RAFAEL LUCCAS
Índice h a partir de 2011
2
Projetos de Pesquisa
Unidades Organizacionais
LIM/15 - Laboratório de Investigação em Neurologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
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conferenceObject REPETITIVE PERIPHERAL SENSORY STIMULATION AS AN ADD-ON INTERVENTION FOR UPPER LIMB REHABILITATION IN STROKE: A RANDOMIZED TRIAL(2021) CONFORTO, A.; MACHADO, A.; RIBEIRO, N.; PLOW, E.; LIEW, S-L; LEITE, C. Da Costa; ZAVALIANGOS-PETROPULU, A.; MENEZES, I.; ANJOS, S. Dos; LUCCAS, R.; PECKHAM, P.; COHEN, L.- Repetitive Peripheral Sensory Stimulation as an Add-On Intervention for Upper Limb Rehabilitation in Stroke: A Randomized Trial(2021) CONFORTO, Adriana B.; MACHADO, Andre G.; RIBEIRO, Nathalia H. V.; PLOW, Ela B.; LIEW, Sook-Lei; LEITE, Claudia da Costa; ZAVALIANGOS-PETROPULU, Artemis; MENEZES, Isabella; ANJOS, Sarah M. dos; LUCCAS, Rafael; PECKHAM, Paul Hunter; COHEN, Leonardo G.Introduction Repetitive peripheral sensory stimulation (RPSS) followed by 4-hour task-specific training (TST) improves upper limb motor function in subjects with stroke who experience moderate to severe motor upper limb impairments. Here, we compared effects of RPSS vs sham followed by a shorter duration of training in subjects with moderate to severe motor impairments in the chronic phase after stroke. Methods This single-center, randomized, placebo-controlled, parallel-group clinical trial compared effects of 18 sessions of either 1.5 h of active RPSS or sham followed by a supervised session that included 45 min of TST of the paretic upper limb. In both groups, subjects were instructed to perform functional tasks at home, without supervision. The primary outcome measure was the Wolf Motor Function Test (WMFT) after 6 weeks of treatment. Grasp and pinch strength were secondary outcomes. Results In intention-to-treat analysis, WMFT improved significantly in both active and sham groups at 3 and 6 weeks of treatment. Grasp strength improved significantly in the active, but not in the sham group, at 3 and 6 weeks. Pinch strength improved significantly in both groups at 3 weeks, and only in the active group at 6 weeks. Conclusions The between-group difference in changes in WMFT was not statistically significant. Despite the short duration of supervised treatment, WMFT improved significantly in subjects treated with RPSS or sham. These findings are relevant to settings that impose constraints in duration of direct contact between therapists and patients. In addition, RPSS led to significant gains in hand strength. Trial Registry Name: Peripheral Nerve Stimulation and Motor Training in Stroke Clinical Trials.gov identifier: NCT0265878
conferenceObject Peripheral Nerve Stimulation to Enhance Upper Limb Motor Function in Stroke(2019) CONFORTO, Adriana B.; LUCCAS, Rafael; MENEZES, Isabella S.; MACHADO, Andre G.; MELLO, Eduardo A.; ASSIS, Priscila S.; FREITAS, Paloma F.; PIRES, Danielle S.; PECKHAM, Paul H.; COHEN, Leonardo G.- Diffusion Tensor Imaging Biomarkers to Predict Motor Outcomes in Stroke: A Narrative Review(2019) MOURA, Luciana M.; LUCCAS, Rafael; PAIVA, Joselisa P. Q. de; AMARO JR., Edson; LEEMANS, Alexander; LEITE, Claudia da C.; OTADUY, Maria C. G.; CONFORTO, Adriana B.Stroke is a leading cause of disability worldwide. Motor impairments occur in most of the patients with stroke in the acute phase and contribute substantially to disability. Diffusion tensor imaging (DTI) biomarkers such as fractional anisotropy (FA) measured at an early phase after stroke have emerged as potential predictors of motor recovery. In this narrative review, we: (1) review key concepts of diffusion MRI (dMRI); (2) present an overview of state-of-art methodological aspects of data collection, analysis and reporting; and (3) critically review challenges of DTI in stroke as well as results of studies that investigated the correlation between DTI metrics within the corticospinal tract and motor outcomes at different stages after stroke. We reviewed studies published between January, 2008 and December, 2018, that reported correlations between DTI metrics collected within the first 24 h (hyperacute), 2-7 days (acute), and >7-90 days (early subacute) after stroke. Nineteen studies were included. Our review shows that there is no consensus about gold standards for DTI data collection or processing. We found great methodological differences across studies that evaluated DTI metrics within the corticospinal tract. Despite heterogeneity in stroke lesions and analysis approaches, the majority of studies reported significant correlations between DTI biomarkers and motor impairments. It remains to be determined whether DTI results could enhance the predictive value of motor disability models based on clinical and neurophysiological variables.