JAQUELINE HATSUKO TAMASHIRO DURAN
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- PET and SPECT studies of ageing and cardiovascular risk factors for alzheimer’s disease(2014) BUSATTO, G. F.; TAMASHIRO-DURAN, J. H.; ALVES, T. C. De Toledo Ferraz; FERREIRA, L. K.; DURAN, F. L. De SouzaPositron emission tomography (PET) and single-photon emission computerized tomography (SPECT) have been widely used to document local brain metabolism and regional cerebral blood fl ow reductions associated with ageing-related neurodegenerative disorders such as Alzheimer’s disease (AD), the most common form of dementia. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, dyslipidemia, obesity, and smoking, are highly prevalent in the elderly population and have a signifi cant impact on cognitive performance. These conditions are nowadays recognized as important risk factors for AD. In this chapter, we review PET and SPECT studies which have investigated the impact of CVRF on brain functioning and evaluate how such evidence has helped to provide new insights about the pathophysiology of dementing disorders, particularly AD. We also highlight future directions in this fi eld of research, including longitudinal functional imaging studies to document changes in CVRF-related brain hypoactivity patterns, as well as PET studies assessing possible AD-like brain amyloid deposition abnormalities in proportion to the degree of cardiovascular risk in humans. © Springer-Verlag Berlin Heidelberg 2014.
- Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [F-18]Fluorodeoxyglucose-Positron-Emission Tomography Study with Partial Volume Effects Correction(2011) CURIATI, P. K.; TAMASHIRO-DURAN, J. H.; DURAN, F. L. S.; BUCHPIGUEL, C. A.; SQUARZONI, P.; ROMANO, D. C.; VALLADA, H.; MENEZES, P. R.; SCAZUFCA, M.; BUSATTO, G. F.; ALVES, T. C. T. F.BACKGROUND AND PURPOSE: Functional brain variability has been scarcely investigated in cognitively healthy elderly subjects, and it is currently debated whether previous findings of regional metabolic variability are artifacts associated with brain atrophy. The primary purpose of this study was to test whether there is regional cerebral age-related hypometabolism specifically in later stages of life. MATERIALS AND METHODS: MR imaging and FDG-PET data were acquired from 55 cognitively healthy elderly subjects, and voxel-based linear correlations between age and GM volume or regional cerebral metabolism were conducted by using SPM5 in images with and without correction for PVE. To investigate sex-specific differences in the pattern of brain aging, we repeated the above voxelwise calculations after dividing our sample by sex. RESULTS: Our analysis revealed 2 large clusters of age-related metabolic decrease in the overall sample, 1 in the left orbitofrontal cortex and the other in the right temporolimbic region, encompassing the hippocampus, the parahippocampal gyrus, and the amygdala. The division of our sample by sex revealed significant sex-specific age-related metabolic decrease in the left temporolimbic region of men and in the left dorsolateral frontal cortex of women. When we applied atrophy correction to our PET data, none of the above-mentioned correlations remained significant. CONCLUSIONS: Our findings suggest that age-related functional brain variability in cognitively healthy elderly individuals is largely secondary to the degree of regional brain atrophy, and the findings provide support to the notion that appropriate PVE correction is a key tool in neuroimaging investigations.