MAURICIO SIMOES ABRAO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
conferenceObject LONG-TERM SAFETYAND EFFICACY OF ELAGOLIX TREATMENT IN WOMEN WITH ENDOMETRIOSIS ASSOCIATED PAIN: PRIMARY RESULTS FROM TWO PHASE 3 EXTENSION STUDIES.(2017) SURREY, E.; TAYLOR, H. S.; GIUDICE, L. C.; SINGH, S.; ABRAO, M. S.; LESSEY, B. A.; DUAN, W. R.; PELOSO, P. M.; SCHWEFEL, B.; CHWALISZ, K.- LEUKOCYTE TELOMERE LENGTH IS LONGER IN PATIENTS WITH ENDOMETRIOSIS COMPARED TO CONTROLS.(2013) DRACXLER, R. C.; KALMBACH, K. H.; WANG, F.; ABRAO, M. S.; KEEFE, D. L.
- Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis(2013) BELLELIS, Patrick; BARBEIRO, Denise Frediani; RIZZO, Luiz Vicente; BARACAT, Edmund Chada; ABRAO, Mauricio Simoes; PODGAEC, SergioObjective: To evaluate the expression of chemokines that regulate natural killer (NK) and T-regulatory (T-reg) cell activity in eutopic and ectopic endometrial tissue samples from endometriosis patients. Design: Case-control study (Canadian Task Force classification II-2). Setting: Tertiary referral hospital. Patient(s): Sixty-four consecutive patients with and without endometriosis. Intervention(s): After videolaparoscopy, patients were divided into three groups: bowel endometriosis (n = 22), retrocervical endometriosis (n = 10), and endometriosis-free women (n = 32). Main Outcome Measure(s): Gene expression of the chemokines that regulate NK (CXCL9, CXCL10, CXCL11, CXCL12, XCL1, and CX3CL1) and T-reg cell activity (CCL17 and CCL21) evaluated by real-time polymerase chain reaction. Result(s): Of the chemokines associated with NK cells, CX3CL1 and CXCL12 expression was statistically significantly greater in the foci of endometriosis compared with the eutopic endometrium in patients and controls. From the chemokines associated with T-reg cells, CCL17 expression was statistically significantly greater in the eutopic endometrium of the patients with rectosigmoid endometriosis compared with the foci of endometriosis or eutopic endometrium of the patients with retrocervical endometriosis or the disease-free women. Conclusion(s): Both T-reg and NK cells mediate inflammatory response and may play a fundamental role in endometriosis by causing an impaired clearing of endometrial cells. Establishing how CCL17, CXCL12, and CX3CL1 modulate this response is essential to understanding inflammatory responses in endometriosis. (Fertil Steril (R) 2013; 99: 1987-93. (C) 2013 by American Society for Reproductive Medicine.)
- Endometriosis and recurrent pregnancy loss: two manifestations of the same underlying dysfunction?(2023) VIDALI, Andrea; RICCIO, Luiza Gama Coelho; ABRAO, Mauricio Simoes
- ELAGOLIX REDUCED DYSPAREUNIA AND IMPROVED HEALTH-RELATED QUALITY OF LIFE IN PREMENOPAUSAL WOMEN WITH ENDOMETRIOSIS-ASSOCIATED PAIN.(2018) LEYLAND, N.; TAYLOR, H. S.; ARCHER, D. F.; PELOSO, P. M.; SCHWEFEL, B.; SOLIMAN, A. M.; MARTINEZ, M.; ABRAO, M. S.
conferenceObject IDENTIFICATION OF IMMUNOLOGIC PREDICTIVE BIOMARKERS OF ENDOMETRIOSIS USING A NON-INVASIVE IMMUNE SCREENING TEST IN ASSOCIATION WITH MACHINE LEARNING MODELING(2023) ATTIA, Nadera Mansouri; FRANZOI, Marco; MCHALE, Melissa P.; GARGIULO, Antonio R.; ABRAO, Mauricio S.; VIDALI, Andrea- Increased expression of antimullerian hormone and its receptor in endometriosis(2014) CARRARELLI, Patrizia; ROCHA, Ana Luiza Lunardi; BELMONTE, Giuseppe; ZUPI, Errico; ABRAO, Mauricio Simoes; ARCURI, Felice; PIOMBONI, Paola; PETRAGLIA, FeliceObjective: To evaluate antimullerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. Design: Prospective study. Setting: University hospitals in Italy and Brazil. Patients: Patients with endometriosis (n = 55) and healthy women (n = 45). Interventions: Specimens of endometrium obtained by hysteroscopy from patients with endometriosis and from healthy control subjects; specimens of ovarian endometriosis (n = 29) or of deep endometriosis (n = 26) were collected by laparoscopy. Serum samples were collected in some endometriotic patients (n = 23) and healthy control subjects (n = 20). Main Outcome Measure(s): AMH and AMHRII mRNA levels were evaluated by quantitative reverse-transcription polymerase chain reaction and protein localization by immunohistochemistry. AMH levels in tissue homogenates and in serum were assessed by ELISA. Result(s): Endometrium from women with endometriosis showed higher AMH and AMHRII mRNA levels than control women, with no significant differences between proliferative and secretory phases. Specimens collected from ovarian or deep endometriosis showed the highest AMH and AMHRII mRNA expression. Immunolocalization study confirmed the high AMH and AMHRII protein expression in endometriotic lesions. No difference of serum AMH levels between the groups was found. Conclusion(s): The increased AMH and AMHRII mRNA and protein expression in endometrium and in endometriotic lesions suggests a possible involvement of AMH in endometriosis. (C) 2014 by American Society for Reproductive Medicine.
- Mycoplasma genitalium can modulate the local immune response in patients with endometriosis(2018) CAMPOS, Guilherme B.; MARQUES, Lucas M.; REZENDE, Izadora S.; BARBOSA, Maysa S.; ABRAO, Mauricio S.; TIMENETSKY, JorgeObjective: To detect Mollicutes in women with endometriosis and healthy peritoneal tissues and evaluate the participation of these bacteria in the immune response during endometriosis. Design: Cross-sectional study. Setting: University hospitals. Patient (s): Women with endometriosis (n = 73) and without endometriosis (n = 31). Intervention(s): Endocervical swabs, peritoneal fluid, and biopsied lesions of endometriosis of women with endometriosis (study group) and healthy peritoneal tissues (control group) were collected during surgery. Clinical characteristics were registered before surgery. Main Outcome Measure(s): We determined the infectious agents with the use of quantitative polymerase chain reaction (PCR). The cytokine secretion profile was determined with the use of Luminex. The expression of immune response related genes was determined with the use of a PCR array kit. Result(s): All target microorganisms were detected at least once in the swab samples analyzed. It was possible to observe higher diversity of microorganisms in the samples of swab and peritoneal fluid in the study group compared with the control. Ureaplasma parvum was associated with the severity of the symptom dyspareunia. Mycoplasma genitalium was associated with higher production of interferon-g and interleukin-1b. Genes of inflammatory response activation and antigen presentation were up-regulated in biopsied tissue of women with endometriosis. In women with endometriosis, peritoneal fluid cells showed a down-regulation of genes associated with the inflammatory response. This down-regulation profile was higher in presence of M. genitalium. Conclusion(s): Mycoplasma genitalium may play a key role in the immune tolerance process and, especially, the aggravation of this profile. More studies are needed to understand this immune tolerance profile of bacterial infections. (C) 2017 by American Society for Reproductive Medicine.