LAWRENCE HSU LIN
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
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- Androgen receptor gene polymorphism and polycystic ovary syndrome(2013) LIN, Lawrence H.; BARACAT, Maria C. P.; MACIEL, Gustavo A. R.; SOARES JR., Jose M.; BARACAT, Edmund C.Background: Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism. Its etiopathology is not well understood but genetic factors seem to have a role. Polymorphism of the androgen receptor (AR) gene has been associated with different androgen pattern diseases. Objective: To review the association between AR gene polymorphism and PCOS. Search strategy: A systematic review was performed via PUBMED, EMBASE, and LILACS (up to May 31, 2011). Selection criteria: Studies assessing the presence of the (CAG)(n) polymorphism of the AR gene in at least 2 comparison groups (PCOS and control). Studies that did not contain adequate information were excluded. Data collection and analysis: Study characteristics and results were analyzed. Meta-analysis could not be performed because only 2 articles provided odds ratios. Main results: Ten studies met the inclusion criteria. Three studies reported a correlation between the polymorphism and PCOS; 2 studies linked the disorder to shorter repeats, whereas the other associated it with longer repeats. Conclusion: Polymorphism of the AR gene seems to be a promising biomarker for PCOS because shorter repeats may be linked to the disorder. However, further studies are needed to understand the association fully.