FABIOLA VILLAC ADDE
Projetos de Pesquisa
Unidades Organizacionais
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
14 resultados
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bookPart Fibrose cística(2022) ADDE, Fabíola VillacconferenceObject QUALITY OF LIFE AND LUNG FUNCTION IN CF PATIENTS USING TOBRAMYCIN INHALATION POWDER (TIP)(2016) CUNHA, Maristela Trevisan; JULIANI, Regina C. T. P.; LEONE, Claudio; RODRIGUES, Joaquim C.; ADDE, Fabiola V.- Acute Bronchodilator Responsiveness to Tiotropium in Postinfectious Bronchiolitis Obliterans in Children(2013) TEIXEIRA, Mariangela F. C.; RODRIGUES, Joaquim C.; LEONE, Claudio; ADDE, Fabiola V.Background: Patients with postinfectious bronchiolitis obliterans (PIBO) usually have severe airflow obstruction and respond poorly to beta-adrenergic drugs. However, the bronchodilator response to an anticholinergic agent such as tiotropium bromide is not known. We studied the acute bronchodilator response to tiotropium for up to 24 h in children with PIBO using spirometric and plethysmographic criteria. Methods: A randomized, double-blind, placebo-controlled, crossover, prospective study was performed in patients with stable PIBO, 6 to 16 years of age. Standard spirometry and plethysmography were performed before and at 30, 60, 120, and 180 min and 24 h after inhalation of 18 mu g of tiotropium or a placebo. After 7 to 14 days, the drugs were inverted, and the procedures were repeated. The changes in lung function parameters at each time point were compared with the baseline by analysis of variance and Tukey posttest, and the differences in all time points assessments vs baseline in tiotropium vs placebo groups were compared using the Friedman test. Results: A total of 30 patients were enrolled in the study (23 boys, seven girls; aged 10.9 +/- 2.8 years) with baseline lung function values (% predicted) of FVC, FEV1, FEV1/FVC, forced expiratory flow between 25% and 75% of FVC (FEF25%-75%), total lung capacity (TLC), residual volume (RV), RV/TLC, airway resistance (Raw), and specific airway conductance (sGaw) of 75 +/- 15, 48 +/- 14, 59 +/- 11, 22 +/- 11, 120 +/- 19, 281 +/- 101, 49 +/- 13, 250 +/- 65, and 23 +/- 9, respectively. Statistically significant differences were observed after tiotropium inhalation in the following parameters compared with baseline: FVC at 60, 120, and 180 min and 24 h; FEV1 at 30, 60, 120, and 180 min; FEV1/FVC at 60, 120, and 180 min; FEF25%-75% at 60, 120, and 180 min; RV at 30, 60, 120, and 180 min; TLC at 30, 120, and 180 min; RV/TLC at 30, 60, 120, and 180 min; Raw at 30, 60, 120, and 180 min and 24 h; and sGaw at 30, 60, 120, and 180 min and 24 h. For the placebo group, no significant differences were observed in any lung function parameters at any time. The differences in the main functional measurements between the tiotropium and placebo groups were statistically significant. Conclusions: Tiotropium acutely decreased airway obstruction and air trapping for up to 24 h in children with PIBO.
bookPart Testes diagnósticos em fibrose cística(2019) ADDE, Fabíola VillacbookPart Introdução(2019) RODRIGUES, Joaquim Carlos; ADDE, Fabíola Villac; SILVA FILHO, Luiz Vicente Ribeiro Ferreira da; NAKAIE, Cleyde Myriam AversabookPart Teste do suor e outros recursos diagnósticos para a fibrose cística(2023) ADDE, Fabíola Villac; SILVA FILHO, Luiz Vicente Ribeiro Ferreira da- Sweat conductivity: An accurate diagnostic test for cystic fibrosis?(2014) MATTAR, Ana Claudia Veras; LEONE, Claudio; RODRIGUES, Joaquim Carlos; ADDE, Fabiola VillacBackground: Sweat chloride test is the gold standard test for cystic fibrosis (CF) diagnosis. Sweat conductivity is widely used although still considered a screening test. Methods: This was a prospective, cross-sectional, diagnostic research conducted at the laboratory of the Instituto da Crianca of the Hospital das Clinicas, Sao Paulo, Brazil. Sweat chloride (quantitative pilocarpine iontophoresis) and sweat conductivity tests were simultaneously performed in patients referred for a sweat test between March 2007 and October 2008. Conductivity and chloride cut-off values used to rule out or diagnose CF were <75 and >= 90 mmol/L and <60 and >= 60 mmol/L, respectively. The ROC curve method was used to calculate the sensitivity, specificity, positive (PPV) and negative predictive value (NPV), as well as the respective 95% confidence intervals and to calculate the area under the curve for both tests. The kappa coefficient was used to evaluate agreement between the tests. Results: Both tests were performed in 738 children, and CF was ruled out in 714 subjects; the median sweat chloride and conductivity values were 11 and 25 mmol/L in these populations, respectively. Twenty-four patients who had received a diagnosis of CF presented median sweat chloride and conductivity values of 87 and 103 mmol/L, respectively. Conductivity values' above 90 mmol/L had 83.3% sensitivity, 99.7% specificity, 90.9% PPV and 99.4% NPV to diagnose CF. The best conductivity cut-off value to exclude CF was <75 mmol/L. Good agreement was observed between the tests (kappa: 0.934). Conclusions: The sweat conductivity test yielded a high degree of diagnostic accuracy and it showed good agreement with sweat chloride. We suggest that it should play a role as a diagnostic test for CF in the near future.
- Six minute walk test Z score: Correlations with cystic fibrosis severity markers(2012) STOLLAR, Fabiola; RODRIGUES, Joaquim C.; CUNHA, Maristela T.; LEONE, Claudio; ADDE, Fabiola VillacBackground: The six-minute-walk-test (6MWT) has been increasingly used in cystic fibrosis (CF) patients. However, few studies in children have correlated 6MWT with current parameters used to evaluate CF severity. Moreover, no study transformed the values of distance walked from meters into Z scores to avoid bias like age and gender, which are sources of 6MWT variability. Methods: A cross-sectional descriptive study was performed to analyze the correlations (Spearman) among forced expiratory volume in one second (FEV1), body mass index (BMI), chest radiography (CXR), chest tomography (CT), and 6MWT Z score (Z-6MWT). Clinically stable CF patients, aged 6-21 years, were included. Results: 34 patients, 14F/20M, mean age 12.1 +/- 4.0 years were studied. The mean Z-6MWT was -1.1 +/- 1.106. The following correlations versus Z-6MWT were found: FEV1 (r=0.59, r(2)=0.32, p=0.0002), BMI Z score (r=0.42, r(2)=0.17, p=0.013), CXR (r=0.34, r(2)=0.15, p=0.0472) and CT (r=-0.45, r(2)=0.23, p=0.0073). Conclusions: In conclusion there was a significant, but poor, correlation between the six minute walk test Z score and the cystic fibrosis severity markers currently in use.
bookPart Medicamentos mais utilizados em pneumologia pediátrica(2019) CARMO, Kátia Maia Martins do; TANAKA, Silvia Onoda Tomikawa; ADDE, Fabíola Villac; RODRIGUES, Joaquim CarlosconferenceObject EARLY PSEUDOMONAS AERUGINOSA COLONIZATION IN CYSTIC FIBROSIS: LONG TERM RESULTS OF AN ERADICATION PROTOCOL(2016) ADDE, Fabiola Villac; RIQUENA, Barbara; SILVA FILHO, Luiz Vicente R. F.; NAKAIE, Cleyde M. A.; ALMEIDA, Marina B.; RODRIGUES, Joaquim C.