ADRIANA BASTOS CONFORTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Prodromal transient ischemic attack or minor stroke and outcome in basilar artery occlusion(2014) CONFORTO, A. B.; FREITAS, G. R.; SCHONEWILLE, W. J.; ALGRA, A.- Repetitive Transcranial Magnetic Stimulation of the Contralesional Dorsal Premotor Cortex for Upper Extremity Motor Improvement in Severe Stroke: Study Protocol for a Pilot Randomized Clinical Trial(2022) LI, Xin; LIN, Yin-Liang; CUNNINGHAM, David A.; WOLF, Steven L.; SAKAIE, Ken; CONFORTO, Adriana B.; MACHADO, Andre G.; MOHAN, Akhil; O'LAUGHLIN, Kyle; WANG, Xiaofeng; WIDINA, Morgan; PLOW, Ela B.Up to 50% of stroke survivors have persistent, severe upper extremity paresis even after receiving rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) can augment the effects of rehabilitation by modulating corticomotor excitability, but the conventional approach of facilitating excitability of the ipsilesional primary motor cortex (iM1) fails to produce motor improvement in stroke survivors with severe loss of ipsilesional substrate. Instead, the undamaged, contralesional dorsal premotor cortex (cPMd) may be a more suitable target. CPMd can offer alternate, bi-hemispheric and ipsilateral connections in support of paretic limb movement. This pilot, randomized clinical trial seeks to investigate whether rTMS delivered to facilitate cPMd in conjunction with rehabilitation produces greater gains in motor function than conventional rTMS delivered to facilitate iM1 in conjunction with rehabilitation in severely impaired stroke survivors. Twenty- four chronic (>= 6 months) stroke survivors with severe loss of ipsilesional substrate (defined by the absence of physiologic evidence of excitable residual pathways tested using TMS) will be included. Participants will be randomized to receive rTMS to facilitate cPMd or iM1 in conjunction with task-oriented upper limb rehabilitation given for 2 sessions/week for 6 weeks. Assessments of primary outcome related to motor impairment (upper extremity FuglMeyer [UEFM]), motor function, neurophysiology, and functional neuroimaging will be made at baseline and at 6-week end-of-treatment. An additional assessment of motor outcomes will be repeated at 3-month follow-up to evaluate retention. The primary endpoint is 6-week change in UEFM. This pilot trial will provide preliminary evidence on the effects and mechanisms associated with facilitating intact cPMd in chronic severe stroke survivors. The trial is registered on clinicaltrials.gov, NCT03868410. (c) 2022 S. Karger AG, Basel
conferenceObject WHAT BARRIERS FOR A REHABILITATION CLINICAL TRIAL CAN TEACH US ABOUT PROFILES OF PATIENTS WITH STROKE IN A DEVELOPING COUNTRY(2013) CONFORTO, A. B.; ANJOS, S. M.; MELLO, E. A.; FERREIRO, K. N.; NAGAYA, E. M.; MELO, E. S.; REIS, F. I.; COHEN, L. G.conferenceObject Subclinical coronary atherosclerosis in subjects with ischemic stroke caused by cervicocephalic atherothrombosis - preliminary results(2017) ARAUJO, A. L.; NOMURA, C.; SANTOS, R.; SHU, E.; MARTIN, M.; OSHIRO, C.; KOLLNBERGER, K.; MIRANDA, M.; SAMPAIO, G.; LEITE, C.; CONFORTO, A.conferenceObject Effects of low-frequency repetitive magnetic stimulation of the unaffected hemisphere on cortical excitability in the subacute phase after stroke(2013) CONFORTO, A. B.; MELLO, E. A.; ANJOS, S. M.; CONTI, J.; ANDRADE, K. N.; RODRIGUES JR., W.; COHEN, L. G.article Central and peripheral stimulation to enhance effects of motor training in patients with stroke - preliminary results(2015) CONFORTO, A. B.; ANJOS, S. M.; MENEZES, I.; SIQUEIRA, I. L.; MACHADO, A. G.; CONTI, J.; PECKHAM, P. H.; MELLO, E. A.; COHEN, L. G.