MERCIA PATRICIA FERREIRA CONCEICAO
Projetos de Pesquisa
Unidades Organizacionais
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
1 resultados
Resultados de Busca
Agora exibindo 1 - 1 de 1
- Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer(2020) MANGONE, Flavia R.; VALOYES, Maira A. V.; NASCIMENTO, Renan G. do; CONCEICAO, Mercia P. F.; BASTOS, Daniel R.; PAVANELLI, Ana C.; SOARES, Ibere C.; MELLO, Evandro S. de; NONOGAKI, Suely; OSORIO, Cynthia A. B.; NAGAI, Maria A.Aim: The PHLDA (pleckstrin homology like domain, family A) gene family encodes proteins capable of inhibiting AKT (serine/threonine kinase) signaling through phosphoinositol binding competition. Results & methodology: Using in silico analysis, we found that Luminal A and B patients' short relapse-free survival was associated with low PHLDA1 or PHLDA3 and high PHLDA2 expression. In a cohort of 393 patients with luminal breast cancer evaluated by immunohistochemistry on tissue microarrays, we found a direct association of PHLDA3 expression with hormonal therapy response (p = 0.013). Conclusion: Our findings provide new information on the role played by the PHLDA family members as prognostic markers in breast cancer, and more importantly, we provide evidence that they might also predict a response to endocrine therapy.