TIFFANY MOUKBEL CHAIM AVANCINI
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
5 resultados
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bookPart Abuso e dependência de drogas(2014) SCIVOLETTO, Sandra; CHAIM, TiffanyconferenceObject PLA2 GENE EXPRESSION IN FIRST EPISODE DRUG NAIVE PATIENTS(2014) KERR, Daniel S.; SERPA, Mauricio; TALIB, Leda L.; BILT, Martinus Theodorus Van De; ALCANTARA, Juliana; CHAIM, Tiffany; BUSATTO, Geraldo; ZANETTI, Marcus; GATTAZ, WagnerbookPart Drogas e adolescência: aspectos epidemiológicos, uso e consequências(2014) SCIVOLETTO, Sandra; CHAIM, Tiffany- Multimodal Magnetic Resonance Imaging Study of Treatment-Naive Adults with Attention-Deficit/Hyperactivity Disorder(2014) CHAIM, Tiffany M.; ZHANG, Tianhao; ZANETTI, Marcus V.; SILVA, Maria Aparecida da; LOUZA, Mario R.; DOSHI, Jimit; SERPA, Mauricio H.; DURAN, Fabio L. S.; CAETANO, Sheila C.; DAVATZIKOS, Christos; BUSATTO, Geraldo F.Background: Attention-Deficit/Hiperactivity Disorder (ADHD) is a prevalent disorder, but its neuroanatomical circuitry is still relatively understudied, especially in the adult population. The few morphometric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) studies available to date have found heterogeneous results. This may be at least partly attributable to some well-known technical limitations of the conventional voxel-based methods usually employed to analyze such neuroimaging data. Moreover, there is a great paucity of imaging studies of adult ADHD to date that have excluded patients with history of use of stimulant medication. Methods: A newly validated method named optimally-discriminative voxel-based analysis (ODVBA) was applied to multimodal (structural and DTI) MRI data acquired from 22 treatment-naive ADHD adults and 19 age-and gender-matched healthy controls (HC). Results: Regarding DTI data, we found higher fractional anisotropy in ADHD relative to HC encompassing the white matter (WM) of the bilateral superior frontal gyrus, right middle frontal left gyrus, left postcentral gyrus, bilateral cingulate gyrus, bilateral middle temporal gyrus and right superior temporal gyrus; reductions in trace (a measure of diffusivity) in ADHD relative to HC were also found in fronto-striatal-parieto-occipital circuits, including the right superior frontal gyrus and bilateral middle frontal gyrus, right precentral gyrus, left middle occipital gyrus and bilateral cingulate gyrus, as well as the left body and right splenium of the corpus callosum, right superior corona radiata, and right superior longitudinal and fronto-occipital fasciculi. Volumetric abnormalities in ADHD subjects were found only at a trend level of significance, including reduced gray matter (GM) in the right angular gyrus, and increased GM in the right supplementary motor area and superior frontal gyrus. Conclusions: Our results suggest that adult ADHD is associated with neuroanatomical abnormalities mainly affecting the WM microstructure in fronto-parieto-temporal circuits that have been implicated in cognitive, emotional and visuomotor processes.
- Health-related quality of life in adults with attention-deficit and hyperactivity disorder(2014) SILVA, Maria Aparecida da; CHAIM, Tiffany M.; CAVALETT, Mikael; SERPA, Mauricio H.; ZANETTI, Marcus V.; VIEIRA, Glauco F.; BUSATTO, Geraldo F.; LOUZÃ, Mário R.OBJECTIVE Attention-Deficit and Hyperactivity Disorder is a neurodevelopmental condition that causes substantial deficits in several aspects of human function, resulting in a poor quality of life. However, studies using valid reports to objectively document Quality of Life impairment in never-treated adults with Hyperactivity Disorder Self-Report Scale have, to date, been scarce. The aim of this study was to assess Quality of Life in a clinical sample of treatment-naïve adults with Attention-Deficit and Hyperactivity Disorder in comparison to a healthy control group, and to investigate the relationship between Quality of Life and symptom severity ratings. METHOD Symptom severity ratings (assessed using the Attention-Deficit and Hyperactivity Disorder Self-Report Scale) and quality of life measurements using the World Health Organization Quality of Life scale (through WHOQOL-BREF) were obtained from a sample of 46 treatment-naïve adults with Attention-Deficit and Hyperactivity Disorder (mean age=29.3 years) and a group of 28 healthy controls (mean age=28.7 years). RESULTS Quality of Life was significantly worse in the Attention-deficit and Hyperactivity Disorder group compared to the healthy controls. The severity of symptoms of hyperactivity (but not of inattention) was negatively correlated with quality of life. CONCLUSION The use of a generic Quality of Life tool such as the WHOQOL-BREF allows the detection of lower Quality of Life, vs. healthy controls, in adult Attention-Deficit and Hyperactivity Disorder patients, and highlights the relevance of Quality of Life impairment when planning and monitoring treatment strategies for such a population.