MARIANA MATERA VERAS
Projetos de Pesquisa
Unidades Organizacionais
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject IMPACTS OF RECREATIONAL USE OF CANNABIS SATIVA ON GESTATIONAL AND DEVELOPMENTAL OUTCOMES IN MICE: PRELIMINARY RESULTS(2015) BENEVENUTO, S. G. M.; BELOTTI, L.; COSTA, N. S. X.; DOLHNIKOFF, M.; RIBEIRO JUNIOR, G.; LOURENCO, D. T.; VERAS, M. M.conferenceObject Chronicle air pollution exposition and semen quality in hypercolesterolemic mice(2013) PERES, M. A.; CASTRO, K.; RIBEIRO-JUNIOR, G.; MENDES, C.; LOSANO, J.; VERAS, M.; SALDIVA, P.Air pollution (AP) is associated to lose of semen quality. It is also known that some population groups are more susceptible to atmospheric pollution effects due to a pre-existing health condition. This work detailed the effects AP in semen quality of mice knockout for low density lipoprotein receptor that represents an important risk group of human population. Animals were exposed to AP during pre and/or post natal period until adult life, with or without hypercholesterolemic diet. Semen analysis comprised sperm number and morphology, membrane, acrosome and DNA integrity, mitochondrial activity, oxidative stress and cytokines expression of seminal vesicle. The combination of the three factors (AP pre/post natal exposure and hypercholesterolemia) negatively impacted DNA fragmentation, mitochondrial activity, membrane integrity and oxidative stress. Other parameters did not show significant differences. Air pollution combined with hypercholesterolemia condition potentiated the negative effects on important parameters of semen leading male mice to present low fertility/infertility.- NEGATIVE EFFECTS OF SMOKING MARIJUANA DURING PREGNANCY ON THE PLACENTA: EXPERIMENTAL EVIDENCE(2019) VERAS, Mariana; BENEVENUTO, Sarah; TORRES, Janaina; YARIWAKE, Victor; MORAES, Thamires; SILVA, Iran
- ADVANCED MATERNAL AGE AND PLACENTAL MORPHOFUNCTIONAL CHANGES: AN EXPERIMENTAL STUDY IN MICE(2017) TORRES, J. I.; NEVES, I. A.; YARIWAKE, V. Y.; MIGLINO, M. A.; VERAS, M. M.
- SERUM OF PATIENTS WITH PREECLAMPSIA ACTIVATES UPR-PERK PATHWAY IN HUMAN TROPHOBLAST CELL LINE HTR8/SVNEO(2019) CASTRO, Karla; PRADO, Karen; LORENZON-OJEA, Aline; FRANCISCO, Rossana; ZUGAIB, Marcelo; HOSHIDA, Mara; ALVES, Eliane; VERAS, Mariana; BEVILACQUA, Estela
conferenceObject FINE PARTICULATE MATTER IN THE AIR WITHIN THE LIMITS RECOMMENDED BY WHO ALTERS PLACENTAL STRUCTURE(2014) SOTO, Sonia; LOPES, Karen; OLIVEIRA, Ivone; SOUZA, Regiane; MARCHESI, Guilherme; VERAS, Mariana; HEIMANN, Joel- Hypoxia: From Placental Development to Fetal Programming(2017) FAJERSZTAJN, Lais; VERAS, Mariana MateraHypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them regulated by hypoxia-inducible factor 1 complex, which is mostly involved in cellular control of O-2 consumption and delivery, inhibition of growth and development, and promotion of anaerobic metabolism. Hypoxia plays a significant physiological role in fetal development; it is involved in different embryonic processes, for example, placentation, angiogenesis, and hematopoiesis. More recently, fetal hypoxia has been associated directly or indirectly with fetal programming of heart, brain, and kidney function and metabolism in adulthood. In this review, the role of hypoxia in fetal development, placentation, and fetal programming is summarized. Hypoxia is a basic mechanism involved in different pregnancy disorders and fetal health developmental complications. Although there are scientific data showing that hypoxia mediates changes in the growth trajectory of the fetus, modulates gene expression by epigenetic mechanisms, and determines the health status later in adulthood, more mechanistic studies are needed. Furthermore, if we consider that intrauterine hypoxia is not a rare event, and can be a consequence of unavoidable exposures to air pollution, nutritional deficiencies, obesity, and other very common conditions (drug addiction and stress), the health of future generations may be damaged and the incidence of some diseases will markedly increase as a consequence of disturbed fetal programming. (C) 2017 Wiley Periodicals, Inc.
- EXPRESSION OF ENDOPLASMIC RETICULUM STRESS MARKERS IN CHORIONIC VILLI TREATED WITH SERUM FROM PATIENTS WITH PRE-ECLAMPSIA(2017) CASTRO, Karla; PRADO, Karen; LORENZON-OJEA, Aline; SMUZCEK, Basilio; HOSHIDA, Mara; FRANCISCO, Rossana; ZUGAIB, Marcelo; ALVES, Eliane; VERAS, Mariana; BEVILACQUA, Estela
conferenceObject Murine uterine receptivity markers are affected by particulate air pollution in a dose response manner(2013) CASTRO, K. R.; RIBEIRO-JUNIOR, R.; PERES, M.; SALDIVA, P.; MATSUDA, M.; VERAS, M.Air pollution (AP) is associated with increased rates of implantation failures in mice. The uterus requires a variety of factors to become receptive: cytokines (LIF), anti-adhesion (MUC-1) molecules and hormonal induced morphological changes. This study investigated the effects of chronic exposure to AP on uterine receptivity. Female mice were exposed to either filtered air or 2 different daily doses of AP. Estrous cycle, ovarian and uterine weight, number of corpora lutea (CL), uterine histopathology, LIF and MUC-1 expression were evaluated. Effects were dose dependent. Estrous cycle showed shorter duration with extended diestrus. Ovarian weights were increased without change in CL number. Histopathology indicated a decrease in volume and thickness of endometrium and increased diameter and thickness of glandular and luminal epithelium. MUC-1 expression was not altered but LIF was decreased during the implantation window. This suggests that AP exposure negatively affects endometrial receptivity altering the fine regulation of decidualization mediated by LIF expression.conferenceObject Exposure to air pollution before and during pregnancy: Effect on placental structure(2013) SOTO, S. F.; VERAS, M. M.; HEIMANN, J. L.Objective: To evaluate the effects of exposure to air pollution before and during pregnancy. Methods: Female Wistar rats were exposed to filtrated (F) or polluted (P) air in an Atmospheric Particle Concentrator during 3 weeks before pregnancy. At 12 weeks of age, the animals were mated and pregnant females divided in four subgroups (FF, FP, PF and PP). At 19th day of pregnancy, placentas were collected. Placental (Pl) and deciduous (Dc) longitudinal (LD) and transversal (TD) diameters were measured. Results:(mean SEM–p<0.05 mm): 1p<0.05 vs FF; 2p<0.05 vs FF, PF, PP; 3p<0.05 vs FF; 4p<0.05 vs FF, PP; 5p<0.05 vs FF; 6p<0.05 vs PF Conclusions: Exposure to air pollution affects placental structure indicating a possible impairment of fetal nutrition.