LUIZ FELIPE PINHO MOREIRA

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 13
  • article
  • article 0 Citação(ões) na Scopus
    Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network
    (2017) ALFONSO, Fernando; ADAMYAN, Karlen; ARTIGOU, Jean-Yves; ASCHERMANN, Michael; BOEHM, Michael; BUENDIA, Alfonso; CHU, Pao-Hsien; COHEN, Ariel; CAS, Livio Dei; DILIC, Mirza; DOUBELL, Anton; ECHEVERRI, Dario; ENC, Nuray; FERREIRA-GONZALEZ, Ignacio; FILIPIAK, Krzysztof J.; FLAMMER, Andreas; FLECK, Eckart; GATZOV, Plamen; GINGHINA, Carmen; GONCALVES, Lino; HAOUALA, Habib; HASSANEIN, Mahmoud; HEUSCH, Gerd; HUBER, Kurt; HULIN, Ivan; IVANUSA, Mario; KRITTAYAPHONG, Rungroj; LAU, Chu-Pak; MARINSKIS, Germanas; MACH, Francois; MOREIRA, Luiz Felipe; NIEMINEN, Tuomo; OUKERRAJ, Latifa; PERINGS, Stefan; PIERARD, Luc; POTPARA, Tatjana; REYES-CAORSI, Walter; RIM, Se-Joong; RODEVAND, Olaf; SAADE, Georges; SANDER, Mikael; SHLYAKHTO, Evgeny; TIMURALP, Bilgin; TOUSOULIS, Dimitris; URAL, Dilek; PIEK, J. J.; VARGA, Albert; LUSCHER, Thomas F.
  • article 11 Citação(ões) na Scopus
    Bilateral sympathectomy improves postinfarction left ventricular remodeling and function
    (2017) ZANONI, Fernando Luiz; SIMAS, Rafael; SILVA, Raphael Grillo da; BREITHAUPT-FALOPPA, Ana Cristina; SILVA, Raphael dos Santos Coutinho e; JATENE, Fabio Biscegli; MOREIRA, Luiz Felipe P.
    Objectives: To evaluate the influence of bilateral or left sympathectomy on left ventricular remodeling and function after myocardial infarction in rats. Methods: Myocardial infarction was induced in rats by ligation of the left anterior descending coronary. Seven days later, rats were divided into 4 groups: the myocardial infarction, myocardial infarction with left sympathectomy, myocardial infarction with bilateral sympathectomy, and sham groups. After 8 weeks, left ventricular function was evaluated with the use of a pressure-volume conductance catheter under steady-state conditions and pharmacological stress. Infarct size and extracellular matrix fibrosis were evaluated, and cardiac matrix metalloproteinases and myocardial inflammatory markers were analyzed. Results: The myocardial infarction and left sympathectomy group had an increased end diastolic volume, whereas the bilateral sympathectomy group had a mean end-diastolic volume similar to that of the sham group (P <. 002). Significant reduction in ejection fraction was observed in the myocardial infarction and left sympathectomy group, whereas it was preserved after bilateral sympathectomy (P < .001). In response to dobutamine, left ventricular contractility increased in sham rats, rising stroke work, cardiac output, systolic volume, end-diastolic volume, ejection fraction, and dP/dt max. Only bilateral sympathectomy rats had significant increases in ejection fraction (P <. 001) with dobutamine. Fibrotic tissue and matrix metalloproteinase expression decreased in the bilateral sympathectomy group compared to that in the myocardial infarction group (P <. 001) and was associated with left ventricular wall thickness maintenance and better apoptotic markers in noninfarcted myocardium. Conclusions: Bilateral sympathectomy effectively attenuated left ventricular remodeling and preserved systolic function after myocardial infarction induction in rats.
  • article 21 Citação(ões) na Scopus
    Ethical Issues in the Use of Animal Models for Tissue Engineering: Reflections on Legal Aspects, Moral Theory, Three Rs Strategies, and Harm-Benefit Analysis
    (2017) LIGUORI, Gabriel R.; JERONIMUS, Bertus F.; LIGUORI, Tacia T. de Aquinas; MOREIRA, Luiz Felipe P.; HARMSEN, Martin C.
    Animal experimentation requires a solid and rational moral foundation. Objective and emphatic decision-making and protocol evaluation by researchers and ethics committees remain a difficult and sensitive matter. This article presents three perspectives that facilitate a consideration of the minimally acceptable standard for animal experiments, in particular, in tissue engineering (TE) and regenerative medicine. First, we review the boundaries provided by law and public opinion in America and Europe. Second, we review contemporary moral theory to introduce the Neo-Rawlsian contractarian theory to objectively evaluate the ethics of animal experiments. Third, we introduce the importance of available reduction, replacement, and refinement strategies, which should be accounted for in moral decision-making and protocol evaluation of animal experiments. The three perspectives are integrated into an algorithmic and graphic harm-benefit analysis tool based on the most relevant aspects of animal models in TE. We conclude with a consideration of future avenues to improve animal experiments.
  • conferenceObject
    EFFECTS OF 17BETA-ESTRADIOL ON A SUDDEN ONSET BRAIN DEATH MODEL IN MALE RATS
    (2017) VIEIRA, Roberta Figueiredo; BREITHAUPT-FALOPPA, Ana Cristina; MATSUBARA, Bruno Carvalho; RODRIGUES, Geovana; SANCHES, Marcelo Petrof; FERREIRA, Sueli Gomes; CORREIA, Cristiano De Jesus; MOREIRA, Luiz Felipe; SANNOMIYA, Paulina
  • article 1 Citação(ões) na Scopus
  • article 0 Citação(ões) na Scopus
    A New Experimental Device for Transapical Access of the Aortic and Mitral Valves as well as the Aorta in its Various Segments
    (2017) PALM, Leonardo; FONSECA, Jose Honorio Palma da; ARRUDA JUNIOR, Francismar Vidal de; GUTIERREZ, Paulo Sampaio; MOREIRA, Luiz Felipe Pinho; JATENE, Fabio Biscegli
    Objective: To present the results of a new experimental device developed to facilitate the transapical access in endovascular treatment of structural heart diseases. It aims to reduce the risk of bleeding and complications in this type of access and demonstrate the device as a safe, fast and effective alternative. Methods: CorPoint is composed of three parts: introducer, base with coiled spring, and closing capsule. By rotating movements, the spring is introduced into the myocardium and progressively approaches the base to the surface of the heart. Guidewires and catheters are inserted through the hollow central part and, at the end of the procedure, the capsule is screwed over the base, therefore stopping any bleeding. Results: The device was implanted in 15 pigs, weighing 60 kg each, through an anterolateral thoracotomy, while catheters were introduced and guided by fluoroscopy. All animals had minimal bleeding; introducers with diameter up to 22 Fr were used and various catheters and guidewires were easily handled. After finishing the procedure, the closing capsule was attached and no bleeding was observed at the site. Conclusion: This new device has proved effective, fast and secure for the transapical access. This shows great potential for use, especially by ensuring an easier and direct access to the mitral and aortic valves; the shortest distance to be traveled by catheters; access to the ascending and descending aorta; decreased bleeding complications; decreased surgical time; and the possibility of allowing the technique to evolve and become totally percutaneous.
  • article 1 Citação(ões) na Scopus
    Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network
    (2017) ALFONSO, Fernando; ADAMYAN, Karlen; ARTIGOU, Jean-Yves; ASCHERMANN, Michael; BOEHM, Michael; BUENDIA, Alfonso; CHU, Pao-Hsien; COHEN, Ariel; CAS, Livio Dei; DILIC, Mirza; DOUBELL, Anton; ECHEVERRI, Dario; ENC, Nuray; FERREIRA-GONZALEZ, Ignacio; FILIPIAK, Krzysztof J.; FLAMMER, Andreas; FLECK, Eckart; GATZOV, Plamen; GINGHINA, Carmen; GONCALVES, Lino; HAOUALA, Habib; HASSANEIN, Mahmoud; HEUSCH, Gerd; HUBER, Kurt; HULIN, Ivan; IVANUSA, Mario; KRITTAYAPHONG, Rungroj; LAU, Chu-Pak; MARINSKIS, Germanas; HUBER, Kurt; HULIN, Ivan; IVANUSA, Mario; KRITTAYAPHONG, Rungroj; LAU, Chu-Pak; MARINSKIS, Germanas; MACH, Francois; MOREIRA, Luiz Felipe; NIEMINEN, Tuomo; OUKERRAJ, Latifa; PERINGS, Stefan; PIERARD, Luc; POTPARA, Tatjana; REYES-CAORSI, Walter; RIM, Se-Joong; RODEVAND, Olaf; SAADE, Georges; SANDER, Mikael; SHLYAKHTO, Evgeny; TIMURALP, Bilgin; TOUSOULIS, Dimitris; URAL, Dilek; PIEK, J. J.; VARGA, Albert; LUSCHER, Thomas F.
    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology.
  • article 1 Citação(ões) na Scopus
    Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network
    (2017) ALFONSO, Fernando; ADAMYAN, Karlen; ARTIGOU, Jean-Yves; ASCHERMANN, Michael; BOEHM, Michael; BUENDIA, Alfonso; CHU, Pao-Hsien; COHEN, Ariel; CAS, Livio Dei; DILIC, Mirza; DOUBELL, Anton; ECHEVERRI, Dario; ENC, Nuray; FERREIRA-GONZALEZ, Ignacio; FILIPIAK, Krzysztof J.; FLAMMER, Andreas; FLECK, Eckart; GATZOV, Plamen; GINGHINA, Carmen; GONCALVES, Lino; HAOUALA, Habib; HASSANEIN, Mahmoud; HEUSCH, Gerd; HUBER, Kurt; HULIN, Ivan; IVANUSA, Mario; KRITTAYAPHONG, Rungroj; LAU, Chu-Pak; MARINSKIS, Germanas; MACH, Francois; MOREIRA, Luiz Felipe; NIEMINEN, Tuomo; OUKERRAJ, Latifa; PERINGS, Stefan; PIERARD, Luc; POTPARA, Tatjana; REYES-CAORSI, Walter; RIM, Se-Joong; RODEVAND, Olaf; SAADE, Georges; SANDER, Mikael; SHLYAKHTO, Evgeny; TIMURALP, Bilgin; TOUSOULIS, Dimitris; URAL, Dilek; PIEK, J. J.; VARGA, Albert; LUSCHER, Thomas F.
    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology.
  • conferenceObject
    EFFECTS OF HYPERTONIC SALINE SOLUTION ON CARDIAC AND PULMONARY CHANGES AFTER BRAIN DEATH: AN EXPERIMENTAL STUDY
    (2017) CORREIA, Cristiano; MAGGALHAES, Daniel M.; ZANONI, Fernando; SIMAS, Rafael; SOARES, Rafaela Garcia Ferreira; SILVA, Raphael S. Coutinho E; BREITHAUPT-FALOPPA, Ana Cristina; SANNOMIYA, Paulina; MOREIRA, Luiz Felipe