RONALDO ADIB KAIRALLA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
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conferenceObject Radiographic Fibrosis Is Associated with Accelerated Lung Function Decline in Patients with Hypersensitivity Pneumonitis(2020) KAWANO-DOURADO, L. C.; ARIMURA, F. E.; RODRIGUES, S. C.; SPONHOLZ, M.; LIMA, M. S.; BEDER, T.; STORRER, K. M.; SAWAMURA, M.; CATUNDA, L. G.; CARVALHO, A. Castro De; SANTOS, P. C. C.; BASILIO, C. C.; SANCHEZ, G. J. S.; NAKAGAWA, R. H.; MONTEIRO, J. T. C.; SANTOS, R. K.; PINHEIRO, M. F. S.; CUNHA, T. M.; JOHANNSON, K. A.; KAIRALLA, R. A.- Mechanisms of Exercise Limitation and Prevalence of Pulmonary Hypertension in Pulmonary Langerhans Cell Histiocytosis(2020) HEIDEN, Glaucia Itamaro; SOBRAL, Juliana Barbosa; FREITAS, Carolina Salim Goncalves; ALBUQUERQUE, Andre Luis Pereira de; SALGE, Joao Marcos; KAIRALLA, Ronaldo Adib; FERNANDES, Caio Julio Cesar dos Santos; CARVALHO, Carlos Roberto Ribeiro; SOUZA, Rogerio; BALDI, Bruno GuedesBACKGROUND: Pulmonary Langerhans cell histiocytosis (PLCH) determines reduced exercise capacity. The speculated mechanisms of exercise impairment in PLCH are ventilatory and cardiocirculatory limitations, including pulmonary hypertension (PH). RESEARCH QUESTION: What are the mechanisms of exercise limitation, the exercise capacity , and the prevalence of dynamic hyperinflation (DH) and PH in PLCH? STUDY DESIGN AND METHODS: In a cross-sectional study, patients with PLCH underwent an incremental treadmill cardiopulmonary exercise test with an evaluation of DH, pulmonary function tests, and transthoracic echocardiography. Those patients with lung diffusing capacity for carbon monoxide (D-LCO) < 40% predicted and/or transthoracic echocardiogram with tricuspid regurgitation velocity > 2.5 m/s and/or with indirect PH signs underwent right heart catheterization. RESULTS: Thirty-five patients were included (68% women; mean age, 47 +/- 11 years). Ventilatory and cardiocirculatory limitations, impairment suggestive of PH, and impaired gas exchange occurred in 88%, 67%, 29%, and 88% of patients, respectively. The limitation was multifactorial in 71%, exercise capacity was reduced in 71%, and DH occurred in 68% of patients. FEV1 and D-LCO were 64 +/- 22% predicted and 56 +/- 21% predicted. Reduction in D-LCO, an obstructive pattern, and air trapping occurred in 80%, 77%, and 37% of patients. FEV1 and D-LCO were good predictors of exercise capacity. The prevalence of PH was 41%, predominantly with a precapillary pattern, and mean pulmonary artery pressure correlated best with FEV1 and tricuspid regurgitation velocity. INTERPRETATION: PH is frequent and exercise impairment is common and multifactorial in PLCH. The most prevalent mechanisms are ventilatory, cardiocirculatory, and suggestive of PH limitations.
conferenceObject Radiation Pneumonitis in Patients with Interstitial Lung Disease and Lung Cancer: Report of 6 Cases(2020) FREITAS, L. V. de; SERRA, J. P.; NAJAS, G. F.; PRADO, G. F.; KAWASSAKI, A. M.; TAKAGAKI, T. Y.; GABRIELLI, F.; JUNIOR, G. C.; OLIVEIRA, M. R.; KAIRALLA, R. A.; BALDI, B. G.conferenceObject Primary Lung Fibrous Histiocytoma Presenting as Diffuse Pulmonary Cystic Disease(2020) MAIA, A. P.; MARTIN, S. R. San; BRIDI, G. P.; BEDER, T. N.; COLARES, P. F.; HOLZ, I. M.; SERRA, J. P.; NASCIMENTO, E. C. T.; LIMA, L. G. C. A.; AMARAL, A. F.; OLIVEIRA, M. R.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject Anti-Synthetase Syndrome After Exposure 3D Ink: Case Report(2020) BRIDI, G. D.; CARRANZA, M. X. M.; MARIN, P. J. Q.; PARENTE, Y. D. M.; SILVA, N. F. da; HOLZ, I.; SERRA, J. P.; COLARES, P. F.; BEDER, T. N.; COSTA, F. M. da; KAIRALLA, R. A.- COVID-19 and lymphangioleiomyomatosis: Experience at a reference center and the potential impact of the use ofmTORinhibitors(2020) BALDI, Bruno Guedes; AMARAL, Alexandre Franco; COLARES, Phillipe de Figueiredo Braga; KAIRALLA, Ronaldo Adib; OLIVEIRA, Martina Rodrigues de; CARVALHO, Carlos Roberto Ribeiro
conferenceObject ARDS in a Patient Whit Sarcoidosis: A Diagnostic Challenge(2020) SILVA, N. F.; PROVENCI, B.; MARTIN, S. R. San; BEDER, T. N.; COLARES, P. F.; HOLZ, I. M.; SERRA, J. P.; AMARAL, A. F.; ARIMURA, F. E.; BALDI, B. G.; KAIRALLA, R. A.conferenceObject Rheumatoid Arthritis Associated Interstitial Lung Disease: The Progressive Phenotype Is Associated with Recurrent Infection Episodes(2020) SERRA, J. P.; MOLINA, C. de Assis; SABBAG, M. L.; RANGEL, D. A. D.; BONFIGLIOLI, K.; SAWAMURA, M.; NAKAGAWA, R. H.; KAIRALLA, R. A.; KAWANO-DOURADO, L.- Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis(2020) KAWANO-DOURADO, Leticia; DOYLE, Tracy J.; BONFIGLIOLI, Karina; SAWAMURA, Marcio V. Y.; NAKAGAWA, Renato H.; ARIMURA, Fabio E.; LEE, Hye J.; RANGEL, Diana Arrais de Souza; BUENO, Cleonice; CARVALHO, Carlos R. R.; SABBAG, Maria Laura; MOLINA, Camila; ROSAS, Ivan O.; KAIRALLA, Ronaldo A.BACKGROUND Interstitial lung abnormalities (ILA) and interstitial lung disease (ILD) are seen in up to 60% of individuals with rheumatoid arthritis (RA), some of which will progress to have a significant impact on morbidity and mortality rates. Better characterization of progressive interstitial changes and identification of risk factors that are associated with progression may enable earlier intervention and improved outcomes. RESEARCH QUESTION. What are baseline characteristics associated with RA-ILD progression? STUDY DESIGN AND METHOD! We performed a retrospective study in which all clinically indicated CT chest scans in adult individuals with RA from 2014 to 2016 were evaluated for interstitial changes, and the data were further subdivided into ILA and ILD based on clinical record review. Progression was determined visually and subsequently semiquantified. RESULTS. Those individuals with a spectrum of interstitial changes (64 of 293) were older male smokers and less likely to be receiving biologics/small molecule disease-modifying antirheumatic drugs. Of 44% of the individuals with ILA, 46% had had chest CT scans performed for nonpulmonary indications. Of the 56 individuals with ILA/ILD with sequential CT scans, 38% had evidence of radiologic progression over 4.4 years; 29% of of individuals with ILA progressed. Risk factors for progressive ILA/ILD included a subpleural distribution and higher baseline involvement. INTERPRETATION. Of 293 individuals with RA with clinically indicated CT scans, interstitial changes were observed in 22%, one-half of whom had had a respiratory complaint at the time of imaging; radiologic progression was seen in 38%. Of individuals with progressive ILA, one-half had had baseline CT scans performed for nonpulmonary indications. Subpleural distribution and higher baseline ILA/ILD extent were risk factors associated with progression. Prospective longi- tudinal studies of RA-ILA are necessary.
conferenceObject Metastatic Pulmonary Calcification in a Patient with Chronic Kidney Disease: Case Report(2020) BRIDI, G. D.; MAIA, A. P.; MARTIN, S. R. San; VASCONCELOS, A. P.; HOLZ, I.; SERRA, J. P.; BEDER, T. N.; COLARES, P. F.; BERNARDI, F. D.; COSTA, F. M. da; KAIRALLA, R. A.