PROTASIO LEMOS DA LUZ
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
conferenceObject Additive effects of exercise training upon cognitive function in regular red wine consumers compared to abstainers(2019) NISHIYAMA, M.; CAMPANE, L. Z.; NUCCI, M. P.; ZUBEN, M. V.; TROMBETTA, I. C.; RONDON, E.; NEGRAO, C. E.; JUNIOR, E. A.; LAURINDO, F. R. M.; LUZ, P. L. Da- Cardioprotection conferred by exercise training is blunted by blockade of the opioid system(2011) GALVAO, Tatiana F. G.; MATOS, Katt C.; BRUM, Patricia C.; NEGRAO, Carlos E.; LUZ, Protasio Lemos da; CHAGAS, Antonio Carlos P.OBJECTIVES: To investigate the effect of opioid receptor blockade on the myocardial protection conferred by chronic exercise and to compare exercise training with different strategies of myocardial protection (opioid infusion and brief periods of ischemia-reperfusion) preceding irreversible left anterior descending coronary ligation. INTRODUCTION: The acute cardioprotective effects of exercise training are at least partly mediated through opioid receptor-dependent mechanisms in ischemia-reperfusion models. METHODS: Male Wistar rats (n = 76) were randomly assigned to 7 groups: (1) control; (2) exercise training; (3) morphine; (4) intermittent ischemia-reperfusion (three alternating periods of left anterior descending coronary occlusion and reperfusion); (5) exercise training+morphine; (6) naloxone (a non-selective opioid receptor blocker) plus morphine; (7) naloxone before each exercise-training session. Myocardial infarction was established in all groups by left anterior descending coronary ligation. Exercise training was performed on a treadmill for 60 minutes, 5 times/week, for 12 weeks, at 60% peak oxygen (peak VO(2)). Infarct size was histologically evaluated. RESULTS: Exercise training significantly increased exercise capacity and Delta VO(2) (VO(2) peak - VO(2) rest) (p < 0.01 vs. sedentary groups). Compared with control, all treatment groups except morphine plus naloxone and exercise training plus naloxone showed a smaller infarcted area (p < 0.05). No additional decrease in infarct size occurred in the exercise training plus morphine group. No difference in myocardial capillary density (p = 0.88) was observed in any group. CONCLUSIONS: Exercise training, morphine, exercise training plus morphine and ischemia-reperfusion groups had a smaller infarcted area than the control group. The effect of chronic exercise training in decreasing infarct size seems to occur, at least in part, through the opioid receptor stimulus and not by increasing myocardial perfusion.
- Effect of Exercise Training on Plasma Levels and Functional Properties of High-Density Lipoprotein Cholesterol in the Metabolic Syndrome(2011) CASELLA-FILHO, Antonio; CHAGAS, Antonio Carlos P.; MARANHAO, Raul C.; TROMBETTA, Ivani C.; CESENA, Fernando H. Y.; SILVA, Vanessa M.; TANUS-SANTOS, Jose Eduardo; NEGRAO, Carlos E.; LUZ, Protasio L. daIntense lifestyle modifications can change the high-density lipoprotein (HDL) cholesterol concentration. The aim of the present study was to analyze the early effects of short-term exercise training, without any specific diet, on the HDL cholesterol plasma levels and HDL functional characteristics in patients with the metabolic syndrome (MS). We studied 30 sedentary subjects, 20 with and 10 without the MS. The patients with the MS underwent moderate intensity exercise training for 3 months on bicycle ergometers. Blood was sampled before and after training for biochemical analysis, paraoxonase-1 activity, and HDL subfraction composition and antioxidative capacity. Lipid transfer to HDL was assayed in vitro using a labeled nanoemulsion as the lipid donor. At baseline, the MS group had greater triglyceride levels and a lower HDL cholesterol concentration and lower paraoxonase-1 activity than did the controls. Training decreased the plasma triglycerides but did not change the low-density lipoprotein or HDL cholesterol levels. Nonetheless, exercise training increased the HDL subfractions' antioxidative capacity and paraoxonase-1 activity. After training, the MS group had compositional changes in the smallest HDL subfractions associated with increased free cholesterol and cholesterol ester transfers to HDL, reaching normal values. In conclusion, the present investigation has added relevant information about the dissociation between the quantitative and qualitative aspects of HDL after short-term exercise training without any specific diet in those with the MS, highlighting the importance of evaluating the functional aspects of the lipoproteins, in addition to their plasma levels.
conferenceObject Influence of O2 consumption upon cerebral function during operational memory task in red wine drinkers and abstainers subjected to exercise training: a study by functional magnetic resonance(2016) NISHIYAMA, M.; CAMPANE, L. Z.; NUCCI, M. P.; LAURINDO, F. R. M.; FAVARATO, D.; ZUBEN, M. Von; ROCHA, J. P.; TROMBETTA, I. C.; RONDON, E.; GATTAZ, W. F.; NEGRAO, C. E.; AMARO JR., E.; LUZ, P. L. Da