ANA CLAUDIA LATRONICO XAVIER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Centennial Celebration: Endocrine Reviews Past Highlights for November and December(2016) LATRONICO, Ana Claudia; RICKELS, Michael R.; HANDELSMAN, David J.; SALVATORI, Roberto
- The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty(2023) BRITO, Vinicius N.; CANTON, Ana P. M.; SERAPHIM, Carlos Eduardo; ABREU, Ana Paula; MACEDO, Delanie B.; MENDONCA, Berenice B.; KAISER, Ursula B.; ARGENTE, Jesus; LATRONICO, Ana ClaudiaThe etiology of central precocious puberty (CPP) is multiple and heterogeneous, including congenital and acquired causes that can be associated with structural or functional brain alterations. All causes of CPP culminate in the premature pulsatile secretion of hypothalamic GnRH and, consequently, in the premature reactivation of hypothalamic-pituitary-gonadal axis. The activation of excitatory factors or suppression of inhibitory factors during childhood represent the 2 major mechanisms of CPP, revealing a delicate balance of these opposing neuronal pathways. Hypothalamic hamartoma (HH) is the most well-known congenital cause of CPP with central nervous system abnormalities. Several mechanisms by which hamartoma causes CPP have been proposed, including an anatomical connection to the anterior hypothalamus, autonomous neuroendocrine activity in GnRH neurons, trophic factors secreted by HH, and mechanical pressure applied to the hypothalamus. The importance of genetic and/or epigenetic factors in the underlying mechanisms of CPP has grown significantly in the last decade, as demonstrated by the evidence of genetic abnormalities in hypothalamic structural lesions (eg, hamartomas, gliomas), syndromic disorders associated with CPP (Temple, Prader-Willi, Silver-Russell, and Rett syndromes), and isolated CPP from monogenic defects (MKRN3 and DLK1 loss-of-function mutations). Genetic and epigenetic discoveries involving the etiology of CPP have had influence on the diagnosis and familial counseling providing bases for potential prevention of premature sexual development and new treatment targets in the future. Global preventive actions inducing healthy lifestyle habits and less exposure to endocrine-disrupting chemicals during the lifespan are desirable because they are potentially associated with CPP.
conferenceObject Apparently Sporadic Central Precocious Puberty Is Caused By Paternally Inherited Mutations in the Imprinted MKRN3 Gene(2014) ABREU, Ana Paula; MACEDO, Delanie B.; REIS, Ana Claudia Silva; MONTENEGRO, Luciana Ribeiro; DAUBER, Andrew; BENEDUZZI, Diane; CULIER, Priscilla; SILVEIRA, Leticia Gontijo; TELES, Milena Gurgel; CARROLL, Rona S.; GUERRA, Gil; GUARAGNA FILHO, Guilherme; GUCEV, Zoran Spasico; ARNHOLD, Ivo J. P.; CASTRO, Margaret; MOREIRA, Ayrton Custodio; MARTINELLI, Carlos Eduardo; HIRSCHHORN, Joel N.; MENDONASA, Berenice Bilharinho; BRITO, Vinicius N.; ANTONINI, Sonir Roberto; KAISER, Ursula B.; LATRONICO, Ana ClaudiaconferenceObject Development of Virilizing Adrenocortical Carcinoma during Pregnancy: Case Report(2014) NAKAGUMA, Marilena; MINANNI, Carlos Andre; MIRANDA, Mirela Costa de; LERARIO, Antonio M.; MENDONCA, Berenice B.; LATRONICO, Ana Claudia; ALMEIDA, Madson Q.; FRAGOSO, Maria Candida B. V.conferenceObject Mutation and Expression Analysis of DICER1 and Mir-103 in Pediatric and Adult Adrenocortical Tumors(2014) SOUSA, Gabriela R. V.; RIBEIRO, Tamaya C.; FARIA, Andre M.; MARIANI, Beatriz M. P.; LERARIO, Antonio M.; ZERBINI, Maria Claudia N.; SOARES, Ibere C.; WAKAMATSU, Alda; ALVES, Venancio A. F.; MENDONCA, Berenice B.; FRAGOSO, Maria Candida B. V.; LATRONICO, Ana Claudia; ALMEIDA, Madson Q.conferenceObject Deciphering the Functional Mechanisms By Which MKRN3 Regulates Puberty Initiation(2014) ABREU, Ana Paula; NAVARRO, Victor Manuel; BOSCH, Martha A.; LIANG, Joy N.; MACEDO, Delanie B.; SIMAVLI, Serap; NOEL, Sekoni D.; THOMPSON, Iain Robert; CARROLL, Rona S.; RONNEKLEIV, Oline K.; LATRONICO, Ana Claudia; KAISER, Ursula B.conferenceObject The Specific p.R337H TP53 Germline Mutation in Adults with Adrenocortical Carcinoma(2014) GRUETZMACHER, Christiane; NAKAGUMA, Marilena; MIRANDA, Mirela Costa de; MERMEJO, Livia Mara; CASTRO, Margaret; RESENDE, Gabriela; LERARIO, Antonio M.; MENDONCA, Berenice B.; LATRONICO, Ana Claudia; ANTONINI, Sonir Roberto; ALMEIDA, Madson Q.; FRAGOSO, Maria Candida B. V.conferenceObject Amplification of the Insulin-like Growth Factor 1 Receptor Gene in an Adrenocortical Adenocarcinoma: Searching for Potential Mechanisms of Overexpression(2014) RIBEIRO, Tamaya C.; JORGE, Alexander Augusto Lima; ALMEIDA, Madson Q.; MARIANI, Beatriz M. P.; NISHI, Mirian Yumie; MENDONCA, Berenice B.; FRAGOSO, Maria Candida Barisson Villares; LATRONICO, Ana ClaudiaconferenceObject Transcriptomic Response to Calcitriol in Human Fibroblasts with or without a Functional Vitamin D Receptor(2014) FERRAZ-DE-SOUZA, Bruno; KATAYAMA, Maria L.; FOLGUEIRA, Maria A. K.; CORREA, Pedro Henrique S.; LATRONICO, Ana Claudia; MARTIN, Regina M.