VIVIAN REGINA GUZELA
Projetos de Pesquisa
Unidades Organizacionais
LIM/35 - Laboratório de Nutrição e Cirurgia Metabólica do Aparelho Digestivo, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
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conferenceObject Prevalence association between HPV and fistulising perianal Crohn's disease(2020) BOARINI, L. Rodrigues; SOBRADO JR., C. W.; GUZELA, V. R.; GONCALVES, A. Pozzebon; VILLA, L. Lina; NADAL, S. R.; COSTA, A. Da Costa Lino; NAHAS, S. C.- Anorectal Mucosal Melanoma: A Case Report and Literature Review(2021) JUNIOR, Jose Donizeti de Meira; SOBRADO, Lucas Faraco; GUZELA, Vivian M.; NAHAS, Sergio Carlos; SOBRADO, Carlos WalterObjective: Rare disease Background: Anorectal mucosal melanoma (AMM) is a rare and aggressive neoplasm, with a 5-year survival rate of 10%. Due to its rarity and nonspecific symptoms, the diagnosis is often made late. Surgical resection remains the criterion standard for treatment of anorectal melanoma. Case Report: We present the case of an 81-year-old woman presenting with hematochezia, anal secretion, tenesmus, difficulty in defecation, and perianal pain. On physical examination, there was a prolapse of a 5-cm melanocytic nodule in the anal canal, hard on palpation. Biopsy confirmed anorectal melanoma. Staging revealed anal and metastatic disease, with adrenal, lymphatic, and hepatic involvement. As the patient continued to have bleeding, severe pain, and difficulty in defecation, she was submitted to a wide local excision. At 5-month followup, the anal lesion had relapsed, and the patient died 10 months after the procedure. Conclusions: AMM is a rare and extremely aggressive tumor. Symptoms are nonspecific but early diagnosis should be pursued to allow curative treatment. Surgical resection with free margins is the goal of surgical treatment. New therapies are being studied, including immunotherapy, which can improve the dismal prognosis of this rare disease.
conferenceObject Infection of the anal canal by human papillomavirus in Crohn's disease(2020) GUZELA, V.; SOBRADO JUNIOR, C.; NADAL, S.; NADAL, C. R.; VILLA, L. L.; GONCALVES, A. P.; BOARINI, L. R.; NAHAS, S. C.; CECCONELLO, I.