HANIEL ALVES ARAUJO
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- Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes(2018) SOUZA, B. B. de; ARAúJO, H. A.; GIRALDEZ, V. Z. R.; LIBBY, P.; GIRALDEZ, R. R. C. V.The endothelium plays a central role in vascular homeostasis. Indeed, when dysfunctional, the endothelium governs the genesis of atherosclerotic disease, mediating the relationship between cardiovascular risk factors (such as smoking, hypertension, dyslipidemia, and diabetes) and the initiation and evolution of atherosclerotic plaque. Despite the relevance of the endothelium in the insidious atherosclerotic process, it has received limited attention in the context of acute atheroma complications, as ruptures of the fibrous cap of lipid-rich plaques have dominated discussions of the major causes of acute coronary syndromes (ACS). Yet, recent studies have shown that superficial erosion may be rising as a cause of ACS while the prevalence of plaque rupture is waning. The term “erosion” suggests that a dysfunctional or absent layer of endothelium promotes thrombosis, but probing the mechanisms of such erosive events has been scarce. This chapter considers the potential pathophysiologic pathways that promote superficial erosion and discusses the involvement of the endothelium in nonatherosclerotic causes of ACS and in the vascular events following ACS. © 2018 Elsevier Inc. All rights reserved.
bookPart Toxicidades do tratamento e seu manejo(2023) SOARES, Gabriella Fernandes; ARAUJO, Haniel Alves; MAK, Milena PerezbookPart Mecanismos moleculares das alteraçãoes da parede arterial nas síndromes coronarianas agudas(2016) SOUZA, Breno Bernardes de; GIRALDEZ, Viviane Zorzanelli Rocha; GIRALDEZ, Roberto Rocha C. V.; ARAúJO, Haniel Alves; LIBBY, Peter