ELISA MARIA SIQUEIRA LOMBARDI
Projetos de Pesquisa
Unidades Organizacionais
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
19 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 19
bookPart Pneumoconiose por Poeira Mista e Silicatoses(2014) LOMBARDI, Elisa Maria Siqueira; CHATE, Rodrigo Caruso; SANTOS, Ubiratan de Paula; TERRA FILHO, MáriobookPart Tabagismo: Impactos na Saúde, Prevenção e Tratamento(2016) SANTOS, Ubiratan de Paula; PRADO, Gustavo Faibischew; MARTINS, Stella Regina; LOMBARDI, Elisa Maria Siqueira- Biomarkers related to silicosis and pulmonary function in individuals exposed to silica(2023) LOMBARDI, Elisa M. S.; MIZUTANI, Rafael F.; TERRA-FILHO, Mario; PAULA, Santos Ubiratan deBackgroundThe identification of markers that can facilitate the early diagnosis of silicosis has remained challenging. We evaluated the association of inflammatory markers with the presence of silicosis and lung function impairment in individuals exposed to silica. Methods Individuals exposed and not exposed to silica were assessed by occupational history, clinical findings, lung function, chest imaging findings, and inflammatory markers. Results Among 297 men evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), and macrophage inflammatory protein-4 (MIP-4) were associated with silicosis, and LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and fibrinogen were negatively associated with lung function. Conclusion Blood inflammatory markers are associated with silicosis and impaired lung function.
bookPart Doenças Respiratórias Ocupacionais(2016) SANTOS, Ubiratan de Paula; LOMBARDI, Elisa Maria Siqueira; PRADO, Gustavo FaibischewconferenceObject Silicosis in a Rutile Mining, Bahia/Brazil(2018) VASCONCELOS, I. M.; SERRA, J. P.; JESUS, R. M.; LOMBARDI, E. M.; SANTOS, U. P.- A real-life study of the effectiveness of different pharmacological approaches to the treatment of smoking cessation: re-discussing the predictors of success(2011) PRADO, Gustavo Faibischew; LOMBARDI, Elisa Maria Siqueira; BUSSACOS, Marco Antonio; ARRABAL-FERNANDES, Frederico Leon; TERRA-FILHO, Mario; SANTOS, Ubiratan de PaulaOBJECTIVE: To evaluate the effectiveness of nicotine replacement therapy (NRT), bupropion, nortriptyline and combination therapy and describe factors associated with treatment success. INTRODUCTION: Clinical trials clearly demonstrate the efficacy of pharmacotherapy in smoking cessation. However, it is only after its use in real-life settings that clinical effectiveness and limitations of a treatment are fully known. METHODS: Patients attended a four-session cognitive-behavioral program and received medicines free of charge. Abstinence from smoking was assessed at each visit. RESULTS: A total of 868 smokers (68.8% women) were included. Their mean age was 49.6 years; the amount smoked was 25 cigarettes/day and the Fagerstrom Score was 6.6. Abstinence rates after 6 months and 1 year were 36.5% and 33.6%. In univariate analysis, male gender, age (> 50), higher number of cigarettes smoked, cardiovascular comorbidities, longer interval from the last cigarette and combined treatment of nortriptyline plus NRT were predictive of abstinence, while neuropsychiatric comorbidities and the answer ""yes'' to the question ""Do you smoke more often during the first hours after waking'' were correlated with failure. In a multivariate model, predictors of abstinence were neuropsychiatric comorbidities, the answer ""yes'' to the question ""Do you smoke more often during the first hours after waking'' and combined treatment of nortriptyline plus NRT. Male gender and a longer period from the last cigarette were correlated with lower abstinence rate. CONCLUSION: Satisfactory success rates were obtained in a teaching hospital. Factors such as age, daily cigarette consumption, number of pack-years and dependency score were not reliable markers of abstinence. The combination nortriptyline+NRT was independently associated with higher abstinence rates.
conferenceObject Smoking status, prevalence of smoking-related diseases and their impact on costs in patients hospitalized in the thoracic units of a tertiary hospital in Brazil(2013) MORAIS, Anna Miethke; LOMBARDI, Elisa Maria Siqueira; PRADO, Gustavo F.; MARTINS, Stella R.; PACELI, Renato; TERRA-FILHO, Mario; SANTOS, Ubiratan de Paula- Clinical, functional and biomarkers differences between subjects exposed to silica, with and without silicosis(2018) LOMBARDI, Elisa; PRADO, Gustavo Faibischew; TERRA FILHO, Mario; SANTOS, Ubiratan Paula
conferenceObject 6-minute walking test (6MWT) in patients with silicosis(2013) COZZA, Izabela; LOMBARDI, Elisa; PRADO, Gustavo; TERRA, Mario; SANTOS, Ubiratan- Knowledge of and attitudes toward the WHO MPOWER policies to reduce tobacco use at the population level: a comparison between third-year and sixth-year medical students(2021) MARTINS, Stella Regina; SZKLO, Andre Salem; BUSSACOS, Marco Antonio; PRADO, Gustavo Faibischew; PACELI, Renato Batista; FERNANDES, Frederico Leon Arrabal; LOMBARDI, Elisa Maria Siqueira; BASSO, Rafaela Giunti; TERRA-FILHO, Mario; SANTOS, Ubiratan PaulaObjective: To evaluate third- and sixth-year medical students in Brazil in terms of their knowledge of and attitudes toward the WHO MPOWER policies to reduce tobacco use. Methods: The WHO Global Health Professions Student Survey was applied in five cohorts of medical students evaluated in their third and sixth years of medical school, between 2008 and 2015. Comparisons were drawn between the two years of medical school in terms of the proportions of students who experimented with or used tobacco products in the last 30 days prior to the survey; knowledge of and compliance with smoke-free policies on the university campus; formal training on smoking cessation strategies; and self-recognition as role models for patients/society. Results: Of the 943 students who completed the survey, approximately 6% had smoked cigarettes in the last 30 days prior to the survey. Comparing the third and sixth years of medical school, we observed a significant increase in the proportion of students who were knowledgeable about smoking cessation strategies (22.74% vs. 95.84%; p < 0.001) and in that of those who recognized their role as models for patients/society (84.5% vs. 89.7%; p = 0.023). Student knowledge of the smoking policies on the university campus was associated with an increase in self-recognition as role models (adjusted absolute difference = 6.7%; adjusted p = 0.050). Conclusions: Knowledge of smoking cessation strategies and self-recognition as role models for patients/society increase over the course of medical school and are associated with the implementation of smoke-free policies.