JOSE ANTONIO MIGUEL MARCONDES

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Assunto: hyperandrogenism ×

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  • article 26 Citação(ões) na Scopus
    Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies
    (2017) YANCE, V. R. V.; MARCONDES, J. A. M.; ROCHA, M. P.; BARCELLOS, C. R. G.; DANTAS, W. S.; AVILA, A. F. A.; BARONI, R. H.; CARVALHO, F. M.; HAYASHIDA, S. A. Y.; MENDONCA, B. B.; DOMENICE, S.
    Background: The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is often difficult. Objective: To evaluate the contribution of clinical features, hormonal profiles and radiological studies to the differential diagnosis of VOT and OH. Design: A retrospective study. Setting: A tertiary center. Main outcome measures: Clinical data, hormonal status (T, E2, LH and FSH), pelvic images (transvaginal sonography and MRI) and anatomopathology were reviewed. Patients: Thirty-four postmenopausal women with a diagnosis of VOT (13 women) and OH (21 women) were evaluated retrospectively. Results: Clinical signs of hyperandrogenism were more prevalent in the VOT group than the OH group. Although the VOT group showed higher T and E2 levels and lower gonadotropin levels than the OH group, a great overlap occurred among the hormone levels. A pelvic MRI provided an accurate differentiation of these two conditions. Conclusion: In this group of patients, the main features contributing to the differential diagnosis of VOT and OH were serum levels of testosterone and gonadotropins and the presence of an ovarian nodule identified on the MRI. Although the association of clinical, hormonal and radiological features contributes to the differential diagnosis of these two conditions, histopathological analysis remains the gold standard for the diagnosis of ovarian hyperandrogenism in postmenopausal women.
  • article 4 Citação(ões) na Scopus
    Changing pattern of gonadotropins in a patient with an adrenal-androgen secreting tumor
    (2011) MARCONDES, Jose Antonio Miguel; BARCELLOS, Cristiano R. G.; ROCHA, Michelle P.; BISI, Helio
  • article 17 Citação(ões) na Scopus
    Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors
    (2015) BARCELLOS, Cristiano Roberto Grimaldi; ROCHA, Michelle Patrocinio; HAYASHIDA, Sylvia Asaka Yamashita; DANTAS, Wagner Silva; YANCE, Viviane dos Reis Vieira; MARCONDES, Jose Antonio Miguel
    OBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension). DESIGN: Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-alpha, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-alpha were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). CONCLUSION: Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without majorCV risk factors.
  • article 14 Citação(ões) na Scopus
    A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor
    (2011) FARIA, Andre M.; PEREZ, Ricardo V.; MARCONDES, Jose A. M.; FREIRE, Daniel S.; BLASBALG, Roberto; SOARES JR., Jose; SIMOES, Kleber; HAYASHIDA, Sylvia A. Y.; PEREIRA, Maria A. A.
    Background. A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization. Investigations. Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging. Diagnosis. Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.