MARCELLO MENTA SIMONSEN NICO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Adhesion molecules in primary oral mucosal melanoma: Study of integrins, claudins and immunoglobulins in a series of 35 cases(2012) LOURENCO, S.; BOLOGNA, S.; COUTINHO-CAMILLO, C.; FERNANDES, J.; SANGUEZA, M.; SOARES, F.; MENTA, M.Objective: Primary oral mucosal melanoma is a rare and aggressive tumor. Recent studies have reported a correlation between increased tumor invasion and metastatic phenotype with an altered expression of adhesion molecules profiles. The present study analyzed the expression of integrins, claudins and immunoglobulins in oral mucosal melanomas and correlated results with clinical features of patients. Method: Immunohistochemistry against these molecules was performed in thirty-five cases of primary oral mucosal melanomas organized into “tissue microarray ”and the results were related to clinical and histological features of patients. Results: Some subunits of integrins presented down-regulation and this was associated with vascular invasion. Increased expression of integrin beta3 and immunoglobulin CD166 (ALCAM) was statistically associated with cases with extensive vascular invasion (p <0,05). Lower expression of the immunoglobulin CD54 (ICAM) was associated with cases with extensive necrosis. Most cases with metastasis were negative for immunoglobulin CD66 (CEACAM). Several subunits of claudins showed down-regulation in the cases analyzed, and, although not statistically significant, it showed to be partially related with histological factors of poor prognosis. Conclusion: Altered patterns of adhesion molecules, mainly integrins and immunoglobulin seem to participate in the pathogenesis and outcome of oral mucosal melanomas.conferenceObject IgG4-related disease: Salivary glands peculiarities and differences with Sjogren's Syndrome(2014) BOLOGNA, S.; NUNES, T.; COUTINHO-CAMILLO, C.; PASOTO, S.; MACHADO, B.; NICO, M.; LOURENCO, S.- The lip in lupus erythematosus(2014) NICO, M. M. S.; BOLOGNA, S. B.; LOURENCO, S. V.Lupus erythematosus (LE) frequently compromises the skin, lips and oral mucosa. There is a large body of medical and dental literature about the cutaneous and mucosal lesions of LE, but very little has been written specifically about labial lupus. The lip has a peculiar anatomical and histological architecture, and LE lesions at this site may have some distinct features. This article reviews the existing data and adds some new concepts to the issue of labial lupus in all of its presentations, comparing such lesions to the well-established characterization of cutaneous LE (in acute, subacute and chronic lesions), and highlighting some special clinical features that may enable a better diagnosis and differential diagnosis of lip diseases.
conferenceObject Morphological alterations in labial salivary gland in patients who underwent radiotherapy(2013) BOLOGNA, S.; TESHIMA, T. H. N.; NUNES, T. B.; DURAZZO, M. D.; NICO, M. M. Simonsen; LOURENCO, S. V.bookPart Manifestações orais na doença inflamatória intestinal(2015) NICO, Marcelo Menta Simonsen; BOLOGNA, Sheyla Batista; LOURENçO, Silvia Vanessa- An Atrophic, Telangiectatic Patch at the Distal Border of the Tongue: A Mucous Membrane Manifestation of Xeroderma Pigmentosum(2014) BOLOGNA, Sheyla Batista; TESHIMA, Tathyane Harumi Nakajima; LOURENCO, Silvia Vanessa; NICO, Marcello Menta SimonsenXeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by clinical and cellular sensitivity, pigmentary changes, and early development of malignancies in sun-exposed mucocutaneous and ocular structures due to a defective ability to repair intracellular DNA damage. Individuals with XP also have a greater frequency of oral cancer, particularly squamous cell carcinoma of the anterior third of the tongue. The current study reports four cases of XP that exhibited a characteristic crescent-shaped, atrophic, telangiectatic area on the distal border of the tongue and correlates this lesion with the development of tumors at this site during follow-up. The tongue lesion was photographed and biopsied in the four patients. During routine follow-up visits, new biopsies were performed if additional tongue lesions were observed. The studied lesions were similar in the four patients. During follow-up, squamous cell carcinoma developed in one patient and pyogenic granuloma developed in three patients and was relapsing in one. The lesion remained stable in one patient during the study. The atrophic and telangiectatic patches probably occur because of chronic sun damage to the exposed portion of the tongue, and this area has a high predisposition for the development of benign and malignant tumors.
- Head and Neck Mucosal Melanoma: A Review(2014) LOURENCO, Silvia V.; FERNANDES, Juliana D.; HSIEH, Ricardo; COUTINHO-CAMILLO, Claudia M.; BOLOGNA, Sheyla; SANGUEZA, Martin; NICO, Marcello M. S.Head and neck mucosal melanoma (MM) is an aggressive and rare neoplasm of melanocytic origin. To date, few retrospective series and case reports have been reported on MM. This article reviews the current evidence on head and neck MM and the molecular pathways that mediate the pathogenesis of this disease. Head and neck MM accounts for 0.7%-3.8% of all melanomas and involve (in decreasing order of frequency) the sinonasal cavity, oral cavity, pharynx, larynx, and upper esophagus. Although many studies have examined MM of the head and neck and the underlying molecular pathways, individual genetic and molecular alterations were less investigated. Further studies are needed to complement existing data and to increase our understanding of melanocytes tumorigenesis.
- Adhesion Molecules in Primary Oral Mucosal Melanoma: Study of Claudins, Integrins and Immunoglobulins in a Series of 35 Cases(2013) BOLOGNA, Sheyla Batista; NICO, Marcello Menta S.; HSIEH, Ricardo; COUTINHO-CAMILLO, Claudia Malheiros; BUIM, Marcilei E.; FERNANDES, Juliana Dumet; SANGUEZA, Martin; SOARES, Fernando Augusto; LOURENCO, Silvia VanessaPrimary oral mucosal melanoma is a rare aggressive tumor. Recent studies have demonstrated a correlation between increased tumor invasion and the metastatic phenotype and altered adhesion molecule expression profiles. The present study analyzed the expression of integrins, claudins, and immunoglobulin-like adhesion molecules in oral mucosal melanomas and correlated results with clinical parameters. Immunohistochemical analyses of the expression patterns of these molecules were performed on thirty-five cases of primary oral mucosal melanomas organized in a tissue microarray. The results were correlated with clinical and histological features of the cohort. A number of integrin subunits were negative and this was related with vascular invasion. Positivity of integrin beta-3 and CD166 (activated leukocyte cell adhesion molecule) was statistically associated with extensive vascular invasion (P < 0.05). Lower expression of CD54 (intercellular cell adhesion molecule) was associated with cases with extensive necrosis. Most cases with metastatic disease were negative for CD66 (carcinoembryonic antigen-related cell adhesion molecule). Several subunits of claudins were negative and, although not statistically significant, this lack of expression was partially associated with histological factors of poor prognosis. Altered patterns of adhesion molecule expression, mainly integrins and immunoglobulin-like proteins, may participate in the pathogenesis and outcome of oral mucosal melanomas.
conferenceObject Sjogren's syndrome: Histopathological evaluation of thrombosis in specimens of minor salivary glands(2013) BOLOGNA, S.; LOURENO, S. V.; TESHIMA, T. H.; PASOTTO, S.; NICO, M. M. S.- Establishment and Characterization of an Oral Mucosal Melanoma Cell Line (MEMO) Derived From a Longstanding Primary Oral Melanoma(2013) LOURENCO, Silvia V.; BOLOGNA, Sheyla B.; HSIEH, Ricardo; SANGUEZA, Martin; FERNANDES, Juliana D.; NICO, Marcello M. S.Oral mucosal melanoma is rare. Its incidence peaks between 41 and 60 years of age; male/female ratio is 2:1. Preferred oral sites include hard palate and maxillary gingiva. Risk factors have not been clearly identified, but pigmented lesions may be present before the diagnosis of oral melanoma. We report an unusual case of oral mucosal melanoma of long-standing duration on hard palate and maxillary alveolar ridge in a male patient. Histopathologic features confirmed the diagnosis of invasive melanoma with a prominent in situ component. A cell lineage derived from the tumor was established and characterized, with phenotypic markers of melanocytes.