NAOMI KONDO NAKAGAWA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina - Docente
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
LIM/54 - Laboratório de Bacteriologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Pentoxifylline attenuates leukocyte-endothelial interactions in a two-hit model of shock and sepsis(2015) NAKAGAWA, Naomi Kondo; CRUZ JR., Ruy J.; AIKAWA, Priscila; CORREIA, Cristiano J.; CRUZ, Jose Walber Miranda Costa; MAUAD, Thais; ZHANG, Haibo; ROCHA-E-SILVA, Mauricio; SANNOMIYA, PaulinaBackground: This study investigated the effects of pentoxifylline (PTX) combined with resuscitation fluids on microcirculatory dysfunctions in a two-hit model of shock and sepsis. Materials and methods: Male Wistar rats (250 g) were submitted to hemorrhagic shock and reperfusion followed by sepsis induced by cecal ligation and puncture. For the initial treatment of shock, rats were randomly divided into: sham, no injury, no treatment; hypertonic saline solution (HS) (7.5%, 4 mL/kg); lactated Ringer's solution (LR, 3 x shed blood volume); HS + PTX (4 mL/Kg + 25 mg/kg PTX); and LR + PTX (3 x shed blood volume = 25 mg/kg PTX). After 48 h of being exposed to the double injury, leukocyte eendothelial interactions were assessed by intravital microscopy of the mesentery. Endothelial expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) was evaluated by immunohistochemistry, as well as lung neutrophil infiltration by histology. Results: Lactated Ringer's solution induced marked increases (P < 0.001) in the number of rolling leukocytes per 10 min (two-fold), adherent leukocytes per 100 mu m venule length (sixfold), migrated leukocytes per 5000 mu m(2) (eight-fold), P-selectin and ICAM-1 expression (four-fold), and lung neutrophil infiltration (three-fold) compared with sham. In contrast, PTX attenuated leukocyte-endothelial interactions, P-selectin and ICAM-1 expression at the mesentery when associated with either LR (P < 0.001) or HS (P < 0.05). Neutrophil migration into the lungs was similarly reduced by PTX (P < 0.05). Conclusions: Data presented showed thatpentoxifylline attenuates microcirculatory disturbances at the mesenteric bed with significant minimization of lung inflammation after a double-injury model of hemorrhagicshock and reperfusion followed by sepsis.
- Up to 206 Million People Reached and Over 5.4 Million Trained in Cardiopulmonary Resuscitation Worldwide: The 2019 International Liaison Committee on Resuscitation World Restart a Heart Initiative(2020) BOETTIGER, Bernd W.; LOCKEY, Andrew; AICKIN, Richard; CARMONA, Maria; CASSAN, Pascal; CASTREN, Maaret; RAO, S. S. C. Chakra; CAEN, Allan De; ESCALANTE, Raffo; GEORGIOU, Marios; HOOVER, Amber; KERN, Karl B.; KHAN, Abdul Majeed S.; LEVI, Cianna; LIM, Swee H.; NADKARNI, Vinay; NAKAGAWA, Naomi V.; NATION, Kevin; NEUMAR, Robert W.; NOLAN, Jerry P.; MELLIN-OLSEN, Jannicke; PAGANI, Jacopo; SALES, Monica; SEMERARO, Federico; STANTON, David; TOPORAS, Cristina; GROOTVEN, Heleen van; WANG, Tzong-Luen; WIJESURIYA, Nilmini; WONG, Gillian; PERKINS, Gavin D.Sudden out-of-hospital cardiac arrest is the third leading cause of death in industrialized nations. Many of these lives could be saved if bystander cardiopulmonary resuscitation rates were better. ""All citizens of the world can save a life-CHECK-CALL-COMPRESS."" With these words, the International Liaison Committee on Resuscitation launched the 2019 global ""World Restart a Heart"" initiative to increase public awareness and improve the rates of bystander cardiopulmonary resuscitation and overall survival for millions of victims of cardiac arrest globally. All participating organizations were asked to train and to report the numbers of people trained and reached. Overall, social media impact and awareness reached up to 206 million people, and >5.4 million people were trained in cardiopulmonary resuscitation worldwide in 2019. Tool kits and information packs were circulated to 194 countries worldwide. Our simple and unified global message, ""CHECK-CALL-COMPRESS,"" will save hundreds of thousands of lives worldwide and will further enable many policy makers around the world to take immediate and sustainable action in this most important healthcare issue and initiative.
- Effectiveness of the 40-Minute Handmade Manikin Program to Teach Hands-on Cardiopulmonary Resuscitation at School Communities(2021) NAKAGAWA, Naomi K.; OLIVEIRA, Katia M. G.; LOCKEY, Andrew; SEMERARO, Federico; AIKAWA, Priscila; MACCHIONE, Mariangela; CARVALHO-OLIVEIRA, Regiani; GOUVEA, Gabriela B.; BOAVENTURA, Ana Paula; I, Adalgisa Maiworm; CALDERARO, Marcelo; HAJJAR, Ludhmila A.; V, Eduardo Motta; SOUZA, Heraldo P.; ANDRE, Carmen D. S. de; SILVA, Luiz F. F.; POLASTRI, Thatiane F.; TIMERMAN, Sergio; CARMONA, Maria Jose C.; BOETTIGER, Bernd W.Bystander training in cardiopulmonary resuscitation (CPR) is crucial to improve the victims' survival and quality of life after sudden cardiac arrest. This observational study aimed to determine the success rate of 2 different programs of CPR training for children, adolescents, and adults in school communities. We assessed the development and acquisition of the following CPR skills checking local safety, assessing victim's responsiveness, calling for help, assessing victim's breathing, and performing chest compression (hands and straight arms placement on the chest, compression velocity, depth, and chest release) using a 40-minute program with handmade manikins or the 120-minute program using intermediate-fidelity manikins. There were 1,630 learners (mean age 16 years, 38% male) in the 40-minute program, and 347 learners (mean age 27 years, 32% male) in the 120-minute program. The lowest successful pass rate of learners that developed CPR skills was 89.4% in the 40-minute program and 84.5% in the 120-minute program. The chances of success increased with age in the same program (compression rate and depth). The success rate also increased with the more extended and intermediate-cost program at the same age (assessing victim's responsiveness, calling for help, and assessing the victim's respiration). In conclusion, a 40-minute and cheaper (low-cost handmade manikin) CPR program was adequate to develop and acquire the overall CPR skills for >= 89% at school communities, independently of gender. However, some individual CPR skills can be further improved with increasing age and using the longer and intermediate-cost program.
- The Effects of Low and High Tidal Volume and Pentoxifylline on Intestinal Blood Flow and Leukocyte-Endothelial Interactions in Mechanically Ventilated Rats(2011) AIKAWA, Priscila; ZHANG, Haibo; BARBAS, Carmen S. V.; PAZETTI, Rogerio; CORREIA, Cristiano; MAUAD, Thais; SILVA, Eliezer; SANNOMIYA, Paulina; POLI-DE-FIGUEIREDO, Luiz F.; NAKAGAWA, Naomi KondoBACKGROUND: The combination of high PEEP and low tidal volume (V(T)) decreases some risks of mechanical ventilation, including pulmonary overdistention, damage due to cyclic opening and closing of the alveoli, and inflammatory responses that can lead to multiple-organ dysfunction. We hypothesized that high V(T) and high PEEP induce mesenteric microcirculatory disturbances and that those disturbances would be attenuated by pentoxifylline, which is anti-inflammatory. METHODS: We anesthetized (isoflurane 1.5%), tracheostomized, and mechanically ventilated 57 male Wistar rats with PEEP of 10 cm H(2)O and F(IO2) of 0.21 for 2 hours. One group received low V(T) (7 mL/kg), another group received high V(T) (10 mL/kg), and a third group received high V(T) plus pentoxifylline (25 mg/kg). We measured mean arterial pressure, respiratory mechanics, mesenteric blood flow, and leukocyte-endothelial interactions. RESULTS: The mean arterial pressure was similar among the groups at baseline (108 mm Hg [IQR 94-118 mm Hg]) and after 2 hours of mechanical ventilation (104 mm Hg [IQR 90-114 mm Hg]). Mesenteric blood flow was also similar between the groups: low V(T) 15.1 mL/min (IQR 12.4-17.7 mL/min), high V(T) 11.3 mL/min (IQR 8.6-13.8 mL/min), high-V(T)/pentoxifylline 12.4 mL/min (10.8-13.7 mL/min). Peak airway pressure after 2 hours was lower (P = .03) in the low-V(T) group (10.4 cm H(2)O [IQR 10.2-10.4 cm H(2)O]) than in the high-V(T) group (12.6 cm H(2)O [10.2-14.9 cm H(2)O]) or the high-V(T)/pentoxifylline group (12.8 cm H(2)O [10.7-16.0 cm H(2)O]). There were fewer adherent leukocytes (P = .005) and fewer migrated leukocytes (P = .002) in the low-V(T) group (5 cells/100 gm length [IQR 4-7 cells/100 mu m length] and 1 cell/5,000 mu m(2) [IQR 1-2 cells/5,000 mu m(2)], respectively) and the high-V(T)/pentoxifylline group (5 cells/100 mu m length [IQR 3-10 cells/100 mu m length] and 1 cell/5,000 mu m(2) [IQR 1-3 cells/5,000 mu m(2)], respectively) than in the high-V(T) group (14 cells/100 mu m length [IQR 11-16 cells/100 mu m length] and 9 cells/5,000 mu m(2) [IQR 8-12 cells/5,000 mu m(2)], respectively). CONCLUSIONS: Low V(T) with high PEEP was lung-protective, and early pentoxifylline reduced the inflammatory response to high V(T) with high PEEP (and presumed lung overdistention) during mechanical ventilation.
- World Restart a Heart 2020: How to keep a life-saving awareness campaign alive in a pandemic(2021) ROTT, Nadine; LOCKEY, Andrew; BOETTIGER, Bernd W.; BOUCIF, Salome; CARMONA, Maria; CASSAN, Pascal; RAO, Siddha S. C. Chakra; ESCALANTE-KANASHIRO, Raffo; GARG, Rakesh; GEORGIOU, Marios; HOOVER, Amber V.; KHAN, Abdulmajeed; LEVI, Cianna; LIM, Swee Han; MAHAJAN, Hitendra Chandrakant; MEAR, Teghan; MONSIEURS, Koenraad; NADKARNI, Vinay; NAKAGAWA, Naomi Kondo; NATION, Kevin; NEUMAR, Robert; O'SHAUGHNESSY, Krista; SALES, Monica; SEMERARO, Federico; GROOTVEN, Heleen Van; WANG, Tzong-Luen; WIJESURIYA, Nilmini
- KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation(2023) SCHROEDER, Daniel C.; SEMERARO, Federico; GREIF, Robert; BRAY, Janet; MORLEY, Peter; PARR, Michael; NAKAGAWA, Naomi Kondo; IWAMI, Taku; FINKE, Simon-Richard; HANSEN, Carolina Malta; LOCKEY, Andrew; RIOS, Marina Del; BHANJI, Farhan; SASSON, Comilla; SCHEXNAYDER, Stephen M.; SCQUIZZATO, Tommaso; WETSCH, Wolfgang A.; BOETTIGER, Bernd W.; International Liaison Committee ResuscitationBACKGROUND: Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best practices to provide basic life METHODS: After topics and subgroups were defined, a comprehensive literature search was conducted. Systematic reviews and controlled and uncontrolled prospective and retrospective studies containing data on students <20 years of age were included. RESULTS: Schoolchildren are highly motivated to learn basic life support. The CHECK-CALL-COMPRESS algorithm is recommended for all schoolchildren. Regular training in basic life support regardless of age consolidates long-term skills. Young children from 4 years of age are able to assess the first links in the chain of survival. By 10 to 12 years of age, effective chest compression depths and ventilation volumes can be achieved on training manikins. A combination of theoretical and practical training is recommended. Schoolteachers serve as effective basic life support instructors. Schoolchildren also serve as multipliers by passing on basic life support skills to others. The use of age-appropriate social media tools for teaching is a promising approach for schoolchildren of all ages. CONCLUSIONS: Schoolchildren basic life support training has the potential to educate whole generations to respond to cardiac arrest and to increase survival after out-of-hospital cardiac arrest. Comprehensive legislation, curricula, and scientific assessment are crucial to further develop the education of schoolchildren in basic life support.