BEATRIZ MANGUEIRA SARAIVA RAMANHOLO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
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conferenceObject Sometimes Less Is More: A Compare Between Two Models Of Cigarette Smoke Co-Exposition In Ova-Sensitized Mice(2014) ARANTES-COSTA, F. M.; BRUGGEMANN, T. R.; FERNANDES, P.; OLIVEIRA, J. M. S.; SARAIVA-ROMANHOLO, B. M.; MARTINS, M. A.conferenceObject Effect Of Proteinase Inhibitor Of Plant Origin Cratabl In An Experimental Model Of Chronic Allergic Pulmonary Inflammation(2014) SANTOS, A. S. A. Dos; RODRIGUES, A. P. D.; ARANTES-COSTA, F. M.; SARAIVA-ROMANHOLO, B. M.; FILHO, G. G. N.; LEICK, E. A.; MARTINS, M. A.; TIBERIO, I. D. F. L. C.conferenceObject A compare between two models of cigare tie smoke co-exposition in ovalbumin-sensitized mice(2014) BRUGGEMANN, Thayse Regina; FERNANDES, Paula; OLIVEIRA, Jessica Marques Saez; SARAIVA-ROMANHOLO, Beatriz Mangueira; MARTINS, Milton Arruda; ARANTES-COSTA, Fernanda MagalhaesconferenceObject Lung inflammation was attenuated by sakuranetin treatment in a model of acute lung injury(2014) MERNAK, Marcia; SANTANA, Fernanda; PINHEIRO, Nathalia; SARAIVA-RAMANHOLO, Beatriz; GRECCO, Simone; TIBERIO, Iolanda; MARTINS, Milton; LAGO, Joao; PRADO, CarlaconferenceObject Aerobic training decrease bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: A randomized controlled trial(2014) CARVALHO, Celso R. F.; FRANCA-PINTO, Andrezza; MENDES, Felipe A. R.; STELMACH, Rafael; CUKIER, Alberto; AGONDI, Rosana C.; MARTINS, Milton A.; SARAIVA-ROMANHOLO, Beatriz M.; KALIL, Jorge; GIAVINA-BIANCHI, PedroconferenceObject Essential oils reduced lung inflammation in a model of acute lung injury(2014) GUERREIRO, Marina; MERNAK, Marcia; SANTANA, Fernanda; PINHEIRO, Nathalia; SARAIVA-RAMANHOLO, Beatriz; CAPELLO, Tabata; TIBERIO, Iolanda; MARTINS, Milton; LAGO, Joao; PRADO, Carla- Acute cardiopulmonary effects induced by the inhalation of concentrated ambient particles during seasonal variation in the city of Sao Paulo(2014) BRITO, Jose Mara de; MACCHIONE, Mariangela; YOSHIZAKI, Kelly; TOLEDO-ARRUDA, Alessandra Choqueta; SARAIVA-ROMANHOLO, Beatriz Mangueira; ANDRADE, Maria de Fatima; MAUAD, Thais; RIVERO, Dolores Helena Rodriguez Ferreira; SALDIVA, Paulo Hilario NascimentoAmbient particles may undergo modifications to their chemical composition as a consequence of climatic variability. The determination of whether these changes modify the toxicity of the particles is important for the understanding of the health effects associated with particle exposure. The objectives were to determine whether low levels of particles promote cardiopulmonary effects, and to assess if the observed alterations are influenced by season. Mice were exposed to 200 mu g/m(3) concentrated ambient particles (CAPs) and filtered air (FA) in cold/dry and warm/humid periods. Lung hyperresponsiveness, heart rate, heart rate variability, and blood pressure were evaluated 30 min after each exposure. After 24 h, blood and tissue samples were collected. During both periods (warm/humid and cold/dry), CAPs induced alterations in red blood cells and lung inflammation. During the cold/dry period, CAPs reduced the mean corpuscular volume levels and increased erythrocytes, hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution width coefficient variation levels compared with the FA group. Similarly, CAPs during the warm/humid period decreased mean corpuscular volume levels and increased erythrocytes, hemoglobin, hematocrit, and red cell distribution width coefficient variation levels compared with the FA group. CAPs during the cold/dry period increased the influx of neutrophils in the alveolar parenchyma. Short-term exposure to low concentrations of CAPs elicited modest but significant pulmonary inflammation and, to a lesser extent, changes in blood parameters. In addition, our data support the concept that changes in climate conditions slightly modify particle toxicity because equivalent doses of CAPs in the cold/dry period produced a more exacerbated response.
conferenceObject Exercise-induced bronchoconstriction and airway inflammation in elite long distance runners(2014) TEIXEIRA, Renata Nakata; ROMANHOLO, Beatriz Saraiva; AGONDI, Rosana Camara; MARTINS, Milton De Arruda; CARVALHO, Celso R. F.conferenceObject A compare between two models of cigare tie smoke co -exposition in ovalbumin-sensitized mice(2014) BRUGGEMANN, Thayse Regina; FERNANDES, Paula; OLIVEIRA, Jessica Marques Saez; SARAIVA-ROMANHOLO, Beatriz Mangueira; MARTINS, Milton Arruda; ARANTES-COSTA, Fernanda Magalhaes