MARIANA FURIERI GUZZO
Projetos de Pesquisa
Unidades Organizacionais
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Congenital Hypopituitarism: Stem Cell Accumulation in Mutants with Developmental Arrest and Depletion in Mutants with Hyperplasia(2014) CHANG, Claudia Veiga; ARAUJO, Ricardo Viera; CIRQUEIRA, Cinthya Santos; PARFIENIUK, Agata; GUZZO, Mariana F.; BENEDETTI, Anna Flavia F.; SOARES, Ibere C.; MILLAN, Maria Ines Perez; CAMPER, Sally Ann; CARVALHO, Luciani R. S.conferenceObject The Inhibitory Effects of Ketoconazole in Immortalized Pituitary Cell Lines Leading to Decreased Cell Viability Are Due to an Increase of Apoptosis Markers and Cell Cycle Inhibitors(2014) GUZZO, Mariana F.; CARVALHO, Luciani R. S.; BRONSTEIN, Marcello D.- Apoptosis: its role in pituitary development and neoplastic pituitary tissue(2014) GUZZO, M. F.; CARVALHO, L. R. S.; BRONSTEIN, M. D.Apoptosis, also known as programmed cell death, is a phenomenon in which different stimuli trigger cellular mechanisms that culminate in death, in the absence of inflammatory cell response. Two different activation pathways are known, the intrinsic pathway (or mitochondrial) and extrinsic (or death-receptor pathway), both pathways trigger enzymatic reactions that lead cells to break up and be phagocytized by neighboring cells. This process is a common occurrence in physiological and pathological states, participating in the control of cell proliferation, differentiation and remodeling of organs. In the early steps of pituitary gland formation, numerous apoptotic cells are detected in the separation of Rathke's pouch from the roof of oral ectoderm. In the distal part of the gland, which will form the adenohypophysis, the ratio of apoptosis was significantly lower. However, there is evidence that neoplastic pituitary cells undergo unbalance in genes that control apoptosis leading to uncontrolled cell growth. No direct evidence of apoptosis was found in the drugs used for tumors producing prolactin and growth hormone. In conclusion, an unbalancing in the apoptosis process is the boundary between development and tumor growth.
conferenceObject Congenital Hypopituitarism: Stem Cell Accumulation in Mutants with Developmental Arrest and Depletion in Mutants with Hyperplasia(2014) CHANG, Claudia Veiga; ARAUJO, Ricardo Viera; CIRQUEIRA, Cinthya Santos; PARFIENIUK, Agata; GUZZO, Mariana F.; BENEDETTI, Anna Flavia F.; SOARES, Ibere C.; MILLAN, Maria Ines Perez; CAMPER, Sally Ann; CARVALHO, Luciani R. S.conferenceObject Evaluation of SSTR2, SSTR3 and SSTR5 and DRD2-Long and Short Isoforms Gene Expression in Nonfunctioning Pituitary Adenomas(2014) AMORIM, Paulo Vinicius Goncalves Holanda; TRARBACH, Ericka Barbosa; FORMIGA, Cristina B.; GUZZO, Mariana F.; CESCATO, Valter Angelo Sperling; GLEZER, Andrea; BRONSTEIN, Marcello D.conferenceObject Recovery of Hypopituitarism after Surgical or Medical Therapy for Pituitary Adenoma(2014) BRONSTEIN, Marcello D.; BUENO, Cristina B. F.; CACCELLI, Milena; GUZZO, Mariana F.; SICKLER, Thais P.; DUARTE, Felipe H. G.; GLEZER, Andrea; JALLAD, Raquel S.