MAURICIO IBRAHIM SCANAVACCA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/65, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/65, Hospital das Clínicas, Faculdade de Medicina - Líder
5 resultados
Resultados de Busca
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- Redução da Densidade de Extrassístoles e dos Sintomas Relacionados após Administração de Magnésio por Via Oral(2012) FALCO, Cristina Nadja Muniz Lima De; GRUPI, Cesar; SOSA, Eduardo; SCANAVACCA, Mauricio; HACHUL, Denise; LARA, Sissy; SACILOTTO, Luciana; PISANI, Cristiano F.; RAMIRES, Jose A. F.; DARRIEUX, FranciscoBackground: Premature ventricular and supraventricular complexes (PVC and PsVC) are frequent and often symptomatic. The magnesium (Mg) ion plays a role in the physiology of cell membranes and cardiac rhythm. Objective: We evaluated whether the administration of Mg Pidolate (MgP) in patients with PVC and PsVC is superior to placebo (P) in improving symptoms and arrhythmia frequency. Methods: Randomized double-blind study with 60 consecutive symptomatic patients with more than 240 PVC or PsVC/h on 24-hour Holter monitoring who were selected to receive placebo or MgP. To evaluate symptom improvement, a categorical and a specific questionnaire for symptoms related to PVC and PsVC was made. Improvement in premature complex density (PCD) per hour was considered significant if percentage reduction was >= 70% after treatment. The dose of MgP was 3.0 g/day for 30 days, equivalent to 260mg of Mg element. None of the patients had structural heart disease or renal failure. Results: Of the 60 patients, 33 were female (55%). Ages ranged from 16 to 70 years old. In the MgP group, 76.6% of patients had a PCD reduction >70%, 10% of them >50% and only 13.4% <50%. In the P group, 40% showed slight improvement, <30%, in the premature complexes frequency (p < 0.001). Symptom improvement was achieved in 93.3% of patients in the MgP group, compared with only 16.7% in the P group (p < 0.001). Conclusion: Oral Mg supplementation decreases PCD, resulting in symptom improvement. (Arq Bras Cardiol 2012;98(6):480-487)
- RHYTHM-AF: design of an international registry on cardioversion of atrial fibrillation and characteristics of participating centers(2012) CRIJNS, Harry J. G. M.; BASH, Lori D.; CHAZELLE, Francois; HEUZEY, Jean-Yves Le; LEWALTER, Thorsten; LIP, Gregory Y. H.; MAGGIONI, Aldo P.; MARTIN, Alfonso; PONIKOWSKI, Piotr; ROSENQVIST, Marten; SANDERS, Prashanthan; SCANAVACCA, Mauricio; BERNHARDT, Alexandra A.; UNNIACHAN, Sreevalsa; PHATAK, Hemant M.; GITT, Anselm K.Background: Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and the associated health outcomes. Methods/design: RHYTHM-AF was a prospective observational multinational study of management of recent onset atrial fibrillation patients considered for cardioversion designed to collect data on international treatment patterns and short term outcomes related to cardioversion. We present data collected in 10 countries between May 2010 and June 2011. Enrollment was ongoing in Italy and Brazil at the time of data analysis. Data were collected at the time of atrial fibrillation episode in all countries (Australia, Brazil, France, Germany, Italy, Netherlands, Poland, Spain, Sweden, United Kingdom), and cumulative follow-up data were collected at day 60 (+/- 10) in all but Spain. Information on center characteristics, enrollment data, patient demographics, detail of atrial fibrillation episode, medical history, diagnostic procedures, acute treatment of atrial fibrillation, discharge information and the follow-up data on major events and rehospitalizations up to day 60 were collected. Discussion: A total of 3940 patients were enrolled from 175 acute care centers. 70.5% of the centers were either academic (44%) or teaching (26%) hospitals with an overall median capacity of 510 beds. The sites were mostly specialized with anticoagulation clinics (65.9%), heart failure (75.1%) and hypertension clinics (60.1%) available. The RHYTHM-AF registry will provide insight into regional variability of antiarrhythmic and antithrombotic treatment of atrial fibrillation, the appropriateness of such treatments with respect to outcomes, and their cost-efficacy. Observations will help inform strategies to improve cardiovascular outcomes in patients with atrial fibrillation.
- New Perspectives in the Treatment of Cardiac Arrhythmias and Their Application in Brazil(2012) SCANAVACCA, Mauricio
- Radiofrequency Ablation of Childhood Arrhythmia. Observational Registry in 125 Children(2012) MELO, Sissy Lara de; SCANAVACCA, Mauricio Ibrahim; PISANI, Cristiano; DARRIEUX, Francisco; HACHUL, Denise; HARDY, Carina; CAMARGO, Paulo Roberto; ATIK, Edmar; SOSA, Eduardo ArgentinoBackground: Radiofrequency ablation (RFA) in children is an increasingly common practice. Objective: To evaluate, in our institution, the results of RFA in children younger than 15 years. Methods: A total of 125 children submitted to RFA between May 1991 and May 2010 were analyzed. Results: Sixty-seven (53.6%) children were males, aged between 44 days and 15 years (mean 8.6 +/- 3.3 years) with median weight of 31 kg. Heart disease was present in 21 (16.8%) patients. The RFA of accessory pathways (AP) was the most common procedure (62 children - 49.6%). The RFA of nodal reentrant tachycardia (NRT) was the second most common arrhythmia in 27 (21.6%), followed by atrial tachycardia (AT) in 16 (12.8%) and ventricular tachycardias (VT) in 8 (6.4%) children. The success criteria were achieved in 86.9%, 96.1%, 80% and 62.5% of patients undergoing RFA of AP, NRT, AT and VT, respectively. Transient AVB occurred during RFA in 4 (3.2%) and LBBB in 7 (5.6%) children. Twenty-five children underwent a new RFA due to initial failure or recurrence. During the mean follow up of 5.5 +/- 3.4 years, 107 (88.4%) remained without recurrence. There was no statistical difference regarding the results and the age at which the patient underwent the procedure. No child had persistent AVB or required a permanent pacemaker. Conclusion: Catheter ablation is a safe and effective alternative therapy in children with recurrent tachycardias refractory to medical treatment. (Arq Bras Cardiol 2012;98(6):514-518)
- Wide complex tachycardia: An unusual presentation(2012) CARMO, Andre A. L.; MELO, Sissy L.; SCANAVACCA, Mauricio I.; SOSA, Eduardo