LUIZ FERNANDO PORTUGAL FUCHS
Projetos de Pesquisa
Unidades Organizacionais
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Melatonin may influence CYP19 immunoexpression in ovary of female rats in proestrous phase(2013) SASSO, Gisela R.; MAGANHIN, Carla C.; FUCHS, Luizf.; FRANCO, Paulo Celso; FLORENCIO-SILVA, Rinaldo; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose M.conferenceObject Immunoexpression of ERK2/p42 MAPK in the ovary of pinealectomized female rats in proestrous phase treated with melatonin(2013) MAGANHIN, Carla C.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; FUCHS, Luiz F.; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose M.conferenceObject Immunoexpression of vascular endothelial growth factor (VEGF-A) in the uterus of pinealectomized female rats treated with melatonin(2013) MAGANHIN, Carla C.; SASSO, Gisela R.; FLORENCIO-SILVA, Rinaldo; FUCHS, Luiz F.; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose M.conferenceObject Imunoexpression of BCL-2 and BAX in ovarian follicles of pinealectomized or melatonin-treated pinealectomized rats(2015) FUCHS, Luiz F.; MAGANHIN, Carla C.; SASSO, Gisela R.; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose MariaconferenceObject CYP17 immunoexpression in ovary of pinealectomized female rats in proestrous phase treated with melatonin(2013) MAGANHIN, Carla C.; SASSO, Gisela R.; FUCHS, Luiz F.; FLORENCIO-SILVA, Rinaldo; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES- JR., Jose M.conferenceObject Expression and influence ovarian function by the upregulation and downregulation of steroidogenesis related genes in ovary of pinealectomized rats in proestrous phase: Folistatin and Inhibin-beta A(2015) MAGANHIN, Carla C.; FUCHS, Luiz F.; SIMOES, Ricardo S.; SASSO, Gisela R.; BARACAT, Edmund C.; SOARES- JR., Jose MariaconferenceObject Melatonin may influence ovarian function by the overexpression and down-regulation of steroidogenesis related genes in ovary of pinealectomized rats in proestrus phase(2013) MAGANHIN, Carla C.; SASSO, Gisela R.; FUCHS, Luiz F.; FLORENCIO-SILVA, Rinaldo; SIMOES, Ricardo S.; BARACAT, Edmund Chada; SOARES- JR., Jose M.- Melatonin influences on steroidogenic gene expression in the ovary of pinealectomized rats(2014) MAGANHIN, Carla C.; SIMOES, Ricardo S.; FUCHS, Luiz F. P.; SASSO, Gisela R. S.; SIMOES, Manuel J.; BARACAT, Edmund C.; SOARES JR., Jose M.Objective: To analyze the expression of genes related to steroidogenesis in the ovary of pinealectomized rats. Design: Experimental research. Setting: University research laboratory. Animal(s): Thirty female adult rats. Intervention(s): Administration of vehicle (GI), pinealectomy with vehicle (GII), or pinealectomy with melatonin replacement (10 mu g/night) for 60 consecutive days (GIII), then euthanasia after 2 months of treatment, ovary collection complementary DNA microarray analyses, confirmatory quantitative reverse-transcriptase polymerase chain reaction analyses, and immunohistochemical analyses for localizing steroidogenesis changes in the ovary. Main Outcome Measure(s): Biologic molecular study followed by immunohistochemical analysis. Result(s): The changes in the expression of CYP11A1, CYP17A1, and CYP19A1 after pinealectomy (GII) compared with control (GI) showed the Cyp17a1 expression level increased in the theca interna and interstitial cells in the GII rats compared with the other groups. Conclusion(s): Melatonin deprivation (pinealectomy) or administration may influence the ovarian CYP17A1 expression and steroidogenesis. (C)2014 by American Society for Reproductive Medicine.
conferenceObject Imnunoexpression of estrogen receptors may decrease produce melatonin in ovaries of pinealectomized female rats(2015) MAGANHIN, Carla C.; FUCHS, Luiz F.; SASSO, Gisela R.; SIMOES, Ricardo S.; BARACAT, Edmund C.; SOARES JUNIOR, Jose M.