LUIZ FELIPE PINHO MOREIRA

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Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina - Líder

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Assunto: Cardiac & Cardiovascular Systems ×

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Agora exibindo 1 - 10 de 71
  • conferenceObject
    Impact of sympathectomy upon myocardium
    (2019) PESSOA, F. Fernanda; JORDAO, M. R.; FONSECA, K. C. B.; ZANONI, F.; SALEMI, V. M. C.; RIBEIRO, O. N.; SOUZA, L. E.; FERNANDES, F.; IRIGOYEN, M. C.; MOREIRA, L. F. P.; MADY, C.; RAMIRES, F. J. A.
  • article 19 Citação(ões) na Scopus
    EuroSCORE II and the importance of a local model, InsCor and the future SP-SCORE
    (2014) LISBOA, Luiz Augusto Ferreira; MEJIA, Omar Asdrubal Vilca; MOREIRA, Luiz Felipe Pinho; DALLAN, Luis Alberto Oliveira; POMERANTZEFF, Pablo Maria Alberto; DALLAN, Luis Roberto Palma; MASSOTI, Maria Raquel B.; JATENE, Fabio B.
    Introduction: The most widely used model for predicting mortality in cardiac surgery was recently remodeled, but the doubts regarding its methodology and development have been reported. Objective: The aim of this study was to evaluate the performance of the EuroSCORE II to predict mortality in patients undergoing coronary artery bypass grafts or valve surgery at our institution. Methods: One thousand consecutive patients operated on coronary artery bypass grafts or valve surgery, between October 2008 and July 2009, were analyzed. The outcome of interest was in-hospital mortality. Calibration was performed by correlation between observed and expected mortality by Hosmer Lemeshow. Discrimination was calculated by the area under the ROC curve. The performance of the EuroSCORE II was compared with the EuroSCORE and InsCor (local model). Results: In calibration, the Hosmer Lemeshow test was inappropriate for the EuroSCORE II (P=0.0003) and good for the EuroSCORE (P=0.593) and InsCor (P=0.184). However, the discrimination, the area under the ROC curve for EuroSCORE II was 0.81 [95% CI (0.76 to 0.85), P<0.001], for the EuroSCORE was 0.81 [95% CI (0.77 to 0.86), P<0.001] and for InsCor was 0.79 [95% CI (0.74-0.83), P<0.001] showing up properly for all. Conclusion: The EuroSCORE II became more complex and resemblance to the international literature poorly calibrated to predict mortality in patients undergoing coronary artery bypass grafts or valve surgery at our institution. These data emphasize the importance of the local model.
  • article 2 Citação(ões) na Scopus
  • article
  • conferenceObject
    Bilateral Sympathetic Denervation Improves Left Ventricular Function and Prevents Post-Infarction Chamber Remodeling in Rats
    (2016) ZANONI, F. L.; MOREIRA, L. F.; SIMAS, R.; SILVA, R. G. da; JATENE, F. B.
  • article 0 Citação(ões) na Scopus
    Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network
    (2017) ALFONSO, Fernando; ADAMYAN, Karlen; ARTIGOU, Jean-Yves; ASCHERMANN, Michael; BOEHM, Michael; BUENDIA, Alfonso; CHU, Pao-Hsien; COHEN, Ariel; CAS, Livio Dei; DILIC, Mirza; DOUBELL, Anton; ECHEVERRI, Dario; ENC, Nuray; FERREIRA-GONZALEZ, Ignacio; FILIPIAK, Krzysztof J.; FLAMMER, Andreas; FLECK, Eckart; GATZOV, Plamen; GINGHINA, Carmen; GONCALVES, Lino; HAOUALA, Habib; HASSANEIN, Mahmoud; HEUSCH, Gerd; HUBER, Kurt; HULIN, Ivan; IVANUSA, Mario; KRITTAYAPHONG, Rungroj; LAU, Chu-Pak; MARINSKIS, Germanas; MACH, Francois; MOREIRA, Luiz Felipe; NIEMINEN, Tuomo; OUKERRAJ, Latifa; PERINGS, Stefan; PIERARD, Luc; POTPARA, Tatjana; REYES-CAORSI, Walter; RIM, Se-Joong; RODEVAND, Olaf; SAADE, Georges; SANDER, Mikael; SHLYAKHTO, Evgeny; TIMURALP, Bilgin; TOUSOULIS, Dimitris; URAL, Dilek; PIEK, J. J.; VARGA, Albert; LUSCHER, Thomas F.
  • article 3 Citação(ões) na Scopus
    Transforming growth factor-beta 1 SMAD effectors and medial cell number in ascending aorta diseases
    (2016) APARECIDA-SILVA, Rosemeire; BORGES, Luciano Figueiredo; KESSLER, Ketty; DIAS, Ricardo Ribeiro; MOREIRA, Luiz Felipe Pinho; KALIL, Jorge; GUTIERREZ, Paulo Sampaio
    In ascending aorta aneurysms and dissections, the extracellular matrix is degraded. Transforming growth factor (TGF)-beta 1 modulates its synthesis. The production and presence of SMADs, intracellular effectors of TGF-beta 1 signaling, were analyzed in patients with these diseases. To verify whether medial cells are lost, their total numbers were computed. Ascending aorta samples from 19 patients and 18 controls underwent immunoperoxidase reactions to SMADs 2, 3, 4, and 7. Positive and negative cells were counted, and total numbers of cells and positive/total ratios were calculated. Samples from other 14 patients and 7 normal controls were used for the quantification of SMAD3, SMAD4, and SMAD7 mRNA. For SMAD4, both mRNA (2.36 vs. 0.37, P=. 03) and ratio of positive cells (0.94 vs. 0.73, P=. 02) are increased in patients with ascending aortic diseases. SMAD3 mRNA was also increased (1.19 vs. 0.20, P=. 05). The cell ratios of this and the other SMADs, SMAD7 mRNA, and the total cell count did not differ between groups. In conclusion, in ascending aortic aneurysms and dissections, there is an increase in SMAD4, implicated in extracellular matrix production, possibly as an attempt to compensate for extracellular matrix deficiency. Lost medial cells are replaced, since their number is not diminished.
  • article 0 Citação(ões) na Scopus
  • conferenceObject
    Sexual Dimorphism in Lung Inflammatory Process After Brain Death Induction in Rats
    (2014) MOREIRA, L. P.; FERREIRA, S. G.; KUDO, G. K.; CORREIRA, C. J.; TAVARES-DE-LIMA, W.; BREITHAUPT-FALOPPA, A. C.; SANNOMIYA, P.
  • article 11 Citação(ões) na Scopus
    Bilateral sympathectomy improves postinfarction left ventricular remodeling and function
    (2017) ZANONI, Fernando Luiz; SIMAS, Rafael; SILVA, Raphael Grillo da; BREITHAUPT-FALOPPA, Ana Cristina; SILVA, Raphael dos Santos Coutinho e; JATENE, Fabio Biscegli; MOREIRA, Luiz Felipe P.
    Objectives: To evaluate the influence of bilateral or left sympathectomy on left ventricular remodeling and function after myocardial infarction in rats. Methods: Myocardial infarction was induced in rats by ligation of the left anterior descending coronary. Seven days later, rats were divided into 4 groups: the myocardial infarction, myocardial infarction with left sympathectomy, myocardial infarction with bilateral sympathectomy, and sham groups. After 8 weeks, left ventricular function was evaluated with the use of a pressure-volume conductance catheter under steady-state conditions and pharmacological stress. Infarct size and extracellular matrix fibrosis were evaluated, and cardiac matrix metalloproteinases and myocardial inflammatory markers were analyzed. Results: The myocardial infarction and left sympathectomy group had an increased end diastolic volume, whereas the bilateral sympathectomy group had a mean end-diastolic volume similar to that of the sham group (P <. 002). Significant reduction in ejection fraction was observed in the myocardial infarction and left sympathectomy group, whereas it was preserved after bilateral sympathectomy (P < .001). In response to dobutamine, left ventricular contractility increased in sham rats, rising stroke work, cardiac output, systolic volume, end-diastolic volume, ejection fraction, and dP/dt max. Only bilateral sympathectomy rats had significant increases in ejection fraction (P <. 001) with dobutamine. Fibrotic tissue and matrix metalloproteinase expression decreased in the bilateral sympathectomy group compared to that in the myocardial infarction group (P <. 001) and was associated with left ventricular wall thickness maintenance and better apoptotic markers in noninfarcted myocardium. Conclusions: Bilateral sympathectomy effectively attenuated left ventricular remodeling and preserved systolic function after myocardial infarction induction in rats.