ADRIANA BASTOS CONFORTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina - Líder
28 resultados
Resultados de Busca
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conferenceObject Prodromal transient ischemic attack or minor stroke and outcome in basilar artery occlusion(2014) CONFORTO, A. B.; FREITAS, G. R.; SCHONEWILLE, W. J.; ALGRA, A.- Safety of Pregnancy After Cerebral Venous Thrombosis Results of the ISCVT (International Study on Cerebral Vein and Dural Sinus Thrombosis)-2 PREGNANCY Study(2017) SOUSA, Diana Aguiar de; CANHAO, Patricia; CRASSARD, Isabelle; COUTINHO, Jonathan; ARAUZ, Antonio; CONFORTO, Adriana; BEJOT, Yannick; GIROUD, Maurice; FERRO, Jose M.Background and Purpose-Pregnancy is associated with increased risk of venous thrombotic events, including cerebral venous thrombosis. We aimed to study the complications and outcome of subsequent pregnancies in women with previous cerebral venous thrombosis. Methods-Follow-up study of women with acute cerebral venous thrombosis at childbearing age included in a previously described cohort (International Study of Cerebral Vein and Dural Sinus Thrombosis). Patients were interviewed by local neurologists to assess rate of venous thrombotic events, pregnancy outcomes, and antithrombotic prophylaxis during subsequent pregnancies. Results-A total of 119 women were included, with a median follow-up of 14 years. Eighty-two new pregnancies occurred in 47 women. In 83% (68 of 82), some form of antithrombotic prophylaxis was given during at least 1 trimester of pregnancy or puerperium. Venous thrombotic events occurred in 3 pregnancies, including 1 recurrent cerebral venous thrombosis. Two of the 3 women were on prophylactic low-molecular-weight heparin at the time of the event. Outcomes of pregnancies were 51 full-term newborns, 9 preterm births, 2 stillbirths, and 20 abortions (14 spontaneous). Conclusions-In women with prior cerebral venous thrombosis, recurrent venous thrombotic events during subsequent pregnancies are infrequent.
- Quality Of Ischemic Stroke Care Before And After The Covid-19 Pandemic(2022) CONFORTO, Adriana B.
conferenceObject PRESERVATION OF QUALITY OF ACUTE STROKE CARE DURING THE COVID-19 PANDEMIC IN THE LARGEST SOUTH AMERICAN HOSPITAL(2021) ANDRADE, J.; FONSECA, B.; MORAES JR., A. A.; CONFORTO, A.conferenceObject REPETITIVE PERIPHERAL SENSORY STIMULATION AS AN ADD-ON INTERVENTION FOR UPPER LIMB REHABILITATION IN STROKE: A RANDOMIZED TRIAL(2021) CONFORTO, A.; MACHADO, A.; RIBEIRO, N.; PLOW, E.; LIEW, S-L; LEITE, C. Da Costa; ZAVALIANGOS-PETROPULU, A.; MENEZES, I.; ANJOS, S. Dos; LUCCAS, R.; PECKHAM, P.; COHEN, L.conferenceObject NEUROMODULATION IN ACUTE ISCHEMIC STROKE: A SYSTEMATIC REVIEW AND META-ANALYSIS(2021) PELLEGRINO, M.; SALLES, I.; SHINOSAKI, J.; REIS, S.; NOGUEIRA, R.; CONFORTO, A.- Repetitive Transcranial Magnetic Stimulation of the Contralesional Dorsal Premotor Cortex for Upper Extremity Motor Improvement in Severe Stroke: Study Protocol for a Pilot Randomized Clinical Trial(2022) LI, Xin; LIN, Yin-Liang; CUNNINGHAM, David A.; WOLF, Steven L.; SAKAIE, Ken; CONFORTO, Adriana B.; MACHADO, Andre G.; MOHAN, Akhil; O'LAUGHLIN, Kyle; WANG, Xiaofeng; WIDINA, Morgan; PLOW, Ela B.Up to 50% of stroke survivors have persistent, severe upper extremity paresis even after receiving rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) can augment the effects of rehabilitation by modulating corticomotor excitability, but the conventional approach of facilitating excitability of the ipsilesional primary motor cortex (iM1) fails to produce motor improvement in stroke survivors with severe loss of ipsilesional substrate. Instead, the undamaged, contralesional dorsal premotor cortex (cPMd) may be a more suitable target. CPMd can offer alternate, bi-hemispheric and ipsilateral connections in support of paretic limb movement. This pilot, randomized clinical trial seeks to investigate whether rTMS delivered to facilitate cPMd in conjunction with rehabilitation produces greater gains in motor function than conventional rTMS delivered to facilitate iM1 in conjunction with rehabilitation in severely impaired stroke survivors. Twenty- four chronic (>= 6 months) stroke survivors with severe loss of ipsilesional substrate (defined by the absence of physiologic evidence of excitable residual pathways tested using TMS) will be included. Participants will be randomized to receive rTMS to facilitate cPMd or iM1 in conjunction with task-oriented upper limb rehabilitation given for 2 sessions/week for 6 weeks. Assessments of primary outcome related to motor impairment (upper extremity FuglMeyer [UEFM]), motor function, neurophysiology, and functional neuroimaging will be made at baseline and at 6-week end-of-treatment. An additional assessment of motor outcomes will be repeated at 3-month follow-up to evaluate retention. The primary endpoint is 6-week change in UEFM. This pilot trial will provide preliminary evidence on the effects and mechanisms associated with facilitating intact cPMd in chronic severe stroke survivors. The trial is registered on clinicaltrials.gov, NCT03868410. (c) 2022 S. Karger AG, Basel
- White Matter Integrity and Chronic Poststroke Upper Limb Function: An ENIGMA Stroke Recovery Analysis(2023) DOMIN, Martin; HORDACRE, Brenton; HOK, Pavel; BOYD, Lara A.; CONFORTO, Adriana B.; ANDRUSHKO, Justin W.; BORICH, Michael R.; CRADDOCK, Richard C.; DONNELLY, Miranda R.; DULA, Adrienne N.; WARACH, Steven J.; KAUTZ, Steven A.; LO, Bethany P.; SCHRANZ, Christian; SEO, Na Jin; SRIVASTAVA, Shraddha; WONG, Kristin A.; ZAVALIANGOS-PETROPULU, Artemis; THOMPSON, Paul M.; LIEW, Sook-Lei; LOTZE, MartinBACKGROUND:Integrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant for compensation or recovery of function.METHODS:We used the ENIGMA Stroke Recovery data set, a multicenter, retrospective, and cross-sectional collection of patients with upper limb impairment during the chronic phase of stroke to test the relevance of tracts in individuals with less and more severe (laterality index of CST fractional anisotropy & GE;0.25) CST damage in an observational study design. White matter integrity was quantified using fractional anisotropy for the CST, the superior longitudinal fascicle, and the callosal fibers interconnecting the primary motor cortices between hemispheres. Optic radiations served as a control tract as they have no a priori relevance for the motor system. Pearson correlation was used for testing correlation with upper limb motor function (Fugl-Meyer upper extremity).RESULTS:From 1235 available data sets, 166 were selected (by imaging, Fugl-Meyer upper extremity, covariates, stroke location, and stage) for analyses. Only individuals with severe CST damage showed a positive association of fractional anisotropy in both callosal fibers interconnecting the primary motor cortices (r[21]=0.49; P=0.025) and superior longitudinal fascicle (r[21]=0.51; P=0.018) with Fugl-Meyer upper extremity.CONCLUSIONS:Our data support the notion that individuals with more severe damage of the CST depend on residual pathways for achieving better upper limb outcome than those with less affected CST.
conferenceObject WHAT BARRIERS FOR A REHABILITATION CLINICAL TRIAL CAN TEACH US ABOUT PROFILES OF PATIENTS WITH STROKE IN A DEVELOPING COUNTRY(2013) CONFORTO, A. B.; ANJOS, S. M.; MELLO, E. A.; FERREIRO, K. N.; NAGAYA, E. M.; MELO, E. S.; REIS, F. I.; COHEN, L. G.conferenceObject Repetitive Peripheral Sensory Stimulation in Stroke: a Systematic Review and Meta-Analysis(2018) CONFORTO, Adriana B.; ANJOS, Sarah; SILVA, Arnaldo; CONTI, Juliana; MACHADO, Andre G.; COHEN, Leonardo G.
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