CESAR DE ALMEIDA NETO
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- Tools to implement and improve blood donor hemovigilance in Brazil(2014) ALMEIDA NETO, Cesar de
- Risk factors for deferral due to low hematocrit and iron depletion among prospective blood donors in a Brazilian center(2015) DAUAR, Eloísa Tedeschi; PATAVINO, Giuseppina Maria; MENDRONE JÚNIOR, Alfredo; GUALANDRO, Sandra Fátima Menosi; SABINO, Ester Cerdeira; ALMEIDA-NETO, Cesar deOBJECTIVE: Deferral of blood donors due to low hematocrit and iron depletion is commonly reported in blood banks worldwide. This study evaluated the risk factors for low hematocrit and iron depletion among prospective blood donors in a large Brazilian blood center.METHOD: A case-control study of 400 deferred donors due to low hematocrit and 456 eligible whole blood donors was conducted between 2009 and 2011. Participants were interviewed about selected risk factors for anemia, and additional laboratory tests, including serum ferritin, were performed. Bivariate and multivariate analyses were performed to assess the association between predictors and deferral due to low hematocrit in the studied population and iron depletion in women.RESULTS: Donors taking aspirins or iron supplementation, those who reported stomachache, black tarry stools or hematochezia, and women having more than one menstrual period/month were more likely to be deferred. Risk factors for iron depletion were repeat donation and being deferred at the hematocrit screening. Smoking and lack of menstruation were protective against iron depletion.CONCLUSION: This study found some unusual risk factors related to gastrointestinal losses that were associated with deferral of donors due to low hematocrit. Knowledge of the risk factors can help blood banks design algorithms to improve donor notification and referral.
- Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil(2014) LOUREIRO, Paula; ALMEIDA-NETO, Cesar de; PROIETTI, Anna Bárbara Carneiro; CAPUANI, Ligia; GONÇALEZ, Thelma Terezinha; OLIVEIRA, Claudia Di Lorenzo de; LEÃO, Silvana Carneiro; LOPES, Maria Inês; SAMPAIO, Divaldo; PATAVINO, Giuseppina Maria; FERREIRA, João Eduardo; BLATYTA, Paula Fraiman; LOPES, Maria Esther Duarte; MENDRONE-JUNIOR, Alfredo; SALLES, Nanci Alves; KING, Melissa; MURPHY, Edward; BUSCH, Michael; CUSTER, Brian; SABINO, Ester CerdeiraThe Retrovirus Epidemiology Donor Study (REDS) program was established in the United States in 1989 with the purpose of increasing blood transfusion safety in the context of the HIV/AIDS and human T-lymphotropic virus epidemics. REDS and its successor, REDS-II were at first conducted in the US, then expanded in 2006 to include international partnerships with Brazil and China. In 2011, a third wave of REDS renamed the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) was launched. This seven-year research program focuses on both blood banking and transfusion medicine research in the United States of America, Brazil, China, and South Africa. The main goal of the international programs is to reduce and prevent the transmission of HIV/AIDS and other known and emerging infectious agents through transfusion, and to address research questions aimed at understanding global issues related to the availability of safe blood. This article describes the contribution of REDS-II to transfusion safety in Brazil. Articles published from 2010 to 2013 are summarized, including database analyses to characterize blood donors, deferral rates, and prevalence, incidence and residual risk of the main blood-borne infections. Specific studies were developed to understand donor motivation, the impact of the deferral questions, risk factors and molecular surveillance among HIV-positive donors, and the natural history of Chagas disease. The purpose of this review is to disseminate the acquired knowledge and briefly summarize the findings of the REDS-II studies conducted in Brazil as well as to introduce the scope of the REDS-III program that is now in progress and will continue through 2018.
- Temporal distribution of blood donations in three Brazilian blood centers and its repercussion on the blood supply(2013) OLIVEIRA, Claudia Di Lorenzo; ALMEIDA-NETO, Cesar de; LIU, Emily Jing; SABINO, Ester Cerdeira; LEAO, Silvana Carneiro; LOUREIRO, Paula; WRIGHT, David; CUSTER, Brian; GONCALEZ, Thelma Therezinha; CAPUANI, Ligia; BUSCH, Michael; PROIETTI, Anna Barbara de Freitas CarneiroBACKGROUND: Seasonal distribution of blood donation hinders efforts to provide a safe and adequate blood supply leading to chronic and persistent shortages. This study examined whether holidays, geographical area and donation type (community versus replacement) has any impact on the fluctuation of donations. METHODS: The numbers of blood donations from 2007 through 2010 in three Brazilian Retrovirus Epidemiological Donor Study II (REDS-II) participating centers were analyzed according to the week of donation. The weeks were classified as holiday or non-holiday. To compare donations performed during holiday versus non-holiday weeks, tabulations and descriptive statistics for weekly donations by blood center were examined and time series analysis was conducted. RESULTS: The average weekly number of donations varied according to the blood center and type of week. The average number of donations decreased significantly during Carnival and Christmas and increased during the Brazilian National Donor Week. The fluctuation was more pronounced in Recife and Belo Horizonte when compared to São Paulo and higher among community donors. CONCLUSION: National bank holidays affect the blood supply by reducing available blood donations. Blood banks should take into account these oscillations in order to plan local campaigns, aiming at maintaining the blood supply at acceptable levels.
- Health-related quality of life among blood donors with hepatitis B and hepatitis C: longitudinal study before and after diagnosis(2015) FERREIRA, Francisco Augusto Porto; ALMEIDA-NETO, Cesar de; TEIXEIRA, Maria Cristina Dias; STRAUSS, EdnaABSTRACT Introduction: There is evidence that patients suffering from chronic hepatic diseases, including chronic hepatitis B and chronic hepatitis C, have a reduced health-related quality of life. The aim of this study was to evaluate the impact of the notification of test results for hepatitis B and hepatitis C on the quality of life of blood donors. Methods: Over a 29-month period, this study assessed the quality of life of 105 blood donors with positive serological screening tests for hepatitis B and hepatitis C and donors who presented false-positive test results. The Medical Outcome Study 36-Item Short Form Health Survey Questionnaire was applied at three time points: (1) when an additional blood sample was collected for confirmatory tests; (2) when donors were notified about their serological status; and (3) when donors, positive for hepatitis B and hepatitis C, started clinical follow- up. Quality of life scores for the confirmed hepatitis B and hepatitis C groups were compared to the false-positive control group. Results: The domains bodily pain, general health perception, social function, and mental health and the physical component improved significantly in donors with hepatitis C from Time Point 1 to Time Point 3. Health-related quality of life scores of donors diagnosed with hepatitis B and hepatitis C were significantly lower in six and four of the eight domains, respectively, compared to the false-positive control group. Conclusion: A decreased quality of life was detected before and after diagnosis in blood donors with hepatitis B and hepatitis C. Contrary to hepatitis B positive donors, the pos- sibility of medical care may have improved the quality of life among hepatitis C positive donors.