JOSE ANTONIO MIGUEL MARCONDES
Projetos de Pesquisa
Unidades Organizacionais
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Metformin versus lifestyle changes in treating women with polycystic ovary syndrome(2012) CURI, Daniella D. G.; FONSECA, Angela Maggio; MARCONDES, Jose Antonio M.; ALMEIDA, Jose Alcione M.; BAGNOLI, Vicente R.; SOARES- JR., Jose Maria; BARACAT, Edmund ChadaObjective: To compare the efficacy of metformin with that of lifestyle changes in patients with polycystic ovary syndrome (PCOS). Design: Prospective, randomized clinical trial of 40 women with PCOS to analyze the effects of metformin and lifestyle intervention treatments on menstrual pattern and hormone and metabolic profile. The duration of treatment was 6 months. Statistical analysis was done using Student's t-test. Results: Fifteen women in the metformin group and 12 in the lifestyle changes group completed the study. The menstrual pattern improved by similar to 67% in both groups. There was a significant decrease in waist circumference in the lifestyle changes group (101.8 +/- 3.9 and 95.1 +/- 3.6, at baseline and at 6 months of treatment, respectively; p<0.001) and in body mass index (BMI) in both groups. The predictor of menstrual pattern improvement was BMI. Conclusions: Both metformin and lifestyle changes may increase the number of menstrual cycles in PCOS. This effect was related to a decrease in BMI.
bookPart Hiperandrogenismo(2013) HAYASHIDA, Sylvia Asaka Yamashita; MACIEL, Gustavo Arantes Rosa; MARCONDES, Jose Antonio Miguel; JúNIOR, José Maria Soares; BARACAT, Edmund ChadaconferenceObject The Influence of Insulin on the Degree of Hirsutism of Patients with Polycystic Ovary Syndrome(2014) HAYASHIDA, Sylvia Yamashita; SOARES JR., Jose Maria; MIRALDI, Priscila Dias; MARCONDES, Jose Antonio; BARCELLOS, Cristiano Roberto; ANZAI, Alvaro; MACIEL, Gustavo Arantes R.; BARACAT, Edmund Chada- Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome(2011) MACIEL, Gustavo Arantes Rosa; HAYASHIDA, Sylvia Asaka Yamashita; COSTA, Lia Cruz Vaz da; MARCONDES, Jose Antonio Miguel; FONSECA, Angela Maggio da; SOARES JR., Jose Maria; BARACAT, Edmund ChadaObjective: To search for predictors of metformin response in women with polycystic ovary syndrome (PCOS) through a detailed analysis of clinical and laboratory parameters. Study design: We designed a prospective study to investigate clinical and laboratory parameters to search for predictors of metformin response in women with PCOS. A total of 53 PCOS patients were given metformin 850 mg twice a day for 6 months, after which patients were classified as responders or non-responders. Parameters analyzed for comparison between the two groups were: plasma fasting insulin glucose/insulin ratio; oral glucose tolerance test (OGTT) with insulin (120 min); HOMA and QUICKI tests; total cholesterol and fractions, triglycerides; LH, FSH, estradiol, progesterone, testosterone, androstenedione, 17-OH progesterone, and DHEAS. Results: From all patients, 30(56.6%) were responders and 23(43.3%) were non-responders. Multinomial analysis showed that the positive response to metformin was associated with higher levels of basal LH (p = 0.038) and lower levels of high-density lipoprotein cholesterol (HDL-C) (p = 0.015). Conclusion: In weight-matched PCOS subjects, laboratory markers might predict the metformin response. Higher levels of basal LH and lower levels of HDL-C are correlated with a positive response to metformin treatment in PCOS subjects.