FERNANDO GODINHO ZAMPIERI
Projetos de Pesquisa
Unidades Organizacionais
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Fluid balance and central venous pressure in sepsis: Small pieces in an enormous puzzle(2011) ZAMPIERI, Fernando Godinho; PARK, Marcelo; AZEVEDO, Luciano Cesar Pontes
- Acute treatment of uncompensated heart failure with 10% hypertonic saline and its subsequent effect on respiratory patterns(2011) ZAMPIERI, Fernando Godinho; CARUSO, Pedro
- Sepsis-associated encephalopathy: not just delirium(2011) ZAMPIERI, Fernando Godinho; PARK, Marcelo; MACHADO, Fabio Santana; AZEVEDO, Luciano Cesar PontesSepsis is a major cause of mortality and morbidity in intensive care units. Organ dysfunction is triggered by inflammatory insults and tissue hypoperfusion. The brain plays a pivotal role in sepsis, acting as both a mediator of the immune response and a target for the pathologic process. The measurement of brain dysfunction is difficult because there are no specific biomarkers of neuronal injury, and bedside evaluation of cognitive performance is difficult in an intensive care unit. Although sepsis-associated encephalopathy was described decades ago, it has only recently been subjected to scientific scrutiny and is not yet completely understood. The pathophysiology of sepsis-associated encephalopathy involves direct cellular damage to the brain, mitochondrial and endothelial dysfunction and disturbances in neurotransmission. This review describes the most recent findings in the pathophysiology, diagnosis, and management of sepsis-associated encephalopathy and focuses on its many presentations.