ROBERTA DIEHL RODRIGUEZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
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conferenceObject Inflammatory factors (cytokines and cortisol) across different brain regions in bipolar disorder and their associations with neuropsychiatric symptoms: A post-mortem study(2020) NASCIMENTO, Camila; NUNES, Paula V.; SUEMOTO, Claudia K.; RODRIGUEZ, Roberta D.; LEITE, Renata E. P.; GRINBERG, Lea T.; PASQUALUCCI, Carlos A.; NITRINI, Ricardo; JACOB-FILHO, Wilson; BRENTANI, Helena P.; LAFER, Beny- Evaluation of the diaphragm muscle remodeling, inflammation, oxidative stress and vascularization in smokers: An autopsy study(2020) NUCCI, R.A.B.; MAIFRINO, L.B.M.; BUSSE, A.L.; SOUZA, R.R. De; PASQUALUCCI, C.A.; ANARUMA, C.A.; LEITE, R.E.P.; RODRIGUEZ, R.D.; SUEMOTO, C.K.; JACOB-FILHO, W.Background/Aims: Cigarette smoking is a key factor in systemic inflammation and oxidative stress, and it has also been associated with the loss of muscle strength and an elevated risk of pulmonary diseases. Thus, this study aimed to analyze the effects of cigarette smoking on the diaphragm muscle structure of postmortem samples. Methods: Immunohistochemical techniques were used for muscle remodeling (metalloproteinases 2 and 9), inflammation (cyclooxygenase-2), oxidative stress (8-hydroxy-2'-deoxyguanosine), and vascularization (vascular endothelial growth factor). Hematoxylin and eosin stain was used for histopathological analysis and Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of diaphragm muscle remodeling, oxidative stress, inflammation, and vascularization compared to non-smokers. Conclusion: Diaphragm muscle structure may be negatively affected by cigarette smoking. © 2020 The Author(s).
- Determinants of microcephaly in adults using data mining: increased risk for dementia and greater association with male gender(2020) MANCINE, L.; SUEMOTO, C. K.; RODRIGUEZ, R. D.; LEITE, R. E. P.; NASCIMENTO, C.; FERRETI-REBUSTINI, R.; TEIXEIRA, J. D. M.; PASQUALUCCI, C. A.; NITRINI, R.; JACOB-FILHO, W.; GRINBERG, L.; SALVINI, R.; NUNES, P. V.
- Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of A beta Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model(2020) SELLES, Maria Clara; FORTUNA, Juliana T. S.; ZAPPA-VILLAR, Maria F.; FARIA, Yasmin P. R. de; SOUZA, Amanda S.; SUEMOTO, Claudia K.; LEITE, Renata E. P.; RODRIGUEZ, Roberta D.; GRINBERG, Lea T.; REGGIANI, Paula C.; FERREIRA, Sergio T.Alzheimer's disease (AD) is the main cause of dementia in the elderly. Although activation of brain insulin signaling has been shown to be neuroprotective, to preserve memory in AD models, and appears beneficial in patients, the role of insulin-like growth factor 1 (IGF1) remains incompletely understood. We found reduced active/inactive IGF1 ratio and increased IGF1R expression in postmortem hippocampal tissue from AD patients, suggesting impaired brain IGF1 signaling in AD. Active/inactive IGF-1 ratio was also reduced in the brains of mouse models of AD. We next investigated the possible protective role of IGF1 in AD models. We used a recombinant adenoviral vector, RAd-IGF1, to drive the expression of IGF1 in primary hippocampal neuronal cultures prior to exposure to A beta Os, toxins that accumulate in AD brains and have been implicated in early synapse dysfunction and memory impairment. Cultures transduced with RAd-IGF1 showed decreased binding of A beta Os to neurons and were protected against A beta O-induced neuronal oxidative stress and loss of dendritic spines. Significantly, in vivo transduction with RAd-IGF1 blocked memory impairment caused by intracerebroventricular (i.c.v.) infusion of A beta Os in mice. Our results demonstrate altered active IGF1 and IGF1R levels in AD hippocampi, and suggest that boosting brain expression of IGF1 may comprise an approach to prevent neuronal damage and memory loss in AD.
- Rasmussen encephalitis: an older adult presentation?(2020) ALVIM, Ricardo Pires; AGUIAR, Patrick; AMADO, Daniel Kempel; ROCHA, Maria Sheila Guimarães; RODRIGUEZ, Roberta Diehl; BRUCKI, Sonia Maria DozziABSTRACT. Rasmussen encephalitis (RE) is a classic disorder in the child age group, and only 10% of cases are described in adults. We bring two proven cases of RE in older adults aged over 55 years. Objective: To describe the clinical characteristics, progression, diagnostic assessment, neuropathological findings, and treatment of RE in two clinical cases of patients over 55 years of age. Furthermore, we address progressive cognitive decline as an important feature of the RE presentation in older adults in association with focal epilepsy. Methods: This is a case series from two tertiary hospitals from São Paulo – Brazil. Retrospective data were collected from one case. Results: Two male individuals aged >55 years with clinical presentation of focal epilepsy along with progressive cognitive deterioration. Conclusions: RE could be considered the cause of progressive cognitive decline in older adults, especially if focal epilepsy is described together with asymmetrical neuroimaging findings.
bookPart Diagnóstico e tratamento das demências vasculares e potencialmente reversíveis(2020) RICARDO, Laiss Bertola de Moura; RODRIGUEZ, Roberta Diehl; SUEMOTO, Claudia Kimie- Differential levels of inflammatory and neuroendocrine markers in the hippocampus and anterior cingulate cortex of bipolar disorder subjects: A post-mortem study(2020) NASCIMENTO, Camila; NUNES, Paula Villela; SUEMOTO, Claudia Kimie; RODRIGUEZ, Roberta Diehl; LEITE, Renata Elaine Paraizo; GRINBERG, Lea Tenenholz; PASQUALUCCI, Carlos Augusto; NITRINI, Ricardo; JACOB-FILHO, Wilson; BRENTANI, Helena Paula; LAFER, Beny
- Response letter: neuropathological lesions in the very old(2020) SUEMOTO, Claudia K.; LEITE, Renata E. P.; FERRETTI-REBUSTINI, Renata E. L.; RODRIGUEZ, Roberta D.; NITRINI, Ricardo; PASQUALUCCI, Carlos A.; JACOB-FILHO, Wilson; GRINBERG, Lea T.
conferenceObject Increased Levels of Inflammatory Cytokines across Different Brain Regions in Bipolar Disorder and its Correlation With Cortisol and Neuropsychiatric Symptoms: A Post-Mortem Study(2020) NUNES, Paula; NASCIMENTO, Camila; SUEMOTO, Claudia; RODRIGUEZ, Roberta; LEITE, Renata; GRINBERG, Lea; PASQUALUCCI, Carlos; NITRINI, Ricardo; JACOB-FILHO, Wilson; LAFER, Beny