORAIS, L. Martins Tavares Scianni; BARBOSA, B. J. Alencar Pires; YAMAMOTO, F. Iuji; GUEDES, B. Fukelmann; CONFORTO, A. Bastos
- The association of post-stroke anhedonia with salivary cortisol levels and stroke lesion in hippocampal/parahippocampal region(2015) TERRONI, Luisa; AMARO JR., Edson; IOSIFESCU, Dan V.; MATTOS, Patricia; YAMAMOTO, Fabio I.; TINONE, Gisela; CONFORTO, Adriana B.; SOBREIRO, Matildes F. M.; GUAJARDO, Valeri D.; LUCIA, Mara Cristina S. De; MOREIRA, Ayrton C.; SCAFF, Milberto; LEITE, Claudia C.; FRAGUAS, RenerioBackground: Anhedonia constitutes a coherent construct, with neural correlates and negative clinical impact, independent of depression. However, little is known about the neural correlates of anhedonia in stroke patients. In this study, we investigated the association of post-stroke anhedonia with salivary cortisol levels and stroke location and volume. Patients and methods: A psychiatrist administered the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition to identify anhedonia in 36 inpatients, without previous depression, consecutively admitted in a neurology clinic in the first month after a first-ever ischemic stroke. Salivary cortisol levels were assessed in the morning, evening, and after a dexamethasone suppression test. We used magnetic resonance imaging and a semi-automated brain morphometry method to assess stroke location, and the MRIcro program according to the Brodmann Map to calculate the lesion volume. Results: Patients with anhedonia had significantly larger diurnal variation (P-value =0.017) and higher morning levels of salivary cortisol (1,671.9 +/- 604.0 ng/dL versus 1,103.9 +/- 821.9 ng/dL; P-value =0.022), and greater stroke lesions in the parahippocampal gyrus (Brodmann area 36) compared to those without anhedonia (10.14 voxels; standard deviation +/- 17.72 versus 0.86 voxels; standard deviation +/- 4.64; P-value =0.027). The volume of lesion in the parahippocampal gyrus (Brodmann area 36) was associated with diurnal variation of salivary cortisol levels (rho=0.845; P-value =0.034) only in anhedonic patients. Conclusion: Our findings suggest that anhedonia in stroke patients is associated with the volume of stroke lesion in the parahippocampal gyrus and with dysfunction of the hypothalamic-pituitary-adrenal axis.
- Impact of Extent of Investigation on Causes of Ischemic Stroke in The Young: A Retrospective Evaluation(2022) CONFORTO, Adriana Bastos; GUERRA, Felipe Borelli Del; FIGUEIREDO, Tamires Rocha; ALMEIDA, Marcele Schettini de; LEITE, Claudia da Costa; YAMAMOTO, Fabio IujiBackground: Despite enormous advances in the diagnosis and treatment of ischemic stroke over the past decades, the extent of ""standard"" investigation to define its causes is heterogeneous. Young patients often undergo a myriad of diagnostic tests in developed countries, but the cost-effectiveness of this approach is uncertain. Objectives: Our main goal was to compare the frequencies of ischemic stroke of undetermined and determined etiologies in young patients with ""complete"" or ""incomplete"" investigation according to either a stepwise or an extensive protocol. Methods: Data from 143 young patients with ischemic stroke were reviewed. For each patient, available data were assessed by means of a stepwise and an extensive protocol of investigation. We compared the frequencies of ischemic stroke of undetermined and determined etiology according to ""complete"" or ""incomplete"" investigation according to each protocol. Results: Completeness of investigation led to a significant increase in determination of stroke etiology when a stepwise approach but not an extensive protocol was applied. Conclusions: These results suggest that ordering an extensive workup to all young patients does not enhance the capability of determining causes of ischemic stroke. Evidence-based guidelines to define pathways of investigation and consensus about the interpretation of tests are deeply needed.
- Extent of investigation and classification criteria impact etiologies of ischemic stroke in the young(2015) CONFORTO, A.; YAMAMOTO, F. I.; FIGUEREDO, T.
- Dural arteriovenous fistula and cerebral venous thrombosis(2015) CONFORTO, Adriana Bastos; NADER, Saulo Nardy; PUGLIA JUNIOR, Paulo; YAMAMOTO, Fabio Iuji; GONÇALVES, Marcia Rubia Rodrigues; VASCONCELOS, Fernando Roberto Gondim C. de; SANTOS, Germana Titoneli dos
- Carotid artery dissection plus subdural hematoma after a roller-coaster ride(2014) ARAUJO, Ana Luza Vieira de; LUCATO, Leandro Tavares; TINONE, Gisela; LEITAO-FILHO, Helio Alberto Pereira; YAMAMOTO, Fabio Iuji; CONFORTO, Adriana Bastos
bookPart Doenças Cerebrovasculares(2016) YAMAMOTO, Fábio Iuji; CONFORTO, Adriana Bastos