MILENA PEREZ MAK

(Fonte: Lattes)
Índice h a partir de 2011
11
Lattes
ResearcherID
ORCID
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

Autor: CASTRO JUNIOR, Gilberto de ×

Resultados de Busca

Agora exibindo 1 - 8 de 8
  • bookPart
    Câncer de pulmão
    (2023) FêDE, Angelo Bezerra de Souza; TAKAHASHI, Tiago Kenji; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • bookPart
    Câncer de cabeça e pescoço
    (2017) LIMA, Rafael Caires Alvino de; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • bookPart
    Câncer de pulmão
    (2017) FêDE, Angelo Bezerra de Souza; TAKAHASHI, Tiago Kenji; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • bookPart
    Câncer de cabeça e pescoço
    (2015) LIMA, Rafael Caires Alvino de; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • article 24 Citação(ões) na Scopus
    Postradiation Matrix Metalloproteinase-20 Expression and Its Impact on Dental Micromorphology and Radiation-Related Caries
    (2017) GOMES-SILVA, Wagner; PRADO-RIBEIRO, Ana Carolina; BRANDAO, Thais Bianca; MORAIS-FARIA, Karina; CASTRO JUNIOR, Gilberto de; MAK, Milena Perez; LOPES, Marcio Ajudarte; ROCHA, Marcelo Marques; SALO, Tuula; TJADERHANE, Leo; GOES, Mario Fernando de; SANTOS-SILVA, Alan Roger
    Recent evidence suggests that head-and-neck radiotherapy (HNRT) increases active forms of matrix metalloproteinase-20 (MMP-20) in human tooth crowns, degrading the dentin-enamel junction (DEJ) and leading to enamel delamination, which is a pivotal step in the formation of radiation-related caries (RRC). Additional participation of enzymatic degradation of organic matrix components in caries progression was attributed to MMP-20 in dentin. Therefore, the current study tested the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes to the enamel and dentin. Thirty-six teeth were studied, including 19 post-HNRT specimens and 17 nonirradiated controls. Optical light microscopy was used to investigate the micromorphological components of the DEJ, dentin-pulp complex components, and carious dentin. The samples were divided into 2 subgroups: nondemineralized ground sections (n = 20) and demineralized histological sections (n = 16). In addition, immunohistochemical analysis using the immunoperoxidase technique was conducted to semiquantitatively assess MMP-20 expression in the DEJ, dentin-pulp complex components, and carious dentin. No apparent damage to the DEJ microstructure or other dentin-pulp complex components was observed and no statistically significant differences were detected in MMP-20 expression (p > 0.05) between the irradiated and control groups. This study rejected the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes. Hence, direct effects of radiation may not be regarded as an independent factor to explain aggressive clinical patterns of RRC. (C) 2017 S. Karger AG, Basel
  • bookPart
    Câncer de pulmão
    (2015) FêDE, Angelo Bezerra de Souza; TAKAHASHI, Tiago Kenji; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • bookPart
    Câncer de cabeça e pescoço
    (2023) LIMA, Rafael Caires Alvino de; MAK, Milena Perez; CASTRO JUNIOR, Gilberto de
  • article 33 Citação(ões) na Scopus
    Advanced prostate cancer as a cause of oncogenic osteomalacia: an underdiagnosed condition
    (2012) MAK, Milena Perez; SILVA, Veronica Torres da Costa e; MARTIN, Regina Matsunaga; LERARIO, Antonio Marcondes; YU, Luis; HOFF, Paulo Marcelo Gehm; CASTRO JUNIOR, Gilberto de
    Tumor-induced osteomalacia (TIO) is a paraneoplastic bone mineral disturbance related to fibroblast growth factor 23 (FGF23) overproduction by the tumor, usually from mesenchymal origin. Such condition leads to high phosphate renal wasting and, consequently, to cumbersome symptoms as weakness, bone pain, and fractures. Case report. We report a case of an advanced castration-refractory prostate cancer patient, which developed severe hypophosphatemia with elevated phosphate excretion fraction. TIO was suspected, and increased levels of FGF23 reinforced such diagnosis. The patient died 4 months after being diagnosed with TIO. This case suggests that TIO has a dismal prognosis in prostate cancer patients. The clinical oncology community must be aware about such disturbance that can be present in those patients with weakness, bone pain, and hypophosphatemia.