ALICIA MATIJASEVICH MANITTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis(2015) CASTILLO-LAURA, Helen; SANTOS, Ina S.; QUADROS, Lenice C. M.; MATIJASEVICH, AliciaThis study reviewed the evidence that assessed the association between maternal pre-pregnancy body mass index (BMI) and/or gestational weight gain and offspring body composition in childhood. A systematic review was conducted. Cohort studies, case-control studies and randomized controlled trials measuring offspring body composition by indirect methods were included. Meta-analyses of the effect of pre-pregnancy BMI on offspring fat-free mass, body fat percent, and fat mass were conducted through random-effects models. 20 studies were included, most of which reported a positive association of pre-pregnancy BMI with offspring body fat. Standardized mean differences in body fat percent, fat mass and fat-free mass between infants of women with normal pre-pregnancy BMI and those of overweight/obese women were 0.31 percent points (95% CI: 0.19; 0.42), 0.38kg (95% CI: 0.26; 0.50), and 0.18kg (95% CI: -0.07; 0.42), respectively. Evidence so far suggests that pre-pregnancy maternal overweight is associated with higher offspring adiposity.
- Attention-Deficit/Hyperactivity Disorder and Very Preterm/Very Low Birth Weight: A Meta-analysis(2018) FRANZ, Adelar Pedro; BOLAT, Gul Unsel; BOLAT, Hilmi; MATIJASEVICH, Alicia; SANTOS, Ina Silva; SILVEIRA, Rita C.; PROCIANOY, Renato Soibelmann; ROHDE, Luis Augusto; MOREIRA-MAIA, Carlos RenatoCONTEXT: Although very preterm (VP), extremely preterm (EP), very low birth weight (VLBW), and extremely low birth weight (ELBW) newborns seem to have a higher risk of later attention-deficit/hyperactivity disorder (ADHD), the magnitude of the risk is not well-defined. OBJECTIVE: To systematically review and meta-analyze the risk of VP/VLBW and EP/ELBW individuals to develop a ADHD categorical diagnosis or dimensional symptomatology compared with controls with normal weight and/or birth age. DATA SOURCES: We used PsycINFO, Medline, Embase, and Cochrane databases. STUDY SELECTION: We selected cross-sectional, prospective, or retrospective studies with no time or language restriction. DATA EXTRACTION: Independent reviewers screened and extracted data using predefined standard procedures. RESULTS: In 12 studies (N = 1787), researchers relying on a categorical diagnosis showed that both VP/VLBW and EP/ELBW subjects have a higher ADHD risk (odds ratio [OR] = 3.04 higher than controls; 95% confidence interval [CI] 2.19 to 4.21). In subgroup analyses, we demonstrated that the more extreme the cases, the higher the ORs (VP/VLBW: OR = 2.25 [95% CI 1.56 to 3.26]; EP/ELBW: OR = 4.05 [95% CI 2.38 to 6.87]). We drew data from 29 studies (N = 3504) on ADHD symptomatology and found significant associations with inattention (standardized mean difference [SMD] = 1.31, 95% CI 0.66 to 1.96), hyperactivity and impulsivity (SMD = 0.74, 95% CI 0.35 to 1.13), and combined symptoms (SMD = 0.55, 95% CI 0.42 to 0.68) when compared with controls. LIMITATIONS: Heterogeneity was significantly high for all analyses involving the 3 ADHD dimensions. CONCLUSIONS: With our results, we provide evidence that VP/VLBW subjects have an increased risk of ADHD diagnosis and symptomatology compared with controls, and these findings are even stronger in the EP/ELBW group. Future researchers should address which risk factors related to prematurity or low birth weight lead to ADHD.
- The impact of cash transfers on mental health in children and young people in low-income and middle-income countries: a systematic review and meta-analysis(2021) ZIMMERMAN, Annie; GARMAN, Emily; AVENDANO-PABON, Mauricio; ARAYA, Ricardo; EVANS-LACKO, Sara; MCDAID, David; PARK, A-La; HESSEL, Philipp; DIAZ, Yadira; MATIJASEVICH, Alicia; ZIEBOLD, Carola; BAUER, Annette; PAULA, Cristiane Silvestre; LUND, CrickIntroduction Although cash transfer programmes are not explicitly designed to improve mental health, by reducing poverty and improving the life chances of children and young people, they may also improve their mental health. This systematic review and meta-analysis assessed the evidence on the effectiveness of cash transfers to improve the mental health of children and young people in low-income and middle-income countries. Methods We searched Pubmed, EBSCOhost, Scientific Electronic Library Online, ISI Web of Science and Social Sciences Citation Index and grey literature (from January 2000 to July 2020) for studies which quantitatively assessed the impact of cash transfers on mental health in young people (aged 0-24 years), using a design that incorporated a control group. We extracted Cohen's d effects size and used a random-effects model for the meta-analysis on studies that measured depressive symptoms, I-2 statistic and assessment of study quality. Results We identified 12 116 articles for screening, of which 12 were included in the systematic review (covering 13 interventions) and seven in the meta-analysis assessing impact on depressive symptoms specifically. There was high heterogeneity (I-2=95.2) and a high risk of bias (0.38, 95% CIs: -5.08 to 5.85; p=0.86) across studies. Eleven interventions (85%) showed a significant positive impact of cash transfers on at least one mental health outcome in children and young people. However, no study found a positive effect on all mental health outcomes examined, and the meta-analysis showed no impact of cash transfers on depressive symptoms (0.02, 95% CIs: -0.19 to 0.23; p=0.85). Conclusion Cash transfers may have positive effects on some mental health outcomes for young people, with no negative effects identified. However, there is high heterogeneity across studies, with some interventions showing no effects. Our review highlights how the effect of cash transfers may vary by social and economic context, culture, design, conditionality and mental health outcome.
- Fear for the future: Eco-anxiety and health implications, a systematic review(2022) BOLUDA-VERDU, Inmaculada; SENENT-VALERO, Marina; CASAS-ESCOLANO, Mariola; MATIJASEVICH, Alicia; PASTOR-VALERO, MariaBackground: Although there is no standard definition for eco-anxiety, most authors define it as people's emotional reaction of concern, worry, anxiety, and fear in view of global Climate Change (CC) threats and concurrent environmental degradation. This systematic review was carried out to critically evaluate the evidence on eco-anxiety related to CC and its health implications in general populations. Methods: We performed a search for scientific articles in PubMed, Scopus, Embase, Web of Science, and Cochrane Central. Studies were included if they complied with the study objective. Selection of articles and data extraction were carried out independently by 2 reviewers. We used the Axis tool and JBI critical appraisal checklist to assess the quality of the studies. Results: A final sample of 12 articles was included in this review. The methodological quality of the studies was limited. A wide variety of eco-anxiety definitions was used in the different studies but further research is needed to provide conceptual clarity of the term eco-anxiety. Eco-anxiety was associated with functional impairment, symptoms of depression, anxiety, PTSD, stress and insomnia, lower self-rated mental health, and reluctance to have children. Moreover, habitual worry about global warming was associated with a pro-ecological worldview, a green self-identity and pro-environmental behavior, strongly suggesting a constructive nature. Indeed, pro -environmental behavior in the form of climate activism would buffer the impact of CCA cognitive-emotional impairment on MDD symptoms. However, sometimes engaging in pro-environmental behavior might not be successful in dealing with eco-anxiety, since individuals might perceive that their efforts do not help to mitigate the CC crisis. Conclusions: Results have to be interpreted with caution since the methodological quality of the studies was limited. However, they do suggest a link between eco-anxiety and negative mental health outcomes, mainly in younger generations, women, and poorer countries in the ""Global South"". Eco-anxiety may constitute a stressor to mental health, particularly if coping mechanisms are not successfully developed.
- Brazilian cohorts with potential for life-course studies: a scoping review(2020) ARAUJO, Waleska Regina Machado; SANTOS, Ina S.; MENEZES FILHO, Naercio Aquino; SOUZA, Maria Thereza Costa Coelho de; CUNHA, Antonio Jose Ledo Alves da; MATIJASEVICH, AliciaOBJECTIVE: To identify the Brazilian cohorts that started either in the prenatal period or at birth, to describe their characteristics and the explored variables, and to map the cohorts with potential for studies on early determinants on health and the risk of falling ill on later stages of the life cycle. METHODS: A scoping review was carried out. The articles were searched in the electronic databases PubMed and Virtual Health Library (VHL). The descriptors used were [(((""Child"" OR ""Child, Preschool'' OR ""Infant'' OR ""Infant, Newborn"") AND (Cohort Studies"" OR ""Longitudinal Studies"")) AND ""Brazil"")]. The inclusion criteria were Brazilian cohorts that started the baseline in the prenatal period or at birth and with at least two follow-ups with the participants. In order to meet the concept of LCE, we excluded those cohorts whose follow-ups were restricted to the first year of life, as well as those that did not address biological, behavioral and psychosocial aspects, and cohorts with data collection of a single stage of the life cycle. RESULTS: The search step identified 5,010 articles. Eighteen cohorts were selected for descriptive synthesis. The median number of baseline participants was 2,000 individuals and the median age at the last follow-up was 9 years. Sample loss at the last follow-up ranged from 9.2 to 87.5%. Most cohorts monitored two phases of the life cycle (the perinatal period and childhood). The Southern region had the highest number of cohorts. The main variables collected were sociodemographic and environmental aspects of the family, morbidity aspects, nutritional practices and lifestyle. CONCLUSIONS: We recommend the continuity of these cohorts, the approach to different social contexts and the performance of follow-ups with participants in different phases of the life cycle for the strengthening and expansion of life course epidemiology analyses in Brazil.
- Factors associated with risk behaviors in adolescence: a systematic review(2021) BOZZINI, Ana Beatriz; BAUER, Andreas; MARUYAMA, Jessica; SIMOES, Ricardo; MATIJASEVICH, AliciaObjective: Understanding the distal (p 6 years of age) and proximal (<= 6 years of age and early adolescence) factors in adolescent risk behavior is important for preventing and reducing morbidity and mortality in this population. This study sought to investigate the factors associated with the following adolescent risk behaviors: i) aggressiveness and violence, ii) tobacco, alcohol, and illicit substance use, iii) depressive behavior and self-harm (including suicidal ideation and attempts), iv) sexual risk behavior, and v) multiple risk behavior. Methods: A systematic review was conducted to identify longitudinal studies that examined factors associated with adolescent risk behaviors. The PubMed, PsycINFO, and LILACS databases were searched. Results: Of the 249 included studies, 23% reported distal risk factors, while the remaining reported proximal risk factors. Risk factors were related to sociodemographic characteristics (neighborhood, school, and peers), family patterns, and the presence of other adolescent risk behaviors. Conclusion: Distal and proximal factors in adolescent risk behavior that are not exclusively socioeconomic, familial, environmental, or social should be explored more thoroughly.
- Epidemiology of functional gastrointestinal disorders in children and adolescents: A systematic review(2017) BORONAT, Alexandre Canon; FERREIRA-MAIA, Ana Paula; MATIJASEVICH, Alicia; WANG, Yuan-PangAIM To assess the prevalence of functional gastrointestinal disorders (FGIDs) in children and adolescents. METHODS PubMed, EMBASE, and Scopus databases were searched for original articles from inception to September 2016. The literature search was made in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. For inclusion, each study had to report epidemiological data on FGIDs in children between 4 and 18 years old and contain standardized outcome based on Rome.,. or. criteria. The overall quality of included epidemiological studies was evaluated in accordance with Loney's proposal for prevalence studies of health literature. Two reviewers assessed each study for data inclusion and extraction. Discrepancies were reconciled through discussion with seniors. RESULTS A total of 659 articles were identified from the databases and 16 through manual search. A total of 43 articles fulfilled the eligibility criteria for full-text reading, with 26 remaining to be included in the final analysis. All studies were written in English and published between 2005 and 2016. Eight (30.8%) articles were performed in North America, five (19.2%) in Latin America, five (19.2%) in Europe, seven (27%) in Asia, and one (3.8%) in Africa. Sample size varied between 114 and 99416 subjects, totaling 132600 individuals. Fourteen (53.9%) studies recruited their target samples from schools, 11 (42.3%) from health-care settings and the remaining one (3.8%) from online panel community. The overall FGID prevalence rates for student samples ranged from 9.9% to 29% to as high as 87% in clinical samples. Cyclic vomiting, irritable bowel syndrome and functional constipation were the most researched conditions, with a prevalence ranging from 0.2% to 6.2%, 0% to 45.1% and 0.5% to 86.9%, respectively. The qualitative appraisal revealed that most of the studies showed average or below average generalizability. CONCLUSION The heterogeneity of the studies on FGIDs must be improved in order to allow comparison. Improvements should include appropriate sampling of representative population, comparable study setting, and consistent data collection.
- Breastfeeding and the Development of Socio-Emotional Competencies: A Systematic Review(2019) TURNER, Samantha; MARUYAMA, Jessica Mayumi; MATIJASEVICH, Alicia; PASTOR-VALERO, MariaAim: To assess the current scientific evidence about the relationship between breastfeeding and the development of infant's socio-emotional competencies. Materials and Methods: A systematic review of literature was conducted through PubMed, LILACS (Literatura Latinoamericana y del Caribe en Ciencias de la Salud), and PsycINFO of population-based cohorts. Records were screened, data extracted, and a quality assessment performed by two authors independently. Results: Thirteen studies were included in the review with six finding a statistically significant association between breastfeeding and the development of socio-emotional competencies such as problem solving, agreeableness, and optimism. In five studies, no statistically significant association was found, and in three, a negative association existed. Regarding quality assessment, four studies had a strong global rating, four had a moderate rating, and five had a weak global rating. Conclusion: Almost half (6/13) of the studies found a positive association between breastfeeding and the development of social-emotional competencies in infants; however, a great heterogeneity was present in the quality of the included studies. There is a need for further and higher quality research into this field of study.