ALEXANDRE FERREIRA RAMOS
Projetos de Pesquisa
Unidades Organizacionais
SIN-86, EACH - Docente
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Lessons and perspectives for applications of stochastic models in biological and cancer research(2018) SABINO, Alan U.; VASCONCELOS, Miguel Fs; SITTONI, Misaki Yamada; LAUTENSCHLAGER, Willian W.; QUEIROGA, Alexandre S.; MORAIS, Mauro Cc; RAMOS, Alexandre F.The effects of randomness, an unavoidable feature of intracellular environments, are observed at higher hierarchical levels of living matter organization, such as cells, tissues, and organisms. Additionally, the many compounds interacting as a well-orchestrated network of reactions increase the difficulties of assessing these systems using only experiments. This limitation indicates that elucidation of the dynamics of biological systems is a complex task that will benefit from the establishment of principles to help describe, categorize, and predict the behavior of these systems. The theoretical machinery already available, or ones to be discovered to help solve biological problems, might play an important role in these processes. Here, we demonstrate the application of theoretical tools by discussing some biological problems that we have approached mathematically: fluctuations in gene expression and cell proliferation in the context of loss of contact inhibition. We discuss the methods that have been employed to provide the reader with a biologically motivated phenomenological perspective of the use of theoretical methods. Finally, we end this review with a discussion of new research perspectives motivated by our results.
- Symmetry-guided design of topologies for supercomputer networks(2018) SABINO, Alan U.; VASCONCELOS, Miguel F. S.; DENG, Yuefan; RAMOS, Alexandre F.A family of graphs optimized as the topologies for interconnection networks is proposed. The needs of such topologies with minimal diameters and minimal mean path lengths are met by special constructions of the weight vectors in a representation of the symplectic algebra. Such design of topologies can conveniently reconstruct the mesh and hypercube, widely used as network topologies, as well as many other classes of graphs potentially suitable for network topologies.
conferenceObject Stochastic model of contact inhibition and the proliferation of melanoma in situ.(2018) MORAIS, Mauro Cesar C.; STUHL, Izabella; SABINO, Alan U.; LAUTENSCHLAGER, Willian W.; QUEIROGA, Alexandre S.; TORTELLI JR., Tharcisio C.; CHAMMAS, Roger; SUHOV, Yuri; RAMOS, Alexandre F.conferenceObject Evaluation of the functional role and the potential prognostic value of the members of the PHLDA family (pleckstrin homology-like domain family A) using data mining.(2018) VALOYES, Maira Andrea; RAMOS, Alexandre; NAGAI, Maria AparecidaconferenceObject GD3 ganglioside-enriched extracellular vesicles stimulate melanocyte migration(2018) OTAKE, Andreia H.; DUARTE, Ana Paula M.; SAITO, Renata de Freitas; RAMOS, Alexandre F.; CHAMMAS, Roger