ADRIANA BASTOS CONFORTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
8 resultados
Resultados de Busca
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conferenceObject Prodromal transient ischemic attack or minor stroke and outcome in basilar artery occlusion(2014) CONFORTO, A. B.; FREITAS, G. R.; SCHONEWILLE, W. J.; ALGRA, A.- Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine(2014) CONFORTO, Adriana B.; AMARO JR., Edson; GONCALVES, Andre L.; MERCANTE, Juliane P. P.; GUENDLER, Vera Z.; FERREIRA, Josione R.; KIRSCHNER, Clara C. F. B.; PERES, Mario F. P.Background High-frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex (rTMS-DLPFC) is an effective treatment for depression. Preliminary studies indicated beneficial effects of rTMS-DLPFC on pain relief in patients treated for depression, and in patients with chronic migraine. Methods In this randomized, double-blind, parallel-group, single-center, proof-of-principle clinical trial, we tested the hypothesis that 23 sessions of active rTMS-DLPFC delivered over eight weeks would be feasible, safe and superior to sham rTMS to decrease the number of headache days in 18 patients with chronic migraine without severe depression. Per-protocol analysis was performed. Results rTMS-DLPFC applied over eight weeks was feasible and safe in patients with chronic migraine. Contrary to our primary hypothesis, the number of headache days decreased significantly more in the sham group than in the group treated with active rTMS-DLPFC at eight weeks. Average decrease in headache days was >50% in the sham group, indicating a powerful placebo response. Pain intensity improved in both groups to a similar extent. Conclusions Positive results of M1 stimulation in other studies, and the absence of significant benefits of active high-frequency rTMS of the DLPFC in the present study, point to M1 as a more promising target than the DLPFC, for larger trials of noninvasive brain stimulation in patients with chronic migraine.
- Potential impact of point-of-care INR testing on intravenous thrombolysis(2014) CONFORTO, Adriana Bastos
- Translational Neurorehabilitation Research in the Third World What Barriers to Trial Participation Can Teach Us(2014) ANJOS, Sarah M.; COHEN, Leonardo G.; STERR, Annette; ANDRADE, Karina N. F. de; CONFORTO, Adriana B.Background and Purpose Most stroke rehabilitation studies have been performed in high-income countries. The aim of this study was to identify the main barriers for patient inclusion in a research protocol performed in Brazil. MethodsWe evaluated reasons for exclusion of patients in a pilot, randomized, double-blinded clinical trial of stroke rehabilitation. Descriptive statistical analysis was performed. ResultsOnly 5.6% of 571 screened patients were included. Recurrent stroke was responsible for exclusion of 45.4% of potentially eligible patients. ConclusionsRecurrent stroke represented a big barrier to enroll patients in the protocol. External validity of rehabilitation trials will benefit from definition of study criteria according to regional characteristics of patients, including rates of recurrent stroke. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01333579.
- Carotid artery dissection plus subdural hematoma after a roller-coaster ride(2014) ARAUJO, Ana Luza Vieira de; LUCATO, Leandro Tavares; TINONE, Gisela; LEITAO-FILHO, Helio Alberto Pereira; YAMAMOTO, Fabio Iuji; CONFORTO, Adriana Bastos
- Reversible cerebral vasoconstriction syndrome associated with putaminal hemorrhage(2014) KUBOTA, Gabriel T.; MELO, Eduardo S.; BOR-SENG-SHU, Edson; PUGLIA-JUNIOR, Paulo; LUCATO, Leandro T.; CONFORTO, Adriana B.
- Corticospinal Tract Integrity and Lesion Volume Play Different Roles in Chronic Hemiparesis and Its Improvement Through Motor Practice(2014) STERR, Annette; DEAN, Phil J. A.; SZAMEITAT, Andre J.; CONFORTO, Adriana Bastos; SHEN, ShanBackground. Initial evidence suggests that the integrity of the ipsilesional corticospinal tract (CST) after stroke is strongly related to motor function in the chronic state but not the treatment gain induced by motor rehabilitation. Objective. We examined the association of motor status and treatment benefit by testing patients with a wide range of severity of hemiparesis of the left and right upper extremity. Method. Diffusion tensor imaging was performed in 22 patients beyond 12 months after onset of stroke with severe to moderate hemiparesis. Motor function was tested before and after 2 weeks of modified constraint-induced movement therapy. Results. CST integrity, but not lesion volume, correlated with the motor ability measures of the Wolf Motor Function Test and the Motor Activity Log. No differences were found between left and right hemiparesis. Motor performance improved significantly with the treatment regime, and did so equally for patients with left and right arm paresis. However, treatment benefit was not associated with either CST integrity or lesion volume. Conclusion. CST integrity correlated best in this small trial with chronic long-term status but not treatment-induced improvements. The CST may play a different role in the mechanisms mediating long-term outcome compared to those underlying practice-induced gains after a chronic plateau in motor function.
- Magnetic Fields in Noninvasive Brain Stimulation(2014) VIDAL-DOURADO, Marcos; CONFORTO, Adriana Bastos; CABOCLO, Luis Otavio Sales Ferreira; SCAFF, Milberto; GUILHOTO, Laura Maria de Figueiredo Ferreira; YACUBIAN, Elza Marcia TargasThe idea that magnetic fields could be used therapeutically arose 2000 years ago. These therapeutic possibilities were expanded after the discovery of electromagnetic induction by the Englishman Michael Faraday and the American Joseph Henry. In 1896, Arsene d'Arsonval reported his experience with noninvasive brain magnetic stimulation to the scientific French community. In the second half of the 20th century, changing magnetic fields emerged as a noninvasive tool to study the nervous system and to modulate neural function. In 1985, Barker, Jalinous, and Freeston presented transcranial magnetic stimulation, a relatively focal and painless technique. Transcranial magnetic stimulation has been proposed as a clinical neurophysiology tool and as a potential adjuvant treatment for psychiatric and neurologic conditions. This article aims to contextualize the progress of use of magnetic fields in the history of neuroscience and medical sciences, until 1985.