LEONARDO ALFONSO BUSTAMANTE LOPEZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
conferenceObject EFFICACY OF TRIDIMENSIONAL ENDORECTAL ULTRASOUND IN COMPARISON TO HISTOPATHOLOGY FOR EVALUATION EXTRA PERITONEAL RECTAL NEOPLASMS.(2015) PINTO, R.; CORREA NETO, I.; NAHAS, S.; NAHAS, C.; MARQUES, C.; RIBEIRO JUNIOR, U.; BUSTAMANTE-LOPEZ, L.; SOARES, D.; CECCONELLO, I.- Gastrointestinal stromal tumor of the rectum treated with neoadjuvant Imatinib followed by transanal endoscopic microsurgery(2015) NAHAS, Caio Sergio Rizkallah; NAHAS, Sergio Carlos; MARQUES, Carlos Frederico Sparapan; SCHMERLING, Rafael; BUSTAMANTE-LOPEZ, Leonardo Alfonso; RIBEIRO JUNIOR, Ulysses; CECCONELLO, Ivan
- Role of radiation in rectal cancers(2015) HABR-GAMA, A.; JORGE, J. M. N.; BUSTAMANTE-LOPEZ, L. A.The management of rectal cancer has dramatically improved during the last two decades and therapeutic decisions should now be individualized and based on a multidisciplinary approach, involving radiation oncologists, medical oncologists, diagnostic radiologists, surgeons, pathologists, and primary care physicians. The benefits of preoperative chemoradiotherapy include downsizing, downstaging, improved sphincter-preservation rates, and reduced local recurrence. In addition, complete pathological response is possible in a significant percentage of patients. The combination of neoadjuvant radiotherapy and total mesorectal excision may result in significant long-term adverse effects, including sexual and anorectal sphincter dysfunction. This should be taken into account during selection of patients for radiotherapy. In addition, ongoing trials are addressing quality of life issues with modern radiation techniques and newer chemotherapeutic agents. © Springer Science+Business Media, LLC 2015.
conferenceObject ENDOSCOPIC ASSISTED COLOSTOMY WITH PERCUTANEOUS COLOPEXY: AN EXPERIMENTAL STUDY.(2015) BUSTAMANTE-LOPEZ, L.; SULBARAN, M.; SAKAI, P.; MOURA, E.; NAHAS, C.; MARQUES, C.; SAKAI, C.; CECCONELLO, I.; PINTO, R.; NAHAS, S.- Effects of radiation therapy for rectal cancer on anorectal function(2015) JORGE, J. M. N.; HABR-GAMA, A.; BUSTAMANTE-LOPEZ, L. A.Regardless of whether adjuvant or neoadjuvant radiotherapy is used, pelvic irradiation adversely affects anorectal function. Although survival remains the primary goal in treatment, maintaining adequate anal continence is necessary for good quality of life. Radiation damages to the internal anal sphincter and the myenteric cells are frequently seen. Other mechanisms of continence affected by radiotherapy include decreased stool consistency, impaired rectal capacity, and decreased anorectal sensation. These adverse effects are associated with an increasing indication of sphincter-preserving operations, and demand for improved radiation techniques and more favorable postoperative functional results. Symptoms of urgency and fecal incontinence are common after anterior resection with or without neoadjuvant chemoradiotherapy, but generally resolve within the first 2 years after surgery. In patients with persistent symptoms of fecal incontinence, conservative therapy including biofeedback should be offered. © Springer Science+Business Media, LLC 2015.
conferenceObject DO MORBID OBESE PATIENTS HAVE MORE CLINICAL AND MANOMETRIC PLEVIC FLOOR ABNORMALITIES IN COMPARISON TO NONOBESE PATIENTS? RESULTS OF A CASE-MATCHED STUDY(2015) CORREA NETO, I.; PINTO, R.; NAHAS, S.; JORGE, J.; BUSTAMANTE-LOPEZ, L.; NAHAS, C.; MARQUES, C. Sparapan; CECCONELLO, I.- Prognostic factors of surgically-treated patients with cancer of the right colon: a ten years' experience of a single universitary institution(2015) NAHAS, Sergio Carlos; NAHAS, Caio Sergio Rizkallah; BUSTAMANTE-LOPEZ, Leonardo Alfonso; PINTO, Rodrigo Ambar; MARQUES, Carlos Frederico Sparapan; CAMPOS, Fabio Guilherme; CECONELLO, IvanBACKGROUND: Colorectal cancer is one of the most common malignancies in the world. There are many controversies in the literature about the prognostic value of primary tumor location. Many studies have shown higher survival rates for tumors in the right colon, and worse prognosis for lesions located more distally in the colon. AIM: To analyze the results of surgical treatment of right-sided colon cancers patients operated in one decade period and identify the prognostic factors that were associated with lower overall survival in stages I-IV patients. METHODS: A retrospective review from the prospectively collected database identified 178 patients with right-sided colon cancer surgically treated with curative intent. Demographic factors (gender and age), tumor factors (site, T stage, N stage, M stage, histological type and tumor differentiation), and lymph node yield were extracted to identify those associated with lower overall survival. RESULTS: Mean age was 65 (±12) years old, and 105 (56.1%) patients were female. Most common affected site was ascending colon (48.1%), followed by cecum (41.7%) and hepatic flexure (10.2%). Mean length of hospital stay was 14 (±2.8) days. T stage distribution was T1 (4.8%), T2 (7.5%), T3 (74.9%), and T4 (12.8%). Nodal involvement was present in 46.0%, and metastatic disease in 3.7%. Twelve or more lymph nodes were obtained in 87.2% of surgical specimens and 84.5% were non-mucinous tumors. Mean survival time was 38.3 (±30.8) months. Overall survival was affected by T stage, N stage, M stage, and final stage. Lymph node involvement (OR=2.06) and stage III/IV (OR=2.81) were independent negative prognostic factors. CONCLUSION: Right-sided colon cancer presented commonly at advanced stage. Advanced stage and lymph node involvement were factors associated with poor long term survival.